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Experimental study of imiprotrin allergic potency in case of inhalation Cover

Experimental study of imiprotrin allergic potency in case of inhalation

Open Access
|Feb 2020

Abstract

Probable changes were studied in rats’ immune status under experimental conditions with inhalation route of type I pyrethroid–imiprotrin administration, which is the main component of a number of household insecticidal agents. The drug at a concentration of 45.0 mg/m3 interrupts immunological homeostasis in experimental animals. Nonspecific cellular component parameters of immune system have changed significantly. Imiprotrin is capable of inducing delayed hypersensitivity. Imiprotrin induces sensibilization under experimental conditions in more than half of the experimental animals, but the magnitude of the reactions to the intradermal administration of the drug has no probable differences, which allows imiprotin to be attributed to substances with moderate sensibilization potential

DOI: https://doi.org/10.2478/intox-2019-0005 | Journal eISSN: 1337-9569 | Journal ISSN: 1337-6853
Language: English
Page range: 36 - 40
Submitted on: Aug 10, 2018
Accepted on: May 17, 2019
Published on: Feb 20, 2020
Published by: Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2020 Oksana Hrushka, Vira Turkina, Tatiana Alyokhina, Hana Pryzyhley, Borys Kuzminov, published by Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.