Pixantrone, a new anticancer drug with the same old cardiac problems? An in vitro study with differentiated and non-differentiated H9c2 cells

Abbreviations:

DMEM:

Dulbecco´s Modified Eagle medium;

DOX:

Doxorubicin;

EDTA:

Ethylenediamine tetraacetic acid;

EMA:

European Medicines Agency;

FBS:

Fetal bovine serum;

FDA:

Food and Drug Administration;

HBSS:

Hanks’ balanced salt solution;

MTT:

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide;

MTX:

Mitoxantrone;

NHL:

Non-Hodgkin’s lymphoma;

NR:

Neutral Red;

PBS:

Phosphate buffered saline;

PIX:

Pixantrone;

RA:

Retinoic acid;

ROS:

Reactive oxygen species