Have a personal or library account? Click to login
Carvacrol and rosemary oil at higher concentrations induce apoptosis in human hepatoma HepG2 cells Cover

Carvacrol and rosemary oil at higher concentrations induce apoptosis in human hepatoma HepG2 cells

Open Access
|Mar 2015

References

  1. Arunasree KM. (2010). Anti-proliferative eff ects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231. Phytomedicine 17: 581-588.
  2. Burt S. (2004). Essential oils: their antibacterial propertied and potential application in foods. A review. Int J Food Microbiol 94: 223-253.
  3. Carson DA, Ribeiro JM. (1993). Apoptosis and disease. The Lancet 341: 1251-1254.
  4. Dixon RA. (2001). Natural products and plant disease resistance. Nature 411: 843-847.
  5. Foo JB, Yazan LS, Chan KW, Tahir PM, Ismail M. (2013). Kenaf seed oil from supercritical carbon dioxide fl uid extraction induced G1 phase cell cycle arrest and apoptosis in leukemia cells. Afr J Biotech 10: 5389-5397.
  6. Higuchi Y. (2003). Chromosomal DNA fragmentation in apoptosis and necrosis induced by oxidative stress. Bioch Pharm 66: 1527-1535.
  7. Horvathova E, Navarova J, Galova E, Sevcovicova A, Chodakova L, Snahnicanova Z, Melusova M, Kozics K, Slamenova D. (2014). An Assessment of Antioxidative, Chelating and DNA-protective Eff ects of Selected Essential Oil Components of Plants (Eugenol, Carvacrol, Thymol, Borneol, Eucalyptol) and Intact Rosmarinus offi cinalis Oil. J Agric Food Chem 62: 6632-6639.
  8. Horvathova E, Slamenova D, Navarova J. (2010). Administration of rosemary essential oil enhances resistance of rat hepatocytes against DNA-damaging oxidative agents. Food Chem 123: 151-156.
  9. Jantova S, Cipak L, Letasiova S. (2007). Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells. Toxicol In Vitro 21: 25-31.
  10. Ji HF, Li XJ, Zhang HY. (2009). Natural products and drug discovery. EMBO Reports 10: 194-200.
  11. Koehn FE, Carter GT. (2005). The evolving role of natural products in drug discovery. Nat Rev Drug Discovery 4: 206-220.
  12. Kontogianni VG, Tomic G, Nikolic I, Nerantzaki AA, Sayyad N, Stosic-Grujicic S, Stojanovic I, Gerothanassis IP, Tzakos AG. (2013). Phytochemical profi le of Rosmarinus offi cinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. Food Chem 136: 120-129.
  13. Letasiova S, Jantova S, Cipak L, Muckova M. (2006). Berberine - antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells. Cancer Lett 239: 254-262.
  14. Liu Y, Wang W, Fang B, Ma F, Zheng Q, Deng P, Zhao S, Chen M, Yang G, He G. (2013). Anti-tumor eff ect of germacrone on human hepatoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. Eur J Pharmacol 698: 95-102.
  15. Melusova M, Slamenova D, Kozics K, Jantova S, Horvathova E. (2014a). Carvacrol and rosemary essential oil manifest cytotoxic, DNA- protective and pro- apoptotic eff ect having no eff ect on DNA repair. Neoplasma 61: 690-699.10.4149/neo_2014_08425341996
  16. Melusova M, Horvathova E, Jantova S. (2014b). Biologické vlastnosti prírodných látok s protektívnym potenciálom na ľudské bunky kultivované in vitro. In: Interaktívna konferencia Mladých vedcov 2014, 7.5.-6.6.2014 online konferencia, Book of abstracts ISBN: 97880-970712-6-4, in press.
  17. Miller BM, Pujadas E, Gocke E. (1995). Evaluation of the micronucleus test in vitro using Chinese hamster cells: results of four chemicals weakly positive in the in vivo micronucleus test. Envir Mol Mut 26: 240-247.
  18. Mukherjee AK, Basu S, Sarkar N, Ghosh AC. (2001). Advances in cancer therapy with plant based natural products. Curr Med Chem 8: 1467-1486.
  19. Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. (1992). Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1. Proc Natl Acad Sci USA 89: 5408-5412.
  20. Raskovic A, Milanovic I, Pavlovic N, Cebovic T, Vukmirovic S, Mikov M. (2014).\ Antioxidant activity of rosemary (Rosmarinus offi cinalis L.) essential oil and its hepatoprotective potential. BMC Com Alt Med 14: 225.
  21. Rozman T, Jersek B. (2009). Antimicrobial activity of rosemary extracts (Rosmarinus offi cinalis L.) against diff erent species of Listeria. Ac Agr Sol 93: 51-58.
  22. Sivas H, Tomsuk O. (2011). Antiproliferative and apoptotic eff ects of the essential oil of Origanum onites and carvacrol on Hep-G2 cells. Anadolu University of Sciences & Technology-c: Life Sci & Biotech 1: 171-180.
  23. Slamenova D, Horvathova E. (2013a). Cytotoxic, anti-carcinogenic and antioxidant properties of the most frequent plant volatiles. Neoplasma 60: 343-354.10.4149/neo_2013_04623581421
  24. Slamenova D, Horvathova E, Chalupa I, Wsolova L, Navarova J. (2011a). Ex vivo assessment of protective eff ects of carvacrol against DNA lesions induced in primary rat cells by visible light excited methylene blue (VL+MB). Neoplasma 58: 14-19.10.4149/neo_2011_01_1421067261
  25. Slamenova D, Horvathova E, Kovacikova Z, Kozics K, Hunakova L. (2011b). Essential rosemary oil protects testicular cells against DNA-damaging eff ects of H2O2 and DMNQ. Food Chem 129: 64-70.10.1016/j.foodchem.2011.04.020
  26. Slamenová D, Horvathova E, Marsalkova L, Wsolova L. (2008). Carvacrol given to rats in drinking water reduces the level of DNA lesions induced in freshly isolated hepatocytes and testicular cells by H2O2. Neoplasma 55: 394-399.
  27. Slamenova D, Kozics K, Hunakova L, Melusova M, Navarova J, Horvathova E. (2013b). Comparison of biological processes induced in HepG2 cells by tertbutyl hydroperoxide (t-BHP) and hydroperoxide (H2O2): The infl uence of carvacrol. Mutat Res 757: 15-22.10.1016/j.mrgentox.2013.03.01423867853
  28. Valovicova Z, Marvanova S, Meszarosova M, Srancikova A, Trilecova L, Milcova A, Libalova H, Vondracek J, Machala M, Topinka J, Gabelova A. (2009). Diff erences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells. Mutat Res 665: 51-60.
  29. Wu GS, Lu JJ, Guo JJ, Lia YB, Tana W, Danga YY, Zhonga ZF, Xua ZT, Chena XP, Wang YT. (2012). Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia 83: 408-414.
DOI: https://doi.org/10.2478/intox-2014-0027 | Journal eISSN: 1337-9569 | Journal ISSN: 1337-6853
Language: English
Page range: 189 - 194
Submitted on: Sep 22, 2014
Accepted on: Nov 9, 2014
Published on: Mar 4, 2015
Published by: Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2015 Martina Melušová, Soňa Jantová, Eva Horváthová, published by Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.