Long-term (30 days) toxicity of NiO nanoparticles for adult zebrafish Danio rerio

Kovrižnych, Jevgenij A.; Sotníková, Ružena; Zeljenková, Dagmar; Rollerová, Eva; Szabová, Elena

doi:10.2478/intox-2014-0004

Abstract

Nickel oxide in the form of nanoparticles (NiO NPs) is extensively used in different industrial branches. In a test on adult zebrafish, the acute toxicity of NiO NPs was shown to be low, however longlasting contact with this compound can lead to its accumulation in the tissues and to increased toxicity. In this work we determined the 30-day toxicity of NiO NPs using a static test for zebrafish Danio rerio. We found the 30-day LC₅₀ value to be 45.0 mg/L, LC₁₀₀ (minimum concentration causing 100% mortality) was 100.0 mg/L, and LC₀ (maximum concentration causing no mortality) was 6.25 mg/L for adult individuals of zebrafish. Considering a broad use of Ni in the industry, NiO NPs chronic toxicity may have a negative impact on the population of aquatic organisms and on food web dynamics in aquatic systems.

References

Baek YW, An YJ. (2011). Microbial toxicity of metal oxide nanoparticles (CuO, NiO, ZnO, and Sb2O3) to Escherichia coli, Bacillus subtilis, and Streptococcus aureus. Sci Total Environ 409: 1603-1608.
Search in Google Scholar
Dunnick JK, Elwell MR, Radovsky AE, Benson JM, Hahn FF, Nikula KJ, Barr EB, Hobbs CH. (1995). Comparative carcinogenic eff ects of nickel subsulfi de, nickel oxide, or nickel sulfate hexahydrate chronic exposures in the lung. Cancer Res 55: 5251-5256.
Search in Google Scholar
Gong N, Shao K, Feng W, Lin Z, Liang C, Sun Y. (2011). Biotoxicity of nickel oxide nanoparticles and bio-remediation by microalgae Chlorella vulgaris. Chemosphere 83: 510-516.
Search in Google Scholar
Han ZX, Zhang M, Xia Lv C. (2012). Bioaccumulation and toxicity of NiO nanoparticles in Gracilaria lemaneiformis. Advanced Mater Res 518-523: 942-945.
Search in Google Scholar
Hanawa T, Kaga M, Itoh Y, Echizenya T, Oguchi H, Ota M. (1992). Cytotoxicities of oxides, phosphates and sulphides of metals. Biomaterials 13: 20-24.
Search in Google Scholar
Horie M, Nishio K, Fujita K, Kato H, Nakamura A, Kinugasa S, Endoh S, Miyauchi A, Yamamoto K, Murayama H, Niki E, Iwahashi H, Yoshida Y, Nakanishi J. (2009). Ultrafi ne NiO particles induce cytotoxicity in vitro by cellular uptake and subsequent Ni(II) release. Chem Res Toxicol 22: 1415-1426.
Search in Google Scholar
Kovrižnych JA, Sotnikova R, Zeljenkova D, Rollerova E, Szabova E, Wimmerova S. (2013). Acute toxicity of 31 diff erent nanoparticles to zebrafi sh (Danio rerio) tested in adulthood and in early life stages - comparative study. Interdiscip Toxicol 6: 67-73.
Search in Google Scholar
Lichtfi eld JT, Wilcoxon F. (1949). A simplifi ed method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96: 99-113.
Search in Google Scholar
Lin S, Zhao Y, Ji Z, Ear J, Chang CH, Zhang H, Low-Kam C, Yamada K, Meng H, Wang X, Liu R, Pokhrel S, Madler L, Damoiseaux R, Xia T, Godwin HA, Lin S, Nel AE. (2013). Zebrafi sh high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1. Small 9: 1776-1785.
Search in Google Scholar
Lin S, Zhao Y, Xia T, Meng H, Ji Z, Liu R, George S, Xiong S, Wang X, Zhang H, Pokhrel S, Madler L, Damoiseaux R, Lin S, Nel AE. (2011). High content screening in zebrafi sh speeds up hazard ranking of transition metal oxide nanoparticles. ACS Nano 5: 7284-7295.
Search in Google Scholar
Oberdorster E, McClellan-Green P, Haasch M. (2006). Ecotoxicity of engineered nanomaterials. In Nanomaterials Toxicity, Health and Enviromental Issues (Challa S. S. R. Kumar Wiley, Editors), 333 pp.
Search in Google Scholar
OECD 203. (1992). Fish, Acute Toxicity Testing of Chemicals. OECD 203,17.7.1992, 9 pp.
Search in Google Scholar
Ogami A, Morimoto Y, Myojo T, Oyabu T, Murakami M, Todoroki M, Nishi K, Kadoya C, Yamamoto M, Tanaka I. (2009). Pathological features of diff erent sizes of nickel oxide following intratracheal instillation in rats. Inhal Toxicol 21: 812-818.
Search in Google Scholar
ON 46 6807. (1988). Test of acute toxicity on the fi sh and other aquatic animals. 31 pp.
Search in Google Scholar
Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt R, Kane AB. (2011). Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci 124: 138-148.
Search in Google Scholar
Rao KV, Sunandana CS. (2008). Eff ect of fuel to oxidizer ratio on the structure, micro structure and EPR of combustion synthesized NiO nanoparticles. J Nanosci Nanotechnol 8: 4247-4253.
Search in Google Scholar
Salimi A, Sharifi E, Noorbakhsh A and Soltanian S. (2007). Direct electrochemistry and electrocatalytic activity of catalase immobilized onto electrodeposited nano-scale islands of nickel oxide. Biophys Chem 125: 540-548.
Search in Google Scholar
Schrand AM, Rahman MF, Hussain SM, Schlager JJ, Smith DA, Syed AF. (2010). Metal-based nanoparticles and their toxicity assessment. Wiley Interdisciplinary Reviews. Nanomed Nanobiotech 2: 544-568.
Search in Google Scholar
Straif K, Benbrahim-Tallaa L, Baan R, Grosse Y, Scretan B, El Ghissassi F, Bouvard V, Guha N, Freeman C, Galichet L, Cogliano V. (2009). A review of human carcinogens -Part C: metals, arsenic, dusts, and fi bres. Lancet Oncol 10: 453-454.
Search in Google Scholar
US Research Nanomaterials, Inc. Material Safety Data Sheet, http://s.b5z.net/i/u/10091461/f/MSDS-NANOPOWDERS/US3355.pdf
Search in Google Scholar
Wiesner MR, Lowry GV, Alvarez P, Dionysiou D, Biswas P. (2006). Assessing the risks of manufactured nanomaterials. Environ Sci Technol 40: 4336-4345.
Search in Google Scholar
Wu C. (2012). Physiochemical Characteristics Contributing to the Cytotoxicity of Transition Metal Oxides. Master‘s Thesis, Applied and Environmental Biology, Missouri University of Science and Technology: 77 pp.
Search in Google Scholar

Long-term (30 days) toxicity of NiO nanoparticles for adult zebrafish Danio rerio

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