Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6)

Miroslav Pohanka; Jakub Sobotka; Hana Svobodova; Rudolf Stetina

doi:10.2478/intox-2013-0029

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Sulfur mustard induced oxidative stress and its alteration using asoxime (HI-6)

Interdisciplinary Toxicology

Volume 6 (2013): Issue 4 (December 2013)

By: Miroslav Pohanka, Jakub Sobotka, Hana Svobodova and Rudolf Stetina

Open Access

|Mar 2014

Abstract

Sulfur mustard (SM) is a blister agent with cytotoxic mechanism of action. There is no suitable treatment based on administration of an antidote. In this study, Wistar rats were exposed to SM in doses of 0-40 mg/kg body weight and treated with the compound HI-6. The treatment provided no significant effect on ferric reducing antioxidant power of blood and plasma. However, HI-6 caused an increase in the level of thiobarbituric acid reactive substances. This stressogenic response was presumably the cause of the significant elevation of the blood level of both glutathione reductase and reduced glutathione. HI-6 appears to be suitable for enhancing prophylactically oxidative stress protection from small oxidative insult

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Articles in this issue

DOI: https://doi.org/10.2478/intox-2013-0029 | Journal eISSN: 1337-9569 | Journal ISSN: 1337-6853

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Language: English

Page range: 198 - 202

Published on: Mar 11, 2014

Published by: Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

blister agent,

acetylcholinesterase,

oxidative insult,

reactive oxygen species,

cholinergic anti-inflammatory pathway

Related subjects:

Medicine,

Clinical medicine,

Pharmacology, toxicology

© 2014 Miroslav Pohanka, Jakub Sobotka, Hana Svobodova, Rudolf Stetina, published by Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
This work is licensed under the Creative Commons License.

Volume 6 (2013): Issue 4 (December 2013)