Effects of cadmium chloride on mouse inner medullary collecting duct cells

Park, Eun-Kee; Mak, Sally K.; Hammock, Bruce D.

doi:10.2478/intox-2013-0025

Abstract

Cadmium is a known renal toxin. The cytotoxic effect of cadmium chloride (CdCl₂) was evaluated on renal inner medullary collecting duct cells (mIMCD3). The 24 hr LC₅₀ value for CdCl₂ in mIMCD3 cells was 40 μM. The present study showed that mIMCD3 cells were sensitive to CdCl₂ exposure

References

Burg MB. (2002). Response of renal inner medullary epithelial cells to osmotic stress. Comp Biochem Physiol A Mol Integr Physiol 133: 661-666.
Search in Google Scholar
Cai Q, Dmitrieva NI, Michea LF, Rocha G, Ferguson D and Burg MB. (2003). Toxicity of acetaminophen, salicylic acid, and caff eine for fi rst-passage rat renal inner medullary collecting duct cells. J Pharmacol Exp Ther 306: 35-42.
Search in Google Scholar
Ferraro PM, Costanzi S, Naticchia A, Sturniolo A and Gambaro G. (2010). Low level exposure to cadmium increases the risk of chronic kidney disease: analysis of the NHANES 1999-2006. BMC Public Health 10: 304.
Search in Google Scholar
Gena P, Calamita G and Guggino WB. (2010). Cadmium impairs albumin reabsorption by down-regulating megalin and CIC5 channels in renal proximal tubule cells. Environ Health Perspect 118: 1551-1556.
Search in Google Scholar
Gennari A, Cortese E, Boveri M, Casado J and Prieto P. (2003). Sensitive endpoints for evaluating cadmium-induced acute toxicity in LLC-PK1 cells. Toxicol 183: 211-220.
Search in Google Scholar
Järup L. (2002). Cadmium overload and toxicity. Nephrol Dial Transplant 17(Suppl2): 35-39.
Search in Google Scholar
Järup L, Berglund M, Elinder CG, Nordberg G and Vahter M. (1998). Health effects of cadmium exposure - a review of the literature and a risk estimate.Scand J Work, Environ Health 24(Suppl 1): 1-51.
Search in Google Scholar
Kinne-Saff ran E, Hülseweh M, Pfaff C and Kinne RK. (1993). Inhibition of Na,KATPase by cadmium: diff erent mechanisms in diff erent species. Toxicol Appl Pharmacol 121: 22-29.
Search in Google Scholar
Kobayashi E, Suwazono Y, Dochi M, Honda R and Kido T. (2009). Infl uence of consumption of cadmium-polluted rice or Jinzu river water on occurrence of renal tubular dysfunction and/or itai-itai disease. Bio Trace Elem Res 127: 257-268.
Search in Google Scholar
Kojima N, Saito H, Nishikawa M, Yuri S, Jo OD, Pham PC, Yanagawa N and Yanagawa N. (2011). Lithium induces c-Ret expression in mouse inner medullary collecting duct cells. Cell Signal 23: 371-379.
Search in Google Scholar
Mao WP, Ye JL, Guan ZB, Zhau JM, Zhang C, Zhang NN, Jiang P and Tian T. (2007). Cadmium induces apoptosis in human embryonic kidney (HEK) 293 cells by caspase-dependent and -independent pathways acting on mitochondria.Toxicol In Vitro 21: 343-354.
Search in Google Scholar
Mao WP, Zhang NN, Zhou FY, Li WX, Liu HY, Feng J, Zhou L, Wei CJ, Pan YB and He ZJ. (2011). Cadmium directly induced mitochondrial dysfunction of human embryonic kidney cells. Hum Exp Toxicol 30: 920-929.
Search in Google Scholar
Park EK, Mak SK, Kultz D and Hammock BD. (2007). Evaluation of cytotoxicity attributed to thimerosal on murine and human kidney cells. J Toxicol Environ Health A 70: 2092-2095.
Search in Google Scholar
Park EK, Mak SK, Kultz D and Hammock BD. (2008). Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines. J Environ Sci Health B 43: 71-74.
Search in Google Scholar
Prozialeck WC, Wellington DR and Lamar PC. (1993). Comparison of the cytotoxicity eff ects of cadmium chloride and cadmium-metallothionein in LLCPK1 cells. Life Sci 53: 337-342.
Search in Google Scholar
Rocha GM, Michea LF, Peters EM, Kirby M, Xu Y, Ferguson DR and Burg MB. (2001). Direct toxicity of nonsteroidal antiinfl ammatory drugs for renal medullary cells. Proc Natl Acad Sci USA 98: 5317-5322.
Search in Google Scholar
Schenk LK, Rinschen MM, Klokkers J, Kurian SM, Neugebauer U, Salomon DR, Pavenstaedt H, Schlatter E and Edemir B. (2010). Cyclosporin-A induced toxicity in rat renal collecting duct cells: interference with enhanced hypertonicity induced apoptosis. Cell Physiol Biochem 26: 887-900.
Search in Google Scholar
Thomas LD, Hodgson S, Nieuwenhuijsen M and Jarup L. (2009). Early kidney damage in a population exposed to cadmium and other heavy metals. Environ Health Perspect 117: 181-184.
Search in Google Scholar
Van Vleet TR and Schnellmann RG. (2003). Toxic nephropathy: environmental chemicals. Semin Nephrol 23: 500-508.
Search in Google Scholar
Valverde M, Trejo C and Rojas E. (2001). Is the capacity of lead acetate and cadmium chloride to induce genotoxic damage due to direct DNA-metal interaction? Mutagenesis 16: 265-270.10.1093/mutage/16.3.26511320153
Search in Google Scholar
Yancey PH, Clarl ME, Hand SC, Bowlus RD and Somero GN. (1982). Living with water stress: Evolution of osmolyte systems. Science 217: 1214-1222.
Search in Google Scholar

Effects of cadmium chloride on mouse inner medullary collecting duct cells

Abstract

Paradigm

My account