Have a personal or library account? Click to login
Lycopene supplementation prevents reactive oxygen species mediated apoptosis in Sertoli cells of adult albino rats exposed to polychlorinated biphenyls Cover

Lycopene supplementation prevents reactive oxygen species mediated apoptosis in Sertoli cells of adult albino rats exposed to polychlorinated biphenyls

Interdisciplinary Toxicology
Volume 6 (2013): Issue 2 (June 2013)
By: Gunasekaran Krishnamoorthy,  Kandaswamy Selvakumar,  Prabhu Venkataraman,  Perumal Elumalai and  Jagadeesan Arunakaran  
Open Access
|Aug 2013

References

  1. Anway MD, Folmer J, Wright WW, Zirkin BR. (2003). Isolation of Sertoli cells from adult rat testes: an approach to ex vivo studies of Sertoli cell function. Biol Reprod. 68: 996-1002.
    Search in Google Scholar
  2. Atessahin A, Karahan I, Turk G, Gur S, Yılmaz S, Ceribas AO. (2006a). Protective role of lycopene on cisplatin induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reprod Toxicol 21: 42-47.10.1016/j.reprotox.2005.05.003
    Search in Google Scholar
  3. Atessahin A, Turk G, Karahan I, Yilmaz S, Ceribasi AO, Bulmus O. (2006b). Lycopene prevents adriamycin-induced testicular toxicity in rats. Fertil Steril85: 1216-1222.10.1016/j.fertnstert.2005.11.035
    Search in Google Scholar
  4. Bhuvaneswari V and Nagini S. (2005.) Lycopene: a review of its potential as an anticancer agent. Curr. Med. Chem. Anticancer Agents 5: 627-635.10.2174/156801105774574667
    Search in Google Scholar
  5. Carreau S, Foucault P, Drosdowsky MA. (1994). Sertoli cells: Functional aspects compared in rats, pigs and man. Ann Endocrinol 55: 203-220.
    Search in Google Scholar
  6. Chinnaiyan AM, O’Rourke K, Tewari M, Dixit VM. (1995). FADD, a novel deathdomain- containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505-512.
    Search in Google Scholar
  7. Cohen LA. (2002). A review of animal model studies of tomato carotenoids, lycopene and cancer chemoprevention. Exp Biol Med 227: 864-868.
    Search in Google Scholar
  8. de Winther MP, Kanters E, Kraal G, Hofker MH. (2005). Nuclear factor kappaB signaling in atherogenesis. Arterioscler Thromb Vasc Biol 25: 904-914.
    Search in Google Scholar
  9. De Castro BR, Korrick SA, Spengler JD, Soto AM. (2006). Estrogenic activity of polychlorinated biphenyls present in human tissue and the environment. Environ Sci Technol 40: 2819-2825.
    Search in Google Scholar
  10. Devasagayam TP and Tarachand U. (1987). Decreased lipid peroxidation in rat kidneys during gestation. Biochem Biophys Res Comm 145: 134-138.
    Search in Google Scholar
  11. Dubois W, Callard GV. (1990). Shark testis model: stage-dependent functions and the regulation of spermatogenesis. J Exp Zool 4: 142-144.
    Search in Google Scholar
  12. Eldadah BA, Faden AI. (2000). Caspase pathways, neuronal apoptosis and CNS injury. J Neurotrauma 17: 811-829.
    Search in Google Scholar
  13. Elumalai P, Krishnamoorthy G, Selvakumar K, Arunkumar R, Venkataraman P, Arunakaran J. (2009). Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats. Reprod Toxicol 27: 41-45.
    Search in Google Scholar
  14. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. (1998). A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1: 43-50.
    Search in Google Scholar
  15. Green DR, Reed JC. (1998). Mitochondria and apoptosis. Science 281: 1309-1312.
    Search in Google Scholar
  16. Griffith HR, Unswoth J, Blake DR, Lunec J. (1988). Oxidation of amino acidswithin serum proteins. In: Rice-Evans (Ed.), Free radicals: Chemistry, Pathology and Medicine Richeliue, London, pp.439-454.
    Search in Google Scholar
  17. Hengartner MO. (1999). Programmed cell death in the nematode C. elegans. Recent Prog Horm Res 54: 213-222.
    Search in Google Scholar
  18. Griswold MD. (1993). The central role of Sertoli cells in spermatogenesis. Seminarsin Cell & Develop Biol 9: 411-416.
    Search in Google Scholar
  19. Hochstein P, Ernster L. (1963.) ADP-activated lipid peroxidation coupled on TPNH oxidase system of microsomes. Biochem Biophys Res Comm 12: 388-394.10.1016/0006-291X(63)90111-6
    Search in Google Scholar
  20. Kasai H, Crain PF, Kuchino, Y, Nishimura S, Ootsyama A, Tanoaka H. (1986). Formation of 8-hydroxy-guanine moiety in cellular DNA by agents producing oxygen radical and evidence for its repair. Carcinogenesis 7: 1849-1851.
    Search in Google Scholar
  21. Khan SM, Oliver RH, Dauffenbach LM, Yeh J. (2000). Depletion of Raf-1 protooncogene by geldanamycin causes apoptosis in human luteinized granulosa cells. Fertil Steril 74: 359-365.
    Search in Google Scholar
  22. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT. (1997). Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278: 294-298.
    Search in Google Scholar
  23. Krishnamoorthy G, Venkataraman P, Arunkumar A, Vignesh RC, Aruldhas MM, Arunakaran J. (2007). Ameliorative effect of vitamins (alpha-tocopherol and ascorbic acid) on PCB (Aroclor 1254) induced oxidative stress in rat epididymal sperm. Reprod Toxicol 23: 239-245.
    Search in Google Scholar
  24. Krishnamoorthy G, Selvakumar K, Elumalai P, Venkataraman P, Arunakaran J. (2011). Protective role of lycopene on polychlorinated biphenyls (Aroclor 1254)-induced adult rat Sertoli cell dysfunction by increased oxidative stress and endocrine disruption. Biomed Prev Nutr 1: 116-125.
    Search in Google Scholar
  25. Krishnamoorthy G, Murugesan P, Muthuvel R, Gunadharini DN, Vijayababu MR, Arunkumar A, Venkataraman P, Aruldhas MM, Arunakaran J. (2005). Effect of Aroclor 1254 on Sertoli cellular antioxidant system, androgen binding protein and lactate in adult rat in vitro. Toxicology 212: 195-205.
    Search in Google Scholar
  26. Martin SJ, O’Brien GA, Nishioka WK, McGahon AJ, Mahboubi A, Saido TC, Green DR. (1995). Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J Biol Chem 270: 6425-6428.
    Search in Google Scholar
  27. McLean MR., Bauer U, Amaro AR, Robertson LW. (1996). Identification of catechol and hydroquinone metabolites of 4-monochlorobiphenyl. Chem ResToxicol 9: 158-164.
    Search in Google Scholar
  28. Murugesan P, Balaganesh M, Balasubramanian K, Arunakaran J. (2007a). Effects of polychlorinated biphenyl (Aroclor 1254) on steroidogenesis and antioxidant system in cultured adult rat Leydig cells. J Endocrinol 192: 325-338.10.1677/joe.1.0687417283232
    Search in Google Scholar
  29. Murugesan P, Senthilkumar J, Balasubramanian K, Aruldhas MM, Arunakaran J. (2005a). Impact of polychlorinated biphenyl Aroclor 1254 on testicular antioxidant system in adult rats. Hum Exp Toxicol 24: 61-66.10.1191/0960327105ht500oa15850280
    Search in Google Scholar
  30. Murugesan P, Muthusamy T, Balasubramanian K, Arunakaran J. (2005b). Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)-induced oxidative damage in Leydig cells. Free Rad Res39: 1259-1272.10.1080/1071576050030815416298753
    Search in Google Scholar
  31. Nehar D, Mauduit C, Boussouar F, Benahmed M. (1998). Interleukin 1a Stimulates Lactate Dehydrogenase A Expression and Lactate production in cultured porcine Sertoli cells. Biol Reprod 59: 1425-1432.
    Search in Google Scholar
  32. Orrenius S, McCabe MJ Jr, Nicotera P. (1992). Ca(2+)-dependent mechanisms of cytotoxicity and programmed cell death. Toxicol Lett 64-65 Spec No: 357-64.
    Search in Google Scholar
  33. Orth JM, Gunsalus GL, Lamperti AA. (1988). Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development. Endocrinology122: 787-794.
    Search in Google Scholar
  34. Pick E, Keisari Y. (1981). Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages-induction by multiple nonphagocytic stimuli. Cell Immunol 59: 301-318.
    Search in Google Scholar
  35. Porrini M, Riso P. (2000). Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption. J Nutr 130: 189-192.
    Search in Google Scholar
  36. Puntarulo S, Cederbaum AI. (1988). Effect of oxygen concentration on microsomal oxidation of ethanol and generation of oxygen radicals. Biochem J251: 787-794.
    Search in Google Scholar
  37. Rao AV, Agarwal S. (2000). Role of antioxidant lycopene in cancer and heart disease. J Am Coll Nutr 19: 563-569.
    Search in Google Scholar
  38. Ratnasoorya WD. (1984). Effect of atropine on fertility of female rat and sperm motility. Indian J Exp Biol 22: 463-470.
    Search in Google Scholar
  39. Rudel T, Bokoch GM. (1997). Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 6: 1571-1574.
    Search in Google Scholar
  40. Schlezinger JJ, Keller J, Verbrugge LA, Stegeman JJ. (2000). 3,3’,4,4’-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production. Comp. Biochem. Physiol C Toxicol Pharmacol 125: 273-286.
    Search in Google Scholar
  41. Seligman J, Shalgi K, Oschry Y, Kosower NS. (1991). Sperm analysis by flow cytometry using the fluorescent thiol labeling agent monobromobimane. Mol Reprod Dev 29: 276-281.
    Search in Google Scholar
  42. Senthilkumar J, Banudevi S, Sharmila M, Murugesan P, Srinivasan N, Balasubramanian K, Aruldhas MM, Arunakaran J. (2004). Effects of vitamin C and E on PCB (Aroclor 1254) induced oxidative stress, androgen binding protein and lactate in rat Sertoli cells. Reprod Toxicol 9: 201-208.
    Search in Google Scholar
  43. Shi Y, Song Y, Wang Y, Wang Y, Liang Y, Hu Y, Yu H, Guan X, Cheng J, Yang K. (2009). β-Benzene hexachloride induces apoptosis of rat Sertoli cells through generation of reactive oxygen species and activation of JNKs and FasL. Environ Toxicol 26: 124-135.
    Search in Google Scholar
  44. Shimizu K, Ogawa F, Thiele JJ, Bae S, Sato S. (2007). Lipid peroxidation is enhanced in Yusho victims 35 years after accidental poisoning with polychlorinated biphenyls in Nagasaki, Japan. J Appl Toxicol 27: 195-197.
    Search in Google Scholar
  45. Scolastici C, Lopes GA, Barbisan LF, Salvadori DM. (2008). Tomato oleoresin inhibits DNA damage but not diethylnitrosamine-induced rat hepatocarcinogenesis. Exp Toxicol Pathol 60: 59-68.
    Search in Google Scholar
  46. Scolastici C, Alves de Lima RO, Barbisan LF, Ferreira AL, Ribeiro DA, Salvadori DM. (2008). Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and micronucleus test. Toxicol In vitro22: 510-514.
    Search in Google Scholar
  47. Song Y, Yang KD. (2006). Effect of p, p’-DDE on DNA damage and expression of FasL gene of rat Sertoli cell in vitro. Wei Sheng Yan Jiu 35: 261-263.
    Search in Google Scholar
  48. Steinberger A , Klinefelter GR. (1993). Sensitivity of Sertoli and Leydig cells to xenobiotics in in vitro models. Reprod Toxicol 7: 23-57.
    Search in Google Scholar
  49. Steinberger A, Steinberger E. (1971). Replication pattern of Sertoli cells in maturing rat testis in vivo and in organ culture. Biol Reprod 4: 84-87.
    Search in Google Scholar
  50. Syed V, Gu W, Hecht N. (1997). Sertoli cells in culture and mRNA differential display provide a sensitive early warning assay system to detect changes induced by xenobiotics. J Androl 18: 264-273.
    Search in Google Scholar
  51. Tang L, Guan H, Ding X, Jia-Sheng W. (2007). Modulation of aflatoxin toxicity and biomarkers by lycopene in F344 rats. Toxicol Appl Pharmacol 219: 10-17.
    Search in Google Scholar
  52. Tapiero H, Townsend DM, Tew KD. (2004). The role of carotenoids in the prevention of human pathologies. Biomed Pharmacother 58: 100-110.
    Search in Google Scholar
  53. Turk G, Atessahin A, Sonmez M, Yuce A, Ceribas AO. (2007). Lycopene protects against cyclosporine A-induced testicular toxicity in rats. Theriogenology67: 778-785.
    Search in Google Scholar
  54. Twaroski TP, O’Brien ML, Larmonier N, Glauert HP, Rorbertson LW. (2001). Polychlorinated biphenyls-induced effects of metabolic enzymes, AP-1 binding, vitamin E, and oxidative stress in the rat liver. Toxicol Appl Pharmacol171: 85-93.
    Search in Google Scholar
  55. Venkataraman P, Selvakumar K, Krishnamoorthy G, Muthusami S, Rameshkumar R, Prakash S, Arunakaran J. (2010). Effect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats. Neurosci Res 66: 189-197.
    Search in Google Scholar
  56. Venkataraman P, Krishnamoorthy G, Vengatesh G, Srinivasan N, Aruldhas MM, Arunakaran J. (2008). Protective role of melatonin on PCB (Aroclor 1,254) induced oxidative stress and changes in acetylcholine esterase and membrane bound ATPases in cerebellum, cerebral cortex and hippocampus of adult rat brain. Int J Dev Neurosci 26: 585-591.
    Search in Google Scholar
  57. Wang X. (2001). The expanding role of mitochondria in apoptosis. Genes Dev15: 2922-2933.
    Search in Google Scholar
  58. Yagi M, Suzuki K, Suzuki H. (2006). Apoptotic Sertoli cell death in hypogonadic (hgn/hgn) rat testes during early postnatal development. Asian J Androl8: 535-541.
    Search in Google Scholar
  59. Yilmaz S, Atessahin A, Sahna E, Karahan I, Ozer S. (2006). Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity. Toxicology218: 164-171.
    Search in Google Scholar
DOI: https://doi.org/10.2478/intox-2013-0015 | Journal eISSN: 1337-9569 | Journal ISSN: 1337-6853
Journal RSS Feed
Language: English
Page range: 83 - 92
Published on: Aug 24, 2013
Published by: Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
apoptosis,
oxidative stress,
caspases,
lycopene,
polychlorinated biphenyls,
Sertoli cells
Related subjects:
Medicine,
Clinical medicine,
Pharmacology, toxicology

© 2013 Gunasekaran Krishnamoorthy, Kandaswamy Selvakumar, Prabhu Venkataraman, Perumal Elumalai, Jagadeesan Arunakaran, published by Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
This work is licensed under the Creative Commons License.

Previous articleVolume 6 (2013): Issue 2 (June 2013)Next article