Solid Pseudopapillary Neoplasm of the Pancreas -Raising Awareness of a Rare Tumor

Andreea Ioana Neagu; Ana Daniela Pascariu; Josephine Raad; Andrei Valentin Neagu; Alexandru Băjenaru; Adelina Lucreţia Birceanu-Corobea; Cezar Iulian Beţianu

doi:10.2478/inmed-2021-0183

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Solid Pseudopapillary Neoplasm of the Pancreas -Raising Awareness of a Rare Tumor

Internal Medicine

Volume 18 (2021): Issue 5 (October 2021)

By: Andreea Ioana Neagu, Ana Daniela Pascariu, Josephine Raad, Andrei Valentin Neagu, Alexandru Băjenaru, Adelina Lucreţia Birceanu-Corobea and Cezar Iulian Beţianu

Open Access

|Nov 2021

Abstract

Solid pseudopapillary neoplasm (SPN) is a rare clinical entity. One third of the patients are asymptomatic and the diagnostic is based on imaging studies (abdominal ultrasound, computed tomography, magnetic resonance imaging) and histological examination of biopsies obtained most frequently by endoscopic ultrasound-guided fine-needle aspiration. In this article we made a short review of the literature and present the imaging and histological aspects found in our patients with SNP.

References

1. Peyman Dinarvand, Jinping Lai. Solid Pseudopapillary Neoplasm of the Pancreas: A Rare Entity With Unique Features. Archives of Pathology & Laboratory Medicine 2017;141(7):990-995.10.5858/arpa.2016-0322-RS28661210
Search in Google Scholar Back to article
2. Zaher I. Chakhachiro, Ghazi Zaatari. Solid-Pseudopapillary Neoplasm: A Pancreatic Enigma. Archives of Pathology & Laboratory Medicine 2009;133 (12):1989-1993.10.5858/133.12.198919961258
Search in Google Scholar Back to article
3. Yu PF, Hu ZH, Wang XB, et al. Solid pseudopapillary tumor of the pancreas: a review of 553 cases in Chinese literature. World journal of gastroenterology 2010;16(10):12091214.
Search in Google Scholar Back to article
4. Shi S, Zhou Y, Hu C. Clinical manifestations and multi-slice computed tomography characteristics of solid pseudopapillary neoplasms of the pancreas between males and females. BMC medical imaging 2019, 19(1), 87.10.1186/s12880-019-0390-9685290731718581
Search in Google Scholar Back to article
5. Yagcý A, Yakan S, Coskun A, et al. Diagnosis and treatment of solid pseudopapillary tumor of the pancreas: experience of one single institution from Turkey. World journal of surgical oncology 2013;11:308.10.1186/1477-7819-11-308422077924289652
Search in Google Scholar Back to article
6. Rajtar KZ, Sznajder K, Milto KM. Diagnostic imaging of a solid pseudopapillary tumour of the pancreas in a 20-year-old woman - a case study. Przeglad gastroenterologiczny 2016;11(3):214217.10.5114/pg.2016.57882504796827713786
Search in Google Scholar Back to article
7. Rai S, Prabhu S, Rai S, et al. Image Findings of Solid Pseudopapillary Neoplasms of the Pancreas on Multiphasic Multidetector CT Scan-A Single Institute Experience from Southern India. Journal of clinical and diagnostic research 2017;11(9):TC01TC05.10.7860/JCDR/2017/24190.10530571382429207802
Search in Google Scholar Back to article
8. Lee JH, Yu JS, Kim H, et al. Solid pseudopapillary carcinoma of the pancreas: differentiation from benign solid pseudopapillary tumour using CT and MRI. Clin Radiol 2008;63:10061014.10.1016/j.crad.2008.04.00718718230
Search in Google Scholar Back to article
9. Wang DB, Wang QB, Chai WM, et al. Imaging features of solid pseudopapillary tumor of the pancreas on multi-detector row computed tomography. World Journal of Gastroenterology 2009;15(7):829835.10.3748/wjg.15.829265338219230043
Search in Google Scholar Back to article
10. Cantisani V, Mortele KJ, Levy A, et al. MR Imaging Features of Solid Pseudopapillary Tumor of the Pancreas in Adult and Pediatric Patients. American Journal of Roentgenology 2003;181(2)395-401.10.2214/ajr.181.2.181039512876017
Search in Google Scholar Back to article
11. Klimstra DS, Wenig BM, Heffess CS. Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential. Semin Diagn Pathol 2000; 17(1): 6680.
Search in Google Scholar Back to article
12. Meriden Z, Shi C, Edil BH, et al. Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Am J Surg Pathol 2011;35(7): 81988.10.1097/PAS.0b013e31821a9a14328316321677537
Search in Google Scholar Back to article
13. La Rosa S, Bongiovanni M. Pancreatic Solid Pseudopapillary Neoplasm: Key Pathologic and Genetic Features. Archives of Pathology & Laboratory Medicine 2020; In-Press.10.5858/arpa.2019-0473-RA
Search in Google Scholar Back to article
14. Kim MS, Sun CD, Park KC, et al. Accumulation of beta-catenin protein, mutations in exon-3 of the beta-catenin gene and a loss of heterozygosity of 5q22 in solid pseudopapillary tumor of the pancreas. J Surg Oncol 2006;94(5):418425.
Search in Google Scholar Back to article
15. Terris B, Cavard C. Diagnosis and molecular aspects of solid-pseudopapillary neoplasms of the pancreas. Semin Diagn Pathol 2014;31(6):484490.10.1053/j.semdp.2014.08.010
Search in Google Scholar Back to article
16. Ohara Y, Oda T, Hashimoto S, et al. Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: key immunohistochemical profiles for differential diagnosis (Observational study). World J Gastroenterol 2016; 22(38): 85968604.10.3748/wjg.v22.i38.8596
Search in Google Scholar Back to article
17. Basturk O, Coban I, Adsay NV. Pancreatic cysts: Pathologic classification, differential diagnosis, and clinical implications. Arch Pathol Lab Med. 2009;133:423-38.10.5858/133.3.423
Search in Google Scholar Back to article
18. Chung EM, Travis MD, Conran RM. Pancreatic tumors in children: radiologic-pathologic correlation. RadioGraphics 2006; 26(4): 12111238.10.1148/rg.264065012
Search in Google Scholar Back to article
19. Hackeng WM, Hruban RH, Offerhaus GJA, et al. Surgical and molecular pathology of pancreatic neoplasms. Diagn Pathol 2016; 11(1): 47.10.1186/s13000-016-0497-z
Search in Google Scholar Back to article
20. Klimstra DS, Wenig BM, Adair CF, et al. Pancreatoblastoma: a clinicopathologic study and review of the literature. Am J Surg Pathol 1995; 19(12): 13711389.10.1097/00000478-199512000-00005
Search in Google Scholar Back to article
21. Romics L Jr., et al. Solid pseudopapillary neoplasm of the pancreasproposed algorithms for diagnosis and surgical treatment. Langenbecks Arch Surg 2010;395:747755
Search in Google Scholar Back to article
22. Vollmer CM Jr, Dixon E, Grant DR. Management of a solid pseudopapillary tumor of the pancreas with liver metastases. HPB 2003;5:264267.
Search in Google Scholar Back to article
23. Maffuz A, FdeT B, Silva JA, et al. Preoperative gemcitabine for unresectable, solid pseudopapillary tumour of the pancreas. Lancet Oncology 2005;6:185186.10.1016/S1470-2045(05)01770-5
Search in Google Scholar Back to article
24. Strauss JF, Hirsch VJ, Rubey CN, et al. Resection of a solid and papillary epithelial neoplasm of the pancreas following treatment with cis-platinum and 5-fluorouracil: a case report. Med Pediatr Oncol 1993;21:365367.10.1002/mpo.2950210511
Search in Google Scholar Back to article
25. Fried P, Cooper J, Balthazar E, et al. A role for radiotherapy in the treatment of solid and papillary neoplasms of the pancreas. Cancer 1985;56:27832785.10.1002/1097-0142(19851215)56:12<2783::AID-CNCR2820561211>3.0.CO;2-Q
Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.2478/inmed-2021-0183 | Journal eISSN: 1220-5818 | Journal ISSN: 1220-5818

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Language: English

Page range: 63 - 71

Published on: Nov 15, 2021

Published by: Romanian Society of Internal Medicine

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

solid pseudopapillary neoplasm,

Related subjects:

Internal medicine, other,

Cardiology,

Gastroenterology,

Pneumology

© 2021 Andreea Ioana Neagu, Ana Daniela Pascariu, Josephine Raad, Andrei Valentin Neagu, Alexandru Băjenaru, Adelina Lucreţia Birceanu-Corobea, Cezar Iulian Beţianu, published by Romanian Society of Internal Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 18 (2021): Issue 5 (October 2021)