Abstract
We are presenting a case of a 38-year -old man was admitted to the hospital with biliary obstruction and Clostridium Difficile infection. The hepatic biochemical profile improved during corticosteroid therapy, which is a change more characteristic of autoimmune hepatitis than of primary sclerosing cholangitis, needs for a positive diagnostic an endoscopic retrograde cholangiopancreatography and a biopsy of gastric and duodenum mucosae. The abnormalities in the results of liver-function tests due to primary sclerosing cholangitis may have been resulted in part to the intestinal inflammation due to Crohn disease; the abnormalities improved with therapy directed at suppressing that inflammation.