Is Chronic Kidney Disease Reversible?

Sergiu Dumitrache; Mircea Penescu

doi:10.2478/inmed-2019-0060

Abstract

Chronic kidney disease, no matter the aetiology, has a progressive evolution and a negative prognosis. The rapidity of nephrons loss and deterioration of renal function depends on the aetiology of the kidney disease, the prompt diagnosis, efficiency of the treatment and the patient compliance to the treatment, diet and suitable lifestyle. The therapeutic control of the mechanisms of progression have also demonstrated that it could be possible to attenuate or even to stop the evolution towards kidney failure.

References

1.Olson JL, Heptinstall RH (1988) Nonimmunologic mechanisms of glomerular injury. Lab Invest 59:564578
Search in Google Scholar Back to article
2.Morrison AB, Howard RM (1966) The functional capacity of hypertrophied nephrons: effect of partial nephrectomy on the clearance of inulin and PAH in the rat. J Exp Med 123:829844 5.10.1084/jem.123.5.829
Search in Google Scholar Back to article
3.Shimamura T, Morrison AB (1975). A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats. Am J Pathol 79:95106
Search in Google Scholar Back to article
4.Brenner BM, Meyer TW, Hostetter TH (1982) Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med 307:65265910.1056/NEJM198209093071104
Search in Google Scholar Back to article
5.Nath KA, Kren SM, Hostetter TH (1986) Dietary protein restriction in established renal injury in the rat. Selective role of glomerular capillary pressure in progressive glomerular dysfunction. J Clin Invest 78:11991205377179210.1172/JCI1127034238053771792
Search in Google Scholar Back to article
6.Diamond JR, Karnovsky MJ; (1988) Focal and segmental glomeruloscierosis: Analogies to atherosclerosis; Kidney Int, 33. 9/792410.1038/ki.1988.87
Search in Google Scholar Back to article
7.Fogo AB (2000) Glomerular hypertension, abnormal glomerular growth, and progression of renal diseases. Kidney Int Suppl 75: S152110.1046/j.1523-1755.57.s75.5.x
Open DOI Search in Google Scholar Back to article
8.Klahr S, (1990) Progression of chronic renal disease; Nutrition., 6(3):207-212.2135999
Search in Google Scholar Back to article
9.Shankland SJ. 2006 The podocyte’s response to injury: role in proteinuria and glomerulosclerosis. Kidney Int. 69(12):2131-47.10.1038/sj.ki.500041016688120
Search in Google Scholar Back to article
10.Nagata M. 2016 Podocyte injury and its consequences. Kidney Int. 89(6):1221-3010.1016/j.kint.2016.01.01227165817
Search in Google Scholar Back to article
11.Lee HS, 2012 Mechanisms and consequences of TGF-ß overexpression by podocytes in progressive podocyte disease. Cell Tissue Res. 347(1):129-4010.1007/s00441-011-1169-7325061721541658
Search in Google Scholar Back to article
12.Fogo AB, 2007, Mechanisms of progression of chronic kidney disease; Pediatr Nephrol 22:2011202210.1007/s00467-007-0524-0206494217647026
Search in Google Scholar Back to article

Is Chronic Kidney Disease Reversible?

Abstract

Paradigm

My account