References
- 1. Cooper DS, Biondi B. Subclinicalthyroiddisease. Lancet 2012;379:1142–1154.10.1016/S0140-6736(11)60276-6
- 2. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, et al. Subclinicalthyroiddisease: scientific review and guidelines for diagnosis and management. JAMA 2004;291:228–238.10.1001/jama.291.2.22814722150
- 3. Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. EndocrRev 2008;29:76–131.10.1210/er.2006-004317991805
- 4. Park YJ, Lee YJ, Choi SI, Chun EJ, Jang HC, Chang HJ. Impact of subclinical hypothyroidism on the coronary artery disease in apparently healthy subjects. Eur J Endocrinol 2011;165:115–121.10.1530/EJE-11-001421490120
- 5. Kim YA, Park YJ. Prevalence and risk factors of subclinical thyroid disease. EndocrinolMetab (Seoul) 2014;29:20–29.10.3803/EnM.2014.29.1.20397028224741450
- 6. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med 2000;160:526–534.10.1001/archinte.160.4.52610695693
- 7. Kim TH, Choi HS, Bae JC, Moon JH, Kim HK, Choi SH, et al. Subclinical hypothyroidism in addition to common risk scores for prediction of cardiovascular disease: a 10-year community-based cohort study. Eur J Endocrinol 2014;171:649-657.10.1530/EJE-14-046425184283
- 8. Vanderpump MP, Tunbridge WM, French JM, Apple-ton D, Bates D, Clark F et al. The incidence of thyroid disorders in the community: a twenty year follow-up of the Whickham Survey. Clin Endocrinol (Oxf) 1995;43:55–68.10.1111/j.1365-2265.1995.tb01894.x7641412
- 9. Teng W, Shan Z, Teng X, Guan H, Li Y, Teng D et al. Effect of iodine intake on thyroid diseases in China. NEngl J Med 2006;354:2783–2793.10.1056/NEJMoa05402216807415
- 10. Al Sayed A, Al Ali N and Alfadhli E. Subclinical hypothyroidism is associated with early insulin resistance in Kuwaiti women. Endocr J 2006;53:653-657.10.1507/endocrj.K06-018
- 11. Ridker PM, RifaiN, Stampfer MJ and Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation2000;101:1767-1772.10.1161/01.CIR.101.15.176710769275
- 12. Esper RJ, Nordaby RA, Vilariño JO, Paragano A, Cacharrón JL, Machado RA. Endothelial dysfunction: a comprehensive appraisal. Cardiovasc Diabetol2006; 5:4–22.10.1186/1475-2840-5-4
- 13. Widlansky ME, Gokce N, Keaney JFJr, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol2003;42:1149–1160.10.1016/S0735-1097(03)00994-X
- 14. Frank PG, Pavlides S, Lisanti MP. Caveolae and transcytosis in endothelial cells: role in atherosclerosis. CellTissue Res2009;335:41–47.10.1007/s00441-008-0659-818688651
- 15. Tseng FY, Lin WY, Lin CC, et al. Subclinical hypothyroidism is associated with increased risk for all cause and cardiovascular mortality in adults. J Am CollCardiol 2012;60:730-737.10.1016/j.jacc.2012.03.04722726629
- 16. Gen R, Akbay E and Sezer K. Insulin resistance and cardiovascular risk factors in patient with mild and severe subclinical hypothyroidism. The Endocrinologist 2010;20:128-130.10.1097/TEN.0b013e3181dfe618
- 17. Maratou E, Hadjidakis DJ, Kollias A, et al. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol 2009;160:785-790.10.1530/EJE-08-079719141606
- 18. Peeters RP, Van DerDeure WM, Van Den Beld AW, et al. The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Clin Endocrinol (Oxf) 2007;66:808-815.10.1111/j.1365-2265.2007.02817.x17408423
- 19. XiangGD, Xiang LW, He HL and Zhao LS. Postprandial lipaemia suppresses endothelium-dependent arterial dilation in patients with hypothyroidism. Endocrine 2012;42:391-398.10.1007/s12020-012-9624-022354717
- 20. Taddei S, Caraccio N, Virdis A, et al. Low grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto’s thyroiditis. J Clin EndocrinolMetab 2006;91:5076-5082.10.1210/jc.2006-107516968790
- 21. Zhang C, Xu X, Potter BJ, et al. TNF-alpha contributes to endo-thelial dysfunction in ischemia/reperfusion injury. ArteriosclerThrombVasc Biol 2006;26:475-480.10.1161/01.ATV.0000201932.32678.7e16385082
- 22. Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A and Witteman JC. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam study. Ann Intern Med 2000;132:270-278.10.7326/0003-4819-132-4-200002150-0000410681281
- 23. Rodondi N, Newman AB, Vittinghoff E, et al. Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Arch Intern Med 2005;165:2460-2466.10.1001/archinte.165.21.246016314541
- 24. Walsh JP, Bremner AP, Bulsara MK, et al. Subclinical thyroid dysfunction as a risk factor for cardiovascular disease. Arch Intern Med 2005;165:2467-2472.10.1001/archinte.165.21.246716314542
- 25. Razvi S, Weaver JU, Vanderpump MP and Pearce SH. The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort. J Clin EndocrinolMetab 2010;95:1734-1740.10.1210/jc.2009-174920150579
- 26. Dardano A, Ghiadoni L, Plantinga Y, et al. Recombinant human thyrotropin reduces endothelium dependent vasodilation in patients monitored for differentiated thyroid carcinoma. J Clin EndocrinolMetab 2006;91:4175-4178.10.1210/jc.2006-044016868055
- 27. Kim YA, Montagnani M, Koh KK and Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction molecular and pathophysiological mechanisms. Circulation 2006;113:1888-1904.10.1161/CIRCULATIONAHA.105.56321316618833
- 28.Kvetny J, Heldgaard PE, Bladbjerg EM, Gram J. Subclinical hypothyroidism is associated with a low grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years. Clin Endocrinol (Oxf) 2004;61:232–238.10.1111/j.1365-2265.2004.02088.x15272919
- 29. Rodondi N, den ElzenWP, Bauer DC, Cappola AR, Razvi S, Walsh JP, Asvold BO, Iervasi G, Imaizumi M, Collet TH et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. Journal of the American Medical Association 2010;304:1365–1374.10.1001/jama.2010.1361392347020858880
- 30. Gencer B, Collet TH, Virgini V, Auer R &Rodondi N. Subclinical thyroid dysfunction and cardiovascular outcomes among prospective cohort studies. Endocrine, Metabolic &ImmuneDisorders Drug Targets 2013;13:4–12.10.2174/187153031131301000323369133
- 31. McQuade C, Skugor M, Brennan DM, Hoar B, Stevenson C & Hoogwerf BJ. Hypothyroidism and moderate subclinical hypothyroidism are associated with increased all-cause mortality independent of coronary heart disease risk factors: a précis database study. Thyroid 2011;21: 837–843.10.1089/thy.2010.029821745107
- 32. Taylor PN, Razvi S, Pearce SH, Dayan CM. Clinical review: a review of the clinical consequences of variation in thyroid function within the reference range. J Clin EndocrinolMetab 2013;98:3562-3571.10.1210/jc.2013-1315
- 33. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. New England Journal of Medicine 2008;358:1336-1345.10.1056/NEJMoa072100
- 34. Geng H, Zhang X, Wang C, et al. Even mildly elevated TSH is associated with an atherogenic lipid profile in postmenopausal women with subclinical hypothyroidism. Endocr Res2014;28:625-631.
- 35. Brenta G, Mutti LA, Schnitman M, Fretes O, Perrone A, Matute ML. Assessment of left ventricular diastolic function byradionuclideventriculography at rest and exercise in subclinical hypothyroidism, and its response to L-thyroxine therapy. AmJ Cardiol2003;91:1327–1330.10.1016/S0002-9149(03)00322-9
- 36. Nanchen D, Gussekloo J, Westendorp RG, Stott DJ, Jukema JW, Trompet S, et al. Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk. J Clin Endocrinol Metab2012;97:852–861.10.1210/jc.2011-197822238391
- 37. Madathil A, Hollingsworth KG, Blamire AM, Razvi S, Newton JL, Taylor R, et al. Levothyroxine improves abnormal cardiac bioenergetics in subclinical hypothyroidism: a cardiac magnetic resonance spectroscopic study. J Clin Endocrinol Metab 2015; 100: E607–E610.10.1210/jc.2014-294225541742
- 38. Iqbal A, Figenschau Y, Jorde R. Blood pressure in relation to serum thyrotropin: the Tromsø study. J HumHypertens 2006;20:932–936.10.1038/sj.jhh.100209117024137
- 39. Liu D, Jiang F, Shan Z, Wang B, Wang J, Lai Y, et al. A cross sectional survey of relationship between serum TSH level and blood pressure. J HumHypertens 2010;24:134–138.10.1038/jhh.2009.44301109419554027
- 40. Monzani F, Caraccio N, Kozakowa M, et al. Effect of levothyroxine replacement on lipid profile and intima media thickness in subclinical hypothyroidism: a double blind, placebo-controlled study. J Clin Endocrinol Metab2004;89:2099–2106.10.1210/jc.2003-03166915126526
- 41. Oner FA, Yurdakul S, Oner E, Uzum AK, Erguney M. Evaluation of the effect of L-thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism. Endocr Res2011;40:280–284.10.1007/s12020-011-9465-221505892
- 42. Cappola AR, Ladenson PW. Hypothyroidism and atherosclerosis. J Clin Endocrinol Metab 2003;88:2438–2444.10.1210/jc.2003-03039812788839
- 43. Saltiki K, Voidonikola P, Stamatelopoulos K, MantzouE, Papamichael C, AlevizakiM. Association of thyroid function with arterial pressure in normotensive and hypertensive euthyroid individuals: a cross sectional study. ThyroidRes 2008;29:3–9.10.1186/1756-6614-1-3
- 44. Iwen KA, Schroder E, Brabant G. Thyroid hormones and the metabolic syndrome. EurThyroid J 2013;2:83–92.10.1159/000351249
- 45. Nakajima Y, Yamada M, Akuzawa M, Ishii S, Masamura Y, Satoh T, et al. Subclinical hypothyroidism and indices for metabolic syndrome in Japanese women: one year followup study. J Clin EndocrinolMetab 2013;98:3280–3287.10.1210/jc.2013-1353
- 46. Suh S, Lee MK. Metabolic syndrome and cardiovascular disease in Korea. J. Atheroscler. Thromb 2014;21(Suppl 1):S31-S35.10.5551/jat.21_Sup.1-S31
- 47. Sari R, Balci MK, Altunbas H, Karayalcin U. The effect of bodyweight and weight loss on thyroid volume and function i n obese women. Cl i n Endocrinol 2003;59:258–262.10.1046/j.1365-2265.2003.01836.x
- 48. Rosenbaum M, Hirsch J, Murphy E, Leibel RL. Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function. Am J Clin Nutr 2000; 71:1421–1432.10.1093/ajcn/71.6.1421
- 49. Auwerx J, Staels B. Leptin. Lancet 1998; 351:737–742.10.1016/S0140-6736(97)06348-4
- 50. Ortiga-Carvalho TM, Oliveira KJ, Soares BA, Pazos-Moura CC. The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies. J Endocrinol 2002;174: 121–125.10.1677/joe.0.174012112098670
- 51. Ghizzoni L, Mastorakos G, Ziveri M, Furlini M, Solazzi A, Vottero A et al. Interactions of leptin and thyrotropin 24-h secretory profiles in short normal children. J Clin EndocrinolMetab 2001;86:2065–2072.10.1210/jcem.86.5.745211344208
- 52. Ye Y, Xie H, Zeng Y, Zhao X, Tian Z, Zhang S. Association between subclinical hypothyroidism and blood pressure: a meta-analysis of observational studies. EndocrPract 2014;20:150-158.10.4158/EP13237.OR24014003
- 53. Razvi S, Ingoe L, Keeka G, Oates C, McMillan C and Weaver JU: The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial. J Clin EndocrinolMetab 2007;92:1715-1723.10.1210/jc.2006-186917299073
- 54. Razvi S, Weaver JU, Butler TJ, Pearce SH. Levothyroxine treatment of subclinical hypothyroidism, fatal and nonfatal cardiovascular events, and mortality. Arch Intern Med2012;178:811–817.10.1001/archinternmed.2012.115922529180
- 55. Pasqualetti G, Tognini S, Polini A, Caraccio N, Monzani F. Is subclinical hypothyroidism a cardiovascular risk factor in the elderly? J Clin Endocrinol Metab2013;98:2256–2266.10.1210/jc.2012-381823559085