Beyond the Arteries in Peripheral Artery Disease

Alexandr Ceasovschih; Victoriţa Șorodoc; Viviana Aursulesei; Dan Tesloianu; Irina M. Jaba; Corina Dima Cozma; Bogdan M. Mihai; Cristian Stătescu; Oana Sîrbu; Alexandra Stoica; Cristina Tuchiluș; Ecaterina Anisie; Elena D. Grigorescu; Lilia Simionov; Maria Obreja; Laurenţiu Șorodoc

doi:10.2478/inmed-2018-0018

Abstract

Objectives. This study aimed to examine peripheral artery disease severity impact on psychological profile of arteriopathy patients.

Material and methods. The prospective study included consecutive PAD patients admitted to the 2^nd Department of Internal Medicine and the Department of Cardiology of the Emergency Clinical Hospital “Sf. Spiridon” Iasi, between January and September, 2017.

Rezults. The group included 139 PAD patients, 80.6% male and 19.4% female, with an average age of 63.23±9.44 years. PAD stages have a very strong association with level of quality of life (p<0.0001). All Leriche-Fontaine classification categories were significantly associated with the depressive symptoms (p<0.0001). The stress level was moderate in stages IIA, IIB and III and extremely severe in the terminal stage. The prevalence of anxiety was lowest in incipient PADstages with the highest value in stage III.

Conclusions. The fragment of the PhD study presented the psychological profile in the PAD staging and advocates a personalized, wide-ranging approach to the arteriopathy patient including pain and depressive-anxiety management, with amajor impact on the quality of life at terminal stages.

References

1. Aboyans V., Ricco J.B., Bartelink M.E.L. et al. 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery. Eur Heart J, 2018: 39(9): 763-816.10.1093/eurheartj/ehy045
Search in Google Scholar Back to article
2. Gerhard-Herman M.D., Gornik H.L., Barrett C., et al. 2016 AHA/ACC Guideline on the Management of Patients with Lower Extremity Peripheral Artery Disease: Executive Summary. Circulation, 2017; 135 (12): e726-e779.
Search in Google Scholar Back to article
3. Aboyans V., Sevestre M.A., Désormais I., et al. Épidémiologie de l’artériopathie des membres inférieurs. Presse Med, 2018; https://doi.org/10.1016/j.lpm.2018.01.012.10.1016/j.lpm.2018.01.01229449058
Open DOI Search in Google Scholar Back to article
4. Fowkes F.G., Aboyans V., Fowkes F.J., et al. Peripheral artery disease: epidemiology and global perspectives, 2016; doi:10.1038/nrcardio.2016.17910.1038/nrcardio.2016.17927853158
Open DOI Search in Google Scholar Back to article
5. Aber A., Lumley E., Phillips P., et al. Themes that Determine Quality of Life in Patients with Peripheral Arterial Disease: A Systematic Review. Patient, 2018; doi.org/10.1007/s40271-018-0307-7.10.1007/s40271-018-0307-729736612
Open DOI Search in Google Scholar Back to article
6. Conte S.M., Vale P.R. Peripheral Arterial Disease. Heart, Lung and Circulation, 2017; https://doi.org/10.1016/j.hlc.2017.10.014.10.1016/j.hlc.2017.10.01429150158
Open DOI Search in Google Scholar Back to article
7. Morley R.L., Sharma A., Horsch A.D., et al. Peripheral Arterial Disease. BMJ, 2018; doi: 10.1136/bmj.j5842.10.1136/bmj.j584229419394
Open DOI Search in Google Scholar Back to article
8. Davie-Smith F., Coulter E., Kennon B., et al. Factors influencing quality of life following lower limb amputation for peripheral arterial occlusive disease: A systematic review of the literature. Prosthetics and Orthotics International, 2017; 41 (6): 537-547.10.1177/030936461769039428147898
Search in Google Scholar Back to article
9. Smolderen K.G., Hoeks S.E., Pedersen S.S., et al. Lower-leg symptoms in peripheral arterial disease are associated with anxiety, depression, and anhedonia. Vascular Medicine, 2009; 14: 297–304.10.1177/1358863X0910465819808714
Open DOI Search in Google Scholar Back to article
10. Arya S., Lee S., Zahner G.J., et al. The association of comorbid depression with mortality and amputation in veterans with peripheral artery disease. J Vasc Surg, 2018; doi.org/10.1016/j.jvs.2017.10.09210.1016/j.jvs.2017.10.092605781829588133
Search in Google Scholar Back to article
11. de Almeida Correia M., Andrade-Lima A., Mesquita de Oliveira P.L., et al. Translation And Validation Of The Brazilian-Portuguese Short Version Of Vascular Quality Of Life Questionnaire In Peripheral Artery Disease Patients With Intermittent Claudication Symptoms, Annals of Vascular Surgery, 2018; doi: 10.1016/j.avsg.2018.02.026.10.1016/j.avsg.2018.02.02629772330
Open DOI Search in Google Scholar Back to article
12. Harwood A.E., Totty J. P., Broadbent E., et al. Quality of life in patients with intermittent claudication. Gefässchirurgie, 2017; 22: 159–164.10.1007/s00772-017-0269-4541352528529410
Search in Google Scholar Back to article
13. Wu A., Coresh J., Selvin E., et al. Lower Extremity Peripheral Artery Disease and Quality of Life Among Older Individuals in the Community. J Am Heart Assoc, 2017; 6: e004519. doi: 10.1161/JAHA.116.004519.10.1161/JAHA.116.004519552363528108464
Open DOI Search in Google Scholar Back to article
14. Brostow D.P., Petrik M.L., Starosta A.J., Waldo W.S. Depression in patients with peripheral arterial disease: A systematic review. European Journal of Cardiovascular Nursing, 2017; 16(3): 181–193.10.1177/147451511668722228051339
Open DOI Search in Google Scholar Back to article
15. Grenon S.M., Hiramoto J., Smolderen K.G., et al. Association Between Depression and Peripheral Artery Disease: Insights From the Heart and Soul Study. J Am Heart Assoc, 2012; 1:e002667, doi: 10.1161/JAHA.112.00266710.1161/JAHA.112.002667348734823130170
Open DOI Search in Google Scholar Back to article
16. Gardner A.W.,Waldstein S.R., Montgomery P.S., et al. Effect of cognitive status on exercise performance and quality of life in patients with symptomatic peripheral artery disease. J Vasc Surg, 2016; 63 (1): 98–104.10.1016/j.jvs.2015.08.064469801326474509
Search in Google Scholar Back to article
17. Wright C.E., Strike P.C., Brydon L., Steptoe A. Acute inflammation and negative mood: mediation by cytokine activation. Brain Behav Immun, 2005; 19: 345–350.10.1016/j.bbi.2004.10.00315944074
Open DOI Search in Google Scholar Back to article
18. Irwin M. Psychoneuroimmunology of Depression: Clinical Implications. Brain, Behavior, and Immunity, 2002; 16: 1–16.10.1006/brbi.2001.065411846437
Open DOI Search in Google Scholar Back to article
19. Ustundag H., Gul A., Findik U.Y. Quality of Life and Pain in Patients with Peripheral Arterial Disease. International J of Caring Science, 2016; 9 (3): 838-845.
Search in Google Scholar Back to article
20. McDermott M.M., Guralnik J.M., Tian L., et al. Incidence and Prognostic Significance of Depressive Symptoms in Peripheral Artery Disease. J Am Heart Assoc. 2016; 5:e002959 doi: 10.1161/JAHA.115.00295910.1161/JAHA.115.002959494327026994131
Open DOI Search in Google Scholar Back to article
21. Lindgren H., Qvarfordt P., Bergman S., et al. Primary Stenting of the Superficial Femoral Artery in Patients with Intermittent Claudication Has Durable Effects on Health-Related Quality of Life at 24 Months: Results of a Randomized Controlled Trial. Cardiovasc Intervent Radiol, 2018; 41 (6): 872–881.10.1007/s00270-018-1925-0593786429520431
Search in Google Scholar Back to article

Beyond the Arteries in Peripheral Artery Disease

Abstract

Paradigm

My account