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An update on the GE (Gerbich) blood group system Cover

An update on the GE (Gerbich) blood group system

Paid access
|Apr 2026

References

  1. Rosenfield RE, Haber GV, Kissmeyer-Nielsen F, Jack JA, Sanger R, Race RR. Ge, a very common red-cell antigen. Br J Haematol 1960;6:344–9.
  2. Walker PS, Reid ME. The Gerbich blood group system: a review. Immunohematology 2010;26:60–5.
  3. ISBT Working Party Red Cell Immunogenetics and Blood Group Terminology. Gerbich [GE] system information. Available from https://blooddatabase.isbtweb.org/system/GE. Accessed 12 August 2025.
  4. Jumper J, Evans R, Pritzel A, et al. Highly accurate protein structure prediction with AlphaFold. Nature 2021;596:583–9. doi: 10.1038/s41586-021-03819-2.
  5. Fleming J, Magana P, Nair S, et al. AlphaFold Protein Structure database and 3D-Beacons: new data and capabilities. J Mol Biol 2025;437:168967. doi: 10.1016/j.jmb.2025.168967.
  6. Gassner C, Scherer V, Zanolin-Purin D, Scharberg EA, Flesch B. Occurrence of rare deletional Yus and Gerbich alleles in Syria and neighbouring countries. Transfus Med Hemother 2022;49:358–67. doi: 10.1159/000524249.
  7. Patel SS, Mehlotra RK, Kastens W, Mgone CS, Kazura JW, Zimmerman PA. The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea. Blood 2001;98:3489–91. doi: 10.1182/blood.v98.12.3489.
  8. Jaskiewicz E, Peyrard T, Kaczmarek R, Zerka A, Jodlowska M, Czerwinski M. The Gerbich blood group system: old knowledge, new importance. Transfus Med Rev 2018;32:111–6. doi: 10.1016/j.tmrv.2018.02.004.
  9. Telen MJ, Le Van Kim C, Chung A, Cartron JP, Colin Y. Molecular basis for elliptocytosis associated with glycophorin C and D deficiency in the Leach phenotype. Blood 1991;78: 1603–6.
  10. Reynolds MV, Vengelen-Tyler V, Morel PA. Autoimmune hemolytic anemia associated with autoanti-Ge. Vox Sang 1981;41:61–7. doi: 10.1111/j.1423-0410.1981.tb01015.x.
  11. Lomas-Francis C, Tahiri T, Vege S, et al. GECT: a new high-prevalence antigen in the GE blood group system in a SCD patient with an apparent anti-GE2. Transfusion 2020;60(Suppl 5):7A–260A.
  12. Shakarian G, Ong J, Vege S, et al. A new antibody in the Gerbich blood system against a novel high prevalence antigen named GEAR. Transfusion 2016;56(Suppl 4):3A–275A.
  13. Poole J, Tilly, Hudler P, et al. Novel mutations in GYPC giving rise to lack of ge epitopes and anti Ge production. Vox Sang 2008;95(Suppl 1):181.
  14. Jakobsen MA, Dellgren C, Sheppard C, Yazer M, Sprogøe U. The use of next-generation sequencing for the determination of rare blood group genotypes. Transfus Med 2019;29:162–8. doi: 10.1111/tme.12496.
  15. Gleadall NS, Koets L, Shamardina O, et al. Array genotyping of transfusion relevant blood cell antigens in 6946 ancestrally diverse subjects. Blood 2025;146:1511–24. doi: 10.1182/blood.2025028902.
  16. Gourri E, Denomme GA, Merki Y, et al. Genetic background of the rare Yus and Gerbich blood group phenotypes: homologous regions of the GYPC gene contribute to deletion alleles. Br J Haematol 2017;177:630–40. doi: 10.1111/bjh.14578.
  17. Petermann S, Mayer V, Carbol A, Opitz A, Flesch BK. Compound heterozygosity induces a rare Gerbich-negative phenotype in an immunized blood donor. Transfusion 2024;64:406–11. doi: 10.1111/trf.17711.
  18. Mochizuki T, Tauxe WN, Ramsey G. In vivo crossmatch by chromium-51 urinary excretion from labeled erythrocytes: a case of anti-Gerbich. J Nucl Med 1990;31:2042–4.
  19. Hildebrandt M, Hell A, Etzel F, Genth R, Salama A. Determination and successful transfusion of anti-Gerbich-positive red blood cells in a patient with a strongly reactive anti-Gerbich antibody. Infusionsther Transfusionsmed 2000; 27:154–6.
  20. Selleng S, Selleng K, Zawadzinski C, Wollert HG, Yürek S, Greinacher A. Management of emergency cardiac surgery in a patient with alloanti-Ge2. Transfus Med 2009;19:50–2.
  21. Singh RP. Antibodies against high frequency Gerbich 2 antigen (anti-Ge2): a real challenge in cross matching lab. Asian J Transfus Sci 2013;7:88–9. doi: 10.4103/0973-6247.106758.
  22. ISBT Working Party Rare Donors. Outcome of antigen positive transfusion form. Available from www.isbtweb.org/resource/outcomeantigenpositivetransfusionform.html. Accessed 12 August 2025.
  23. Baughn MR, Whitacre P, Lo GS, Pandey S, Lane TA. A mild acute hemolytic transfusion reaction in a patient with alloanti-Ge3: a case report and review of the literature. Transfusion 2011;51:1966–71. doi: 10.1111/j.1537-2995.2011.03093.x.
  24. Wright T, Brown P, Marais I, Hong FS. Acute haemolytic reaction due to anti-Wb: a case report. Vox Sang 2013;105:355–7. doi: 10.1111/vox.12052.
  25. Pate LL, Myers JC, Palma JP, et al. Anti-Ge3 causes late-onset hemolytic disease of the newborn: the fourth case in three Hispanic families. Transfusion 2013;53:2152–7. doi: 10.1111/trf.12027.
  26. Levitt RN, Gourri E, Gassner C, et al. Molecular characterization and multidisciplinar y management of Gerbich hemolytic disease of the newborn. Pediatr Blood Cancer 2018;65:e27014. doi: 10.1002/pbc.27014.
  27. Arndt PA, Garratty G, Daniels G, et al. Late onset neonatal anaemia due to maternal anti-Ge: possible association with destruction of ey throid progenitors. Transfus Med 2005;15:125–32. doi: 10.1111/j.0958-7578.2005.00562.x.
  28. Blackall DP, Pesek GD, Montgomery MM, et al. Hemolytic disease of the fetus and newborn due to anti-Ge3: combined antibody dependent hemolysis and erythroid precursor cell growth inhibition. Am J Perinatol 2008;25:541–5. https://doi.org/10.1055/s-0028-1085072.
  29. Lomas-Francis C, Burgos A, Dombourian MG, et al. The first report of anti-Dha (anti-GE8) implicated in severe anemia of the fetus and newborn in two consecutive pregnancies. Vox Sang 2016;111(Suppl 1):46.
  30. Klei TRL, de Back DZ, Asif PJ, et al. Glycophorin-C sialylation regulates Lu/BCA M adhesive capacity during erythrocyte aging. Blood Adv 2018 3;2:14–24. doi: 10.1182/bloodadvances.2017013094.
  31. Klei TRL, Dalimot JJ, Beuger BM, et al. The Gardos effect drives erythrocyte senescence and leads to Lu/BCAM and CD44 adhesion molecule activation. Blood Adv 2020;4:6218–29. doi: 10.1182/bloodadvances.2020003077.
  32. Tanaka S, Takakuwa Y. Intracellular interactions between protein 4.1 and glycophorin C on transport vesicles, as determined by fluorescence correlation spectroscopy. FEBS Lett 2012;586:668–74. doi: 10.1016/j.febslet.2012.01.058.
  33. Rydzak J, Kmiecik AM, Jaśkiewicz E. [Human erythrocyte glycophorin C as the receptor for EBA-140 plasmodium falciparum merozoite ligand] (in Polish). Postepy Hig Med Dosw 2013;67:1331–9. doi: 10.5604/17322693.1081865.
  34. Malpede BM, Lin DH, Tolia NH. Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140/BAEBL. J Biol Chem 2013;288:12406–15. doi: 10.1074/jbc. M113.450643.
  35. Ashline DJ, Duk M, Lukasiewicz J, Reinhold VN, Lisowska E, Jaskiewicz E. The structures of glycophorin C N-glycans, a putative component of the GPC receptor site for Plasmodium falciparum EBA-140 ligand. Glycobiology 2015;25:570–81. doi: 10.1093/glycob/cwu188.
  36. Rydzak J, Kaczmarek R, Czerwinski M, et al. The baculovirus-expressed binding region of Plasmodium falciparum EBA-140 ligand and its glycophorin C binding specificity. PLoS One 2015;10:e0115437. doi: 10.1371/journal.pone.0115437.
  37. Jaskiewicz E, Jodłowska M, Kaczmarek R, Zerka A. Erythrocyte glycophorins as receptors for Plasmodium merozoites. Parasit Vectors 2019;12:317. doi: 10.1186/s13071-019-3575-8.
  38. Lin E, Tavul L, Michon P, et al. Minimal association of common red blood cell polymorphisms with Plasmodium falciparum infection and uncomplicated malaria in Papua New Guinean school children. Am J Trop Med Hyg 2010;83:828–33. doi: 10.4269/ajtmh.2010.09-0713.
  39. Lee WC, Malleret B, Lau YL, et al. Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes. Blood 2014; 123:e100–9. doi: 10.1182/blood-2013-12-541698.
  40. Niang M, Bei AK, Madnani KG, et al. STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting. Cell Host Microbe 2014;16:81–93. doi: 10.1016/j.chom.2014.06.004.
  41. Yiangou L, Montandon R, Modrzynska K, et al. A stem cell strategy identifies glycophorin C as a major erythrocyte receptor for the rodent malaria parasite Plasmodium berghei. PLoS One 2016;11:e0158238. doi: 10.1371/journal. pone.0158238.
  42. Zerka A, Kaczmarek R, Czer winski M, Jaskiewicz E. Plasmodium reichenowi EBA-140 merozoite ligand binds to glycophorin D on chimpanzee red blood cells, shedding new light on origins of Plasmodium falciparum. Parasit Vectors 2017;10:554. doi: 10.1186/s13071-017-2507-8.
  43. Jajosky RP, Jajosky AN, Jajosky PG. Therapeutically-rational exchange (T-REX) of Gerbich-negative red blood cells can be evaluated in Papua New Guinea as “a rescue adjunct” for patients with Plasmodium falciparum malaria. Ther Apher Dial 2021;25:242–7. doi: 10.1111/1744-9987.13551.
DOI: https://doi.org/10.2478/immunohematology-2026-005 | Journal eISSN: 1930-3955 | Journal ISSN: 0894-203X
Language: English
Page range: 16 - 21
Published on: Apr 10, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2026 Peter C. Ligthart, Barbera Veldhuisen, published by American National Red Cross
This work is licensed under the Creative Commons License.