The Rh blood group system: RHD update

Glenn Ramsey

doi:10.2478/immunohematology-2025-007

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The Rh blood group system: RHD update

Immunohematology

Volume 41 (2025): Issue 2 (June 2025)

By: Glenn Ramsey

Paid access

|Jul 2025

❗ Available for purchase in USD only.

Abstract

The Rh blood group system was last reviewed in Immunohematology in 2010 (Chou ST, Westhoff CM. The Rh and RhAG blood group systems. Immunohematology 2010;26:178–86). This update focuses on RHD, RhD structure, alterations in D expression, anti-D alloimmunization, and applications of RHD genotyping for weak and discrepant D phenotypes; identification of RHD genotypes that encode partial D phenotypes; and prevention and management of anti-D in pregnancy. Updates to the RHAG system and to RHCE and its encoded antigens are in recent or upcoming publications of Immunohematology, respectively.

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