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An update on the RHAG blood group system Cover

An update on the RHAG blood group system

Open Access
|Mar 2025

References

  1. Chou ST, Westhoff CM. The Rh and RhAG blood group systems. Immunohematology 2010;26:178–86.
  2. Storry JR, Clausen FB, Castilho L, et al. International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology: Report of the Dubai, Copenhagen and Toronto meetings. Vox Sang 2019:114:95–102.
  3. Chou ST, Flanagan JM, Vege S, et al. Whole-exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia. Blood Adv 2017;1:1414–22.
  4. Ichikawa Y, Sata C, McCreary J, Lubenko A. Kg, a new low-frequency red cell antigen responsible for hemolytic disease of the newborn. Vox Sang 1989;56:98–100.
  5. Tanaka M, Abe T, Minamitani T, et al. The Kg-antigen, RhAG with a Lys164Gln mutation, gives rise to haemolytic disease of the newborn. Br J Haematol 2020:191:920–6.
  6. Tilley L, Green C, Poole J, et al. A new blood group system, RHAG: three antigens resulting from amino acid substitutions in the Rh-associated glycoprotein. Vox Sang 2010;98:151–9.
  7. Miyazaki T, Isa K, Kurita R, et al. DSLK and Kg: antithetical antigens in the RHAG blood group system, and characterization of anti-DSLK antibody. Vox Sang 2023;118:392–7.
  8. Gonzalez-Santesteban C, Nogues N, Boto Ruiz N, et al. Identification of a new low prevalence antigen in the RHAG glycoprotein [abstract]. Vox Sang 2022;117(Suppl 1):55–6.
  9. Long S, Millard G, Liew YW, et al. Haemolytic disease of the fetus and newborn caused by a novel RhAG antigen with c.140T>C (p.Phe47Ser) missense mutation [abstract]. Transfus Med 2022;32(Suppl 3):29–30.
  10. Chatterjee S, Millard G, Chiawchan S, et al. A case of haemolytic disease of the fetus and newborn attributed to a novel antigen in the RHAG blood group system. Vox Sang 2023;118:1095–9.
  11. Dobson L, Reményi I, Tusnády GE. The human transmembrane proteome. Biol Direct 2015;10:31.
  12. International Society of Blood Transfusion (ISBT). Red cell immunogenetics and blood group terminology. Blood group allele tables 030 RHAG alleles. Available from https://www.isbtweb.org/resource/030rhag.html. Accessed 23 August 2024.
  13. Floch A, Galochkina T, Pirenne F, Tournamille C, de Brevern AG. Molecular dynamics of the human RhD and RhAG blood group proteins. Front Chem 2024;12:1360392.
  14. Vallese F, Kim K, Yen LY, et al. Architecture of the human erythrocyte ankyrin-1 complex. Nat Struct Mol Biol 2022; 29:706–18.
  15. Ripoche P, Bertrand O, Gane P, Birkenmeier C, Colin Y, Cartron JP. Human Rhesus-associated glycoprotein mediates facilitated transport of NH(3) into red blood cells. Proc Natl Acad Sci USA 2004;101:17222–7.
  16. Geyer RR, Parker MD, Toye AM, Boron WF, Musa-Aziz R. Relative CO2/NH3 permeabilities of human RhAG, RhBG and RhCG. J Membr Biol 2013;246:915–26.
  17. Stewart GW, Gibson JS, Rees DC. The cation-leaky hereditary stomatocytosis syndromes: a tale of six proteins. Br J Haematol 2023;203:509–22.
DOI: https://doi.org/10.2478/immunohematology-2025-002 | Journal eISSN: 1930-3955 | Journal ISSN: 0894-203X
Language: English
Page range: 1 - 3
Published on: Mar 26, 2025
Published by: American National Red Cross
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Louise A. Tilley, published by American National Red Cross
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.