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Explainable AI for binary and multi-class classification of leukemia using a modified transfer learning ensemble model Cover

Explainable AI for binary and multi-class classification of leukemia using a modified transfer learning ensemble model

Open Access
|Mar 2024

Figures & Tables

Figure 1:

(a) Normal cells; and (b) leukemia cells [9].
(a) Normal cells; and (b) leukemia cells [9].

Figure 2:

Proposed methodology for leukemia diagnosis. LIME, Local Interpretable Model-Agnostic Explanations; XAI, explainable artificial intelligence.
Proposed methodology for leukemia diagnosis. LIME, Local Interpretable Model-Agnostic Explanations; XAI, explainable artificial intelligence.

Figure 3:

VGG-16 architecture.
VGG-16 architecture.

Figure 4:

Asymmetric convolutions.
Asymmetric convolutions.

Figure 5:

Auxiliary classifiers.
Auxiliary classifiers.

Figure 6:

Grid size reduction.
Grid size reduction.

Figure 7:

Final model architecture of inceptionv3.
Final model architecture of inceptionv3.

Figure 8:

(a) ALL-IDB-1 infected image; (b) ALL-IDB-1 normal image; (c) ALL-IDB2 infected image, and (d) ALL-IDB2 normal image.
(a) ALL-IDB-1 infected image; (b) ALL-IDB-1 normal image; (c) ALL-IDB2 infected image, and (d) ALL-IDB2 normal image.

Figure 9:

Images from the real-image dataset: (a) CLL, (b) CML, and (c) AML. AML, acute myeloid leukemia; CLL, chronic lymphocytic leukemia; CML, chronic myeloid leukemia.
Images from the real-image dataset: (a) CLL, (b) CML, and (c) AML. AML, acute myeloid leukemia; CLL, chronic lymphocytic leukemia; CML, chronic myeloid leukemia.

Figure 10:

Training and validation accuracies: (a) modified VGG-16; (b) modified Inception; and (c) ensemble model of modified InceptionNet and VGG-16 classifiers for binary classification.
Training and validation accuracies: (a) modified VGG-16; (b) modified Inception; and (c) ensemble model of modified InceptionNet and VGG-16 classifiers for binary classification.

Figure 11:

Training and validation accuracies: (a) Modified VGG-16; (b) Modified Inception; and (c) Ensemble model of modified InceptionNet and VGG-16 Classifier for multi-class classification.
Training and validation accuracies: (a) Modified VGG-16; (b) Modified Inception; and (c) Ensemble model of modified InceptionNet and VGG-16 Classifier for multi-class classification.

Figure 12:

Comparing the model accuracy with SOTA.
Comparing the model accuracy with SOTA.

Figure 13:

(a, c, e, g) Original dataset images; and (b, d, f, h) LIME interpretation results. LIME, Local Interpretable Model-Agnostic Explanations.
(a, c, e, g) Original dataset images; and (b, d, f, h) LIME interpretation results. LIME, Local Interpretable Model-Agnostic Explanations.

Metrics showing performance metric of binary and multi-class classification_

DL classifier algorithmClass/datasetMaximum training accuracy (%)Maximum validation accuracy (%)
Modified VGG-16 classifierBinary (ALL-IDB)98.5068.33
Modified InceptionNet classifier98.5078.33
Ensemble classifier94.5083.33
Modified VGG-16 classifierMulti-class (real-images)98.5693.20
Modified InceptionNet classifier99.7697.87
Ensemble classifier100100

Comparison of the proposed approach with popular SOTA_

Advantage criteriaEnsemble (VGG-16 + inception)Pre-trained VGG-16Pre-trained inceptionRandom forestSVMResNet50 (deep learning)EfficientNet (deep learning)
Diversity in featuresYesNoYesYesNoYesYes
Generalization performanceGoodGoodGoodGoodGoodExcellentExcellent
Robustness to overfittingHighHighHighHighModerateHighHigh
Ensemble averaging benefitYesNoNoNoNoNoNo
Feature learning capabilitiesRichDeep hierarchicalDiverseModerateLinearDeep hierarchicalDiverse
State-of-the-art performanceYesNo (dated architecture)Yes (at the time)NoNoYesYes (as of the time of training)
Language: English
Submitted on: Sep 7, 2023
Published on: Mar 6, 2024
Published by: Professor Subhas Chandra Mukhopadhyay
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2024 Nilkanth Mukund Deshpande, Shilpa Gite, Biswajeet Pradhan, published by Professor Subhas Chandra Mukhopadhyay
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.