Have a personal or library account? Click to login

Spaceflight Effects and Molecular Responses in the Mouse Eye: Preliminary Observations After Shuttle Mission STS-133

Open Access
|Jul 2013

References

  1. Abramoff, M.D., Magalhaes, P.J., and Ram, S.J. 2004. Image processing with ImageJ. Biophotonics International. 11: 36-42.
  2. Awasthi, N. and Wagner, B.J. 2005. Upregulation of heat shock protein expression by proteasome inhibition: an antiapoptotic mechanism in the lens. Investigative Ophthalmology & Visual Science. 46: 2082-2091.
  3. Byun, J., Verardo, M.R., Sumengen, B., Lewis, G.P., Manjunath, B.S., and Fisher, S.K. 2006. Automated tool for the detection of cell nuclei in digital microscopic images: application to retinal images. Molecular Vision. 12: 949-960.
  4. Chen, D., Pacal, M., Wenzel, P., Knoepfler, P.S., Leone, G., and Bremner, R. 2009. Division and apoptosis of E2f-deficient retinal progenitors. Nature. 462: 925-929.
  5. Cucinotta, F.A., Manuel, F.K., Jones, J., Iszard, G., Murrey, J., Djojonegro, B., and Wear, M. 2001. Space radiation and cataracts in astronauts. Radiation Research. 156: 460-466.
  6. D’Amelio, M., Cavallucci, V., and Cecconi, F. 2010. Neuronal caspase-3 signaling: not only cell death. Cell Death & Differentiation. 17: 1104-1114.
  7. Friedman, D.I. 2007. Idiopathic intracranial hypertension. Current Pain and Headache Reports. 11: 62-68.
  8. Frigeri, A., Iacobas, D.A., Iacobas, S., Nicchia, G.P., Desaphy, J.F., Camerino, D.C., Svelto, M., and Spray, D.C. 2008. Effect of microgravity on gene expression in mouse brain. Experimental Brain Research. 191: 289-300.
  9. Gerhardinger, C., Dagher, Z., Sebastiani, P., Park, Y.S., and Lorenzi, M. 2009. The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy. Diabetes. 58: 1659-1667.
  10. Gleckman, A.M., Evans, R.J., Bell, M.D., and Smith, T.W. 2000. Optic nerve damage in shaken baby syndrome: detection by beta-amyloid precursor protein immunohistochemistry. Archives of Pathology & Laboratory Medicine. 124: 251-256.
  11. Godley, B.F., Jin, G.F., Guo, Y.S, and Hurst, J.S. 2002. Bcl-2 overexpression increases survival in human retinal pigment epithelial cells exposed to H(2)O(2). Experimental Eye Research. 74: 663-669.
  12. Hargens, A.R. and Watenpaugh, D.E. 1996. Cardiovascular adaptation to spaceflight. Medicine and Science in Sports and Exercise. 28: 977-982.
  13. Iwata, A., Chen, X.H., McIntosh, T.K., Browne, K.D., and Smith, D.H. 2002. Long-term accumulation of amyloid-beta in axons following brain trauma without persistent upregulation of amyloid precursor protein genes. Journal of Neuropathology & Experimental Neurology. 61: 1056-1068.
  14. Jaliffa, C., Ameqrane, I., Dansault, A., Leemput, J., Vieira, V., Lacassagne, E., Provost, A., Bigot, K., Masson, C., Menasche, M., and Abitbol, M. 2009. Sirt1 involvement in rd10 mouse retinal degeneration. Investigative Ophthalmology & Visual Science. 50: 3562-3572.
  15. Justilien, V., Pang, J.J., Renganathan, K., Zhan, X., Crabb, J.W., Kim, S.R., Sparrow, J.R., Hauswirth, W.W., and Lewin, A.S. 2007. SOD2 knockdown mouse model of early AMD. Investigative Ophthalmology & Visual Science. 48: 4407-4420.
  16. Kipfer-Kauer, A., McKinnon, S.J., Frueh, B.E., and Goldblum, D. 2010. Distribution of amyloid precursor protein and amyloid-beta in ocular hypertensive C57BL/6 mouse eyes. Current Eye Research. 35: 828-834.
  17. Kramer, L.A., Sargsyan, A.E., Hasan, K.M., Polk, J.D., and Hamilton, D.R. 2012. Orbital and intracranial effects of microgravity: findings at 3-T MR imaging. Radiology. 263(3): 819-27.
  18. Lamoke, F., Ripandelli, G., Webster, S., Montemari, A., Maraschi, A., Martin, P., Marcus, D.M., Liou, G.I., and Bartoli, M. 2012. Loss of thioredoxin function in retinas of mice overexpressing amyloid beta. Free Radical Biology and Medicine. 53: 577-588.
  19. LaVail, M.M., Gorrin, G.M., and Repaci, M.A. 1987. Strain differences in sensitivity to light-induced photoreceptor degeneration in albino mice. Current Eye Research. 6: 825-834.
  20. Lewis, G.P. and Fisher, S.K. 2003. Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression. International Review of Cytology. 230: 263-290.
  21. Liman, J., Faida, L., Dohm, C.P., Reed, J.C., Bahr, M., and Kermer, P. 2008. Subcellular distribution affects BAG1 function. Brain Research. 1198: 21-26.
  22. Lohr, H.R., Kuntchithapautham, K., Sharma, A.K., and Rohrer, B. 2006. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Experimental Eye Research. 83: 380-389.
  23. Mader, T.H., Gibson, C.R., Pass, A.F., Kramer, L.A., Lee, A.G., Fogarty, J., Tarver, W.J., Dervay, J.P., Hamilton, D.R., Sargsyan, A., Phillips, J.L., Tran, D., Lipsky, W., Choi, J., Stern, C., Kuyumjian, R., and Polk, J.D. 2011. Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology. 118: 2058-2069.
  24. Naidu, S., Winget, C.M., Jenner, J.W., Mele, G., and Holley, D.C. 1995. Effects of housing density on mouse physiology and behavior in the NASA Animal Enclosure Module simulators. Journal of Gravitational Physiology. 2: 140.
  25. Nakamura, S., Shibuya, M., Nakashima, H., Hisamura, R., Masuda, N., Imagawa, T., Uehara, M., and Tsubota, K. 2007. Involvement of oxidative stress on corneal epithelial alterations in a blink-suppressed dry eye. Investigative Ophthalmology & Visual Science. 48: 1552-1558.
  26. NASA. 2010. Longitudinal Study of Astronaut Health database.
  27. Oldham, K.M., Wise, S.R., Chen, L., Stacewicz-Sapuntzakis, M., Burns, J., and Bowen, P.E. 2002. A longitudinal evaluation of oxidative stress in trauma patients. Journal of Parenteral and Enteral Nutrition. 26: 189-197.
  28. Ozawa, Y., Kubota, S., Narimatsu, T., Yuki, K., Koto, T., Sasaki, M., and Tsubota, K. 2010. Retinal aging and sirtuins. Ophthalmic Research. 44: 199-203.
  29. Parsons, J.T., Bova, F.J., Mendenhall, W.M., Million, R.R., and Fitzgerald, C.R. 1996. Response of the normal eye to high dose radiotherapy. Oncology. 10: 837-847; discussion 847-838, 851-832.
  30. Philpott, D.E., Corbett, R., Turnbill, C., Black, S., Dayhoff, D., McGourty, J., Lee, R., Harrison, G., and Savick, L. 1980. Retinal changes in rats flown on Cosmos 936: A cosmic ray experiment. Aviation, Space, and Environmental Medicine. 51: 556-562.
  31. Philpott, D.E., Corbett, R., Turnbill, C., Harrison, G., Leaffer, D., Black, S., Sapp, W., Klein, G., and Savik, L.F. 1978. Cosmic ray effects on the eyes of rats flown on Cosmos No. 782, experimental K-007. Aviation, Space, and Environmental Medicine. 49: 19-28.
  32. Pierce, J.E., Trojanowski, J.Q., Graham, D.I., Smith, D.H., and McIntosh, T.K. 1996. Immunohistochemical characterization of alterations in the distribution of amyloid precursor proteins and beta-amyloid peptide after experimental brain injury in the rat. Journal of Neuroscience. 16: 1083-1090.
  33. Pietsch, J., Bauer, J., Egli, M., Infanger, M., Wise, P., Ulbrich, C., and Grimm, D. 2011. The effects of weightlessness on the human organism and mammalian cells. Current Molecular Medicine. 11: 350-364.
  34. Pulsinelli, W.A., Brierley, J.B., and Plum, F. 1982. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Annals of Neurology. 11: 491-498.
  35. Roberts, J.E., Kukielczak, B.M., Chignell, C.F., Sik, B.H., Hu, D.N., and Principato, M.A. 2006. Simulated microgravity induced damage in human retinal pigment epithelial cells. Molecular Vision. 12: 633-638.
  36. Sannita, W.G., Narici, L., and Picozza, P. 2006. Positive visual phenomena in space: A scientific case and a safety issue in space travel. Vision Research. 46: 2159-2165.
  37. Smith, D.H., Chen, X.H., Nonaka, M., Trojanowski, J.Q., Lee, V.M., Saatman, K.E., Leoni, M.J., Xu, B.N., Wolf, J.A., and Meaney, D.F. 1999. Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig. Journal of Neuropathology & Experimental Neurology. 58: 982-992.
  38. Song, D., Song, Y., Hadziahmetovic, M., Zhong, Y., and Dunaief, J.L. 2012. Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina. Free Radical Biology and Medicine. 53: 64-71.
  39. Sparrow, J.R., Nakanishi, K., and Parish, C.A. 2000. The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Investigative Ophthalmology & Visual Science. 41: 1981-1989.
  40. Stein, T.P. 2002. Space flight and oxidative stress. Nutrition. 18: 867-871.
  41. Sundaresan, A. and Pellis, N.R. 2009. Cellular and genetic adaptation in low-gravity environments. Annals of the New York Academy of Sciences. 1161: 135-146.
  42. Tanito, M., Nishiyama, A., Tanaka, T., Masutani, H., Nakamura, H., Yodoi, J., and Ohira, A. 2002. Change of redox status and modulation by thiol replenishment in retinal photooxidative damage. Investigative Ophthalmology & Visual Science. 43: 2392-2400.
  43. Tanito, M., Takanashi, T., Kaidzu, S., Yoshida, Y., and Ohira, A. 2003. Cytoprotective effects of rebamipide and carteolol hydrochloride against ultraviolet B-induced corneal damage in mice. Investigative Ophthalmology & Visual Science. 44: 2980-2985.
  44. Tombran-Tink, J. and Barnstable, C.J. 2006. Space flight environment induces degeneration in the retina of rat neonates. Advances in Experimental Medicine and Biology. 572: 417-424.
  45. Ueta, T., Inoue, T., Furukawa, T., Tamaki, Y., Nakagawa, Y., Imai, H., and Yanagi, Y. 2012. Glutathione peroxidase 4 is required for maturation of photoreceptor cells. Journal of Biological Chemistry. 287: 7675-7682.
  46. van Wijngaarden, P., Brereton, H.M., Coster, D.J., and Williams, K.A. 2007. Stability of housekeeping gene expression in the rat retina during exposure to cyclic hyperoxia. Molecular Vision. 13: 1508-1515.
  47. Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., and Speleman, F. 2002. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology. 3(7): RESEARCH0034.
  48. Wang, A.L., Lukas, T.J., Yuan, M., Du, N., Tso, M.O., and Neufeld, A.H. 2009. Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. PLoS ONE. 4: E4160.
  49. Wei, Y., Gong, J., Yoshida, T., Eberhart, C.G., Xu, Z., Kombairaju, P., Sporn, M.B., Handa, J.T., and Duh, E.J. 2011. Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury. Free Radical Biology and Medicine. 51: 216-224.
  50. Wiegand, R.D., Giusto, N.M., Rapp, L.M., and Anderson, R.E. 1983. Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina. Investigative Ophthalmology & Visual Science. 24: 1433-1435.
  51. Wilkerson, M.K., Colleran, P.N., and Delp, M.D. 2002. Acute and chronic head-down tail suspension diminishes cerebral perfusion in rats. American Journal of Physiology - Heart and Circulatory Physiology. 282: 328-334.
  52. Wise, K.C., Manna, S.K., Yamauchi, K., Ramesh, V., Wilson, B.L., Thomas, R.L., Sarkar, S., Kulkarni, A.D., Pellis, N.R., and Ramesh, G.T. 2005. Activation of nuclear transcription factor-kappaB in mouse brain induced by a simulated microgravity environment. In Vitro Cellular & Developmental Biology - Animal. 41: 118-123.
  53. Yang, D., Elner, S.G., Chen, X., Field, M.G., Petty, H.R., and Elner, V.M. 2011. MCP-1-activated monocytes induce apoptosis in human retinal pigment epithelium. Investigative Ophthalmology & Visual Science. 52: 6026-6034.
  54. Zhu, Y., Zhang, Y., Ojwang, B.A., Brantley, M.A., and Gidday, J.M. 2007. Long-term tolerance to retinal ischemia by repetitive hypoxic preconditioning: role of HIF-1alpha and heme oxygenase-1. Investigative Ophthalmology & Visual Science. 48: 1735-1743.
Language: English
Page range: 29 - 46
Published on: Jul 1, 2013
Published by: American Society for Gravitational and Space Research
In partnership with: Paradigm Publishing Services
Publication frequency: 2 times per year

© 2013 Susana B. Zanello, Corey A. Theriot, Claudia Maria Prospero Ponce, Patricia Chevez-Barrios, published by American Society for Gravitational and Space Research
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.