Selective Inhibitory Effect of Cannabidiol from Cannabis Sp. Plants on Tumour Cell Proliferation
References
- 1. Ibeas Bih, C., Chen, T., Nunn, A. V. W., Bazelot, M., Dallas, M., Whalley, B. J., 2015: Molecular targets of cannabidiol in neurological disorders. Neurotherapeutics, 12, 4, 699–730. DOI: 10.1007/s13311-015-0377-3
- 2. Fraguas-Sánchez, A. I., Martín-Sabroso, C., Torres-Suárez, A. I., 2018: Insights into the effects of the endocannabinoid system in cancer: A review. Br. J. Pharmacol., 175, 13, 2566–2580. DOI: 10.1111/bph.14331
- 3. Hinz, B., Ramer, R., 2019: Anti-tumour actions of cannabinoids. Br. J. Pharmacol., 176, 10, 1384–1394. DOI: 10.1111/bph.14426
- 4. Ligresti, A., Moriello, A. S., Starowicz, K., Matias, I., Pisanti, S., De Petrocellis, L., et al., 2006: Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J. Pharmacol. Exp. Ther., 318, 3, 1375–1387. DOI: 10.1124/jpet.106.105247
- 5. Sultan, A. S., Marie, M. A., Sheweita, S. A., 2018: Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast, 41, 34–41. DOI: 10.1016/j. breast.2018.06.009
- 6. McAllister, S. D., Murase, R., Christian, R. T., Lau, D., Zielinski, A. J., Allison, J., et al., 2011: Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis. Breast Cancer Res. Treat., 129, 1, 37–47. DOI: 10.1007/s10549-010-1177-4
- 7. Scott, K. A., Dalgleish, A. G., Liu, W. M., 2017: Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration. Int. J. Oncol., 51, 1, 369–377. DOI: 10.3892/ijo.2017.4022
- 8. Çifçi, K. U., Çelik, A. B., Güçlü, E., Şahinoğlu, N., Gülüm, L., Çapkınoğlu, E., Tutar, Y: 2026: The effect of cannabidiol on cancer-pathway genes in doxorubicin-sensitive and resistant breast cancer cells. Pharmaceuticals, 19, 4, 615. DOI: 10.3390/ph19040615
- 9. Almeida, C. F., Correia-da-Silva, G., Ribeiro, A. P., Teixeira, N., Amaral, C., 2025: Impact of minor cannabinoids on key pharmacological targets of estrogen receptor-positive breast cancer. Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1870, 6, 159658. DOI: 10.1016/j.bbalip.2025.159658
- 10. Almeida, C. F., Teixeira, N., Correia-da-Silva, G., Amaral, C., 2022: Cannabinoids in breast cancer: Differential susceptibility according to subtype. Molecules, 27, 1, 156. DOI: 10.3390/molecules27010156
- 11. Ma, L., Liu, M., Liu, C., Zhang, H., Yang, S., An, J., et al., 2024: Research progress on the mechanism of the antitumor effects of cannabidiol. Molecules, 29, 9, 1943. DOI: 10.3390/molecules29091943
- 12. Klumpers, L. E., Thacker, D. L., 2019: A brief background on cannabis: From plant to medical indications. J. AOAC Int., 102, 2, 412–420. DOI: 10.5740/jaoacint.18-0208
- 13. Alves, P., Amaral, C., Teixeira, N., Correia-da-Silva, G., 2020: Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol. Pharmacol. Res., 157, 104822. DOI: 10.1016/j. phrs.2020.104822
- 14. Śledziński, P., Zeyland, J., Słomski, R., Nowak, A., 2018: The current state and future perspectives of cannabinoids in cancer biology. Cancer Med., 7, 3, 765–775. DOI: 10.1002/cam4.1312
- 15. Go, Y. Y., Kim, S. R., Kim, D. Y., Chae, S.-W., Song, J.-J., 2020: Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci. Rep., 10, 1, 20622. DOI: 10.1038/s41598-020-77674-y
Language: English
Page range: 69 - 75
Submitted on: Jun 24, 2026
Accepted on: Aug 31, 2026
Published on: Sep 30, 2026
Published by: The University of Veterinary Medicine and Pharmacy in Košice
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Related subjects:
© 2026 Dana Marcinčáková, Mária Kolesárová, Natália Nosálová, Nikola Hudáková, Daša Čížková, Jaroslav Legáth, published by The University of Veterinary Medicine and Pharmacy in Košice
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.