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Toxicological Assessment of Lagenaria breviflora Whole Fruit Extract in Juvenile African Catfish (Clarias gariepinus) Cover

Toxicological Assessment of Lagenaria breviflora Whole Fruit Extract in Juvenile African Catfish (Clarias gariepinus)

Open Access
|Mar 2026

References

  1. 1. Rossignoli, C. M., Manyise, T., Shikuku, K. M., Nasr-Allah, A. M., Dompreh, E. B., Henriksson, P. J., Gasparatos, A., 2023: Tilapia aquaculture systems in Egypt: Characteristics, sustainability outcomes and entry points for sustainable aquatic food systems. Aquaculture, 577, 739952. DOI: 10.1016/j.aquaculture.2023.739952
  2. 2. Dienye, H. E., Olopade, O. A., Obi, C. O., 2021: Socio-Economic and Cost Benefits of Catfish (Clarias gariepinus) Marketing in Obio-Akpor Local Government Area, Rivers State, Nigeria. J. Limnol. Freshw. Fish. Res., 7, 40–48.
  3. 3. Dauda, A. B., Romano, N., Ebrahimi, M., Teh, J. C., Ajadi, A., Chong, C. M., et al., 2018: Influence of carbon/nitrogen ratios on biofloc production and biochemical composition and subsequent effects on the growth, physiological status and disease resistance of African catfish (Clarias gariepinus) cultured in glycerol-based biofloc systems. Aquaculture, 483, 120–130. DOI: 10.1016/j.aquaculture.2017.10.016
  4. 4. Ogunji, J., Wuertz, S., 2023: Aquaculture development in Nigeria: The second biggest aquaculture producer in Africa. Water, 15, 24, 4224. DOI: 10.3390/w15244224
  5. 5. Mugwanya, M., Dawood, M. A. O., Kimera, F., Sewilam, H. 2022: Anthropogenic temperature fluctuations and their effect on aquaculture: A comprehensive review. Aquaculture and Fisheries, 7, 3, 223–243. DOI: 10.1016/j. aaf.2021.12.005
  6. 6. Anifowose, O. R, Oladosu, G. A, Oladele, O. O., 2021: Causal factors of mass mortality of hatchery-reared Clarias gariepinus fry during exogenous feeding. Int. J. Fish. Aquat. Stud., 9, 1, 235–239. DOI: 10.22271/fish.2021.v9.i1c.2409
  7. 7. Anifowose, O. R., Oladosu, G. A., Oladele, O. O., 2022: Comparative growth performance and survival of hatch-ery-reared African catfish fry (Clarias gariepinus Burchell 1822) fed on live and artificial diets. Int. J. Fish. Aquat. Stud., 10, 2, 106–112. DOI: 10.22271/fish.2022.v10.i2b.2647
  8. 8. Zhu, F., 2020: A review on the application of herbal medicines in the disease control of aquatic animals. Aquaculture, 526, 735422. DOI: 10.1016/j.aquaculture.2020.735422
  9. 9. Gariya, H. S., Bhatt, A., 2021: Microbial Action on Degradation of Pesticides. Microbial Technology for Sustainable Environment, 125–139.
  10. 10. Hossain, M., Islam, T., Jalil, M. A., Rakibuzzaman, S., Surid, S. M., Zabed, R. I., et al., 2024: Advancements of eco‐friendly natural antimicrobial agents and their transformative role in sustainable textiles. SPE Polymers, 5, 3, 241–276. DOI: 10.1002/pls2.10135
  11. 11. Tadese, D. A., Song, C., Sun, C., Liu, B., Liu, B., Zhou, Q., et al., 2022: The role of currently used medicinal plants in aquaculture and their action mechanisms: A review. Rev. Aquac., 14, 2, 816–847. DOI: 10.1111/raq.12626
  12. 12. Oridupa, O., Omobowale, T. O., Oyagbemi, A. A., Danjuma, N. O., Obisesan, A. D., Olakojo, T. A., Saba, A. B., 2023: Antioxidant activity enhancement and oxidative damage inhibition by Lagenaria breviflora fruit and Xanthosoma sagittifolium corm in hypertensive Wistar rats. Niger. J. Physiol. Sci., 38, 1, 101–106. DOI: 10.54548/njps.v38i1.14
  13. 13. Tomori, O. A., Saba, A. B., Dada-Adegbola, H. O., 2007: Antibacterial activity of ethanolic extract of whole fruit of Lagenaria breviflora Roberts. J. Anim. Vet. Adv., 6, 5, 752–757.
  14. 14. Paray, B. A., Adeshina, I., Bhat, E. A., Raji, A., Umma, S. B., Alliy, R. O., Tiamiyu, L. O., 2024: Effect of dietary Lagnaria breviflora leaves extract on the growth performance, haematological, antioxidative and immune responses of African catfish (Clarias gariepinus) juveniles. J. Anim. Physiol. Anim. Nutr., 108, 4, 1164–1175.DOI: 10.1111/jpn.13962
  15. 15. Olorunnisola, O. S., Afolayan, A. J., Adetutu, A., 2015: Sub-chronic administration of methanolic whole fruit extract of Lagenaria breviflora (Benth.) Roberty induces mild toxicity in rats. Pharmacogn. Mag., 11, 44, (Suppl 4), S516–21. DOI: 10.4103/0973-1296.172955
  16. 16. Adeshina, I., Emikpe, B. O., Jenyo-Oni, A., Ajani, E. K., Abubakar, M. I., 2020: Haematology, plasma biochemistry and serum of table size African catfish, Clarias gariepinus, naturally infected with Listeria species in Oyo State. Comp. Clin. Pathol., 29, 69–73.
  17. 17. Roberts, R. J., 2004: Fish Pathology. 3rd ed., W.B. Saunders, USA
  18. 18. Mohammed, S. G., Mousa, A. H. M., Hashim, A. M., 2020: Role of hypochromia and microcytosis in the prediction of iron deficiency anemia. Minia Journal of Medical Research, 31, 3, 262–268.
  19. 19. Senthil Kumaran, S., Kavitha, C., Ramesh, M., Grummt, T., 2011: Toxicity studies of nonylphenol and octylphenol: hormonal, hematological and biochemical effects in Clarias gariepinus. J. Appl. Toxicol., 31, 8, 752–761. DOI: 10.1002/jat.1629
  20. 20. Tauheed, A. M., Mamman, M., Ahmed, A., Sani, N. I. A., Suleiman, M. M., Sulaiman, M. H., Balogun, E. O., 2021: Acute, sub-acute, sub-chronic and chronic toxicity studies of four important Nigerian ethnomedicinal plants in rats. Clin. Phytosci., 7, 1, 1–12.
  21. 21. Tort, L., 2011: Stress and immune modulation in fish. Dev. Comp. Immunol., 35, 12, 1366–1375. DOI: 10.1016/j. dci.2011.07.002
  22. 22. Ezhilarasan, D., 2018: Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective. Arab J. Gastroenterol., 19, 2, 56–64. DOI: 10.1016/j.ajg.2018.03.002
  23. 23. Adeogun, A. O., Alaka, O. O., Taiwo, V. O., Fagade, S. O., 2012: Some pathological effects of sub-lethal concentrations of the methanolic extracts of Raphia hookeri on Clarias gariepinus. Afr. J. Biomed. Res., 15, 2, 105–115.
  24. 24. Wood, C. M., 2017: Toxic responses of the gill. In Target organ toxicity in marine and freshwater teleosts, CRC Press, pp. 1–89.
  25. 25. Chandel, M., Sharma, A. K., Thakur, K., Sharma, D., Brar, B., Mahajan, D., et al., 2024: Poison in the water: Arsenic’s silent assault on fish health. J. Appl. Toxicol., 44, 9, 1282–1301. DOI: 10.1002/jat.4581
DOI: https://doi.org/10.2478/fv-2026-0006 | Journal eISSN: 2453-7837 | Journal ISSN: 0015-5748
Language: English
Page range: 56 - 66
Submitted on: Aug 15, 2025
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Accepted on: Dec 15, 2025
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Published on: Mar 21, 2026
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2026 Olayinka Remilekun Anifowose, Solomon Ayomide Ogunyemi, Tolulope Ademola Olakojo, Bisi Olajumoke Adeoye, Gbolahanmi Akinola Oladosu, Olayinka Ayotunde Oridupa, published by The University of Veterinary Medicine and Pharmacy in Košice
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.