Comparative pharmacokinetics of intravenous and intramuscular meloxicam in Awassi sheep: Implications for extended therapeutic efficacy
References
- 1. Mathews, K. A., 2002: Non ‐steroidal anti ‐inflammatory analgesics: a review of current practice. J. Vet. Emerg. Crit. Care, 12, 2, 89–97. DOI: 10.1046/j.1435-6935.2002.00007.x
- 2. Bae, J.-W., Kim, M.-J., Jang, C.-G., Lee, S.-Y., 2007: Determination of meloxicam in human plasma using a HPLC method with UV detection and its application to a pharmacokinetic study. J. Chromatogr. B, 859, 1, 69–73. DOI: 10.1016/j.jchromb.2007.09.004
- 3. Toutain, P.-L., Reymond, N., Laroute, V., Garcia, P., Popot, M.-A., Bonnaire, Y., Hirsch, A., Narbe, R., 2004: Pharmacokinetics of meloxicam in plasma and urine of horses. Am. J. Vet. Res., 65, 11, 1542–1547. DOI: 10.2460/ajvr.2004.65.1542
- 4. Coetzee, J. F., KuKanich, B., Mosher, R., Allen, P. S., 2009: Pharmacokinetics of intravenous and oral meloxicam in ruminant calves. Vet. Ther., 10, 4, E1–E8.
- 5. Warner, R., Ydstie, J., Wulf, L. W., Gehring, R., Coetzee, J. F., Mochel, J. P., Gorden, P. J., 2020: Comparative pharmacokinetics of meloxicam between healthy post-partum vs. mid-lactation dairy cattle. Front. Vet. Sci., 7, 3, 548. DOI: 10.3389/fvets.2020.00548
- 6. Lin, H., 2022: Pain management for farm animals. Farm Anim. Anesth. Cattle, Small Ruminants, Camelids, Pigs, 21, 207–246. DOI: 10.1002/9781119672661.ch10
- 7. Toutain, P.-L., Ferran, A., Bousquet-Mélou, A., 2010: Species differences in pharmacokinetics and pharmacodynamics. Comp. Vet. Pharmacol., 19–48. DOI: 10.1007/978-3-642-10324-7_2
- 8. Shukla, M., Singh, G., Sindhura, B. G., Telang, A. G., Rao, G. S., Malik, J. K., 2007: Comparative plasma pharmacokinetics of meloxicam in sheep and goats following intravenous administration. Comp. Biochem. Physiol. Part C Toxicol. Pharmacol., 145, 4, 528–532. DOI: 10.1016/j. cbpc.2007.01.020
- 9. Stock, M. L., Coetzee, J. F., KuKanich, B., Smith, B. I., 2013: Pharmacokinetics of intravenously and orally administered meloxicam in sheep. Am. J. Vet. Res., 74, 5, 779–783. DOI: 10.2460/ajvr.74.5.779
- 10. Woodland, A. N., Van der Saag, D., Kimble, B., White, P. J., Govendir, M., Lomax, S., 2019: Plasma pharmaco-kinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep. PLoS One, 14, 4, e0215842. DOI: 10.1371/journal.pone.0215842
- 11. Zhang, Y., Huo, M., Zhou, J., Xie, S., 2010: PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel. Comput. Methods Programs Biomed., 99, 3, 306–314. DOI: 10.1016/j.cmpb.2010.01.007
- 12. Depenbrock, S., Urbano, T., Ziegler, J., Wetzlich, S., Clapham, M. O., Tell, L. A., 2021: Pharmacokinetic parameters and tissue withdrawal intervals for sheep administered multiple oral doses of meloxicam. Animals, 11, 10, 2797. DOI: 10.3390/ani11102797
- 13. Baert, K., De Backer, P., 2003: Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species. Comp. Biochem. Physiol. Part C Toxicol. Pharmacol., 134, 1, 25–33. DOI: 10.1016/S1532-0456(02)00184-9
Language: English
Page range: 73 - 78
Submitted on: Jul 30, 2025
Accepted on: Oct 11, 2025
Published on: Dec 23, 2025
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Related subjects:
© 2025 Nagham Mahmoud Abdelqader, Ahmed Thayer Mohammed, Yasser Mohammed Amin Albadrany, published by The University of Veterinary Medicine and Pharmacy in Košice
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.