Have a personal or library account? Click to login
Concentrations of some heavy and trace metals in serum and brain of five species of wild vertebrates from Nigeria Cover

Concentrations of some heavy and trace metals in serum and brain of five species of wild vertebrates from Nigeria

Open Access
|Jun 2025

References

  1. 1. Ghorani-Azam, A., Riahi-Zanjani, B., Balali-Mood, M., 2016: Effects of air pollution on human health and practical measures for prevention in Iran. J. Res. Med. Sci., 21, 1, 65. DOI: 10.4103/1735-1995.189646
  2. 2. Luo, L., Wang, B., Jiang, J., Fitzgerald, M., Huang, Q., Yu, Z., et al., 2021: Heavy metal contaminations in herbal medicines: determination, comprehensive risk assessments, and solutions. Front. Pharmacol., 11. DOI: 10.3389/fphar.2020.595335
  3. 3. Tchounwou, P. B, Yedjou, C. G., Patlolla, A. K., Sutton, D. J., 2012: Heavy metal toxicity and the environment, EXS, 101, 133–164. DOI: 10.1007/978-3-7643-8340-4_6
  4. 4. Fukada, T., Kambe, T., 2011: Molecular and genetic features of zinc transporters in physiology and pathogenesis. Metallomics, 3, 7, 662–674. DOI: 10.1039/c1mt00011j
  5. 5. Femi-Akinlosotu, O. M., Olopade, F. E., Obiako, J., Olopade, J.O., Shokunbi, M. T., 2023: Vanadium improves memory and spatial learning and protects the pyramidal cells of the hippocampus in juvenile hydrocephalic mice. Front. Neurol., 14. DOI: 10.3389/fneur.2023.1116727
  6. 6. Mehri, A., 2020: Trace elements in human nutrition (II) -an update. Int. J. Prev. Med., 11, 1, 2. DOI: 10.4103/ijpvm. IJPVM_48_19
  7. 7. Ramos, P., Santos, A., Pinto, N. R., Mendes, R., Magalhães, T., Almeida, A., 2014: Anatomical region differences and age-related changes in copper, zinc, and manganese levels in the human brain. Biol. Trace. Elem. Res., 161, 190–201. DOI: 10.1007/s12011-014-0093-6
  8. 8. Kardos, J., Héja, L., Simon, Á., Jablonkai, I., Kovács, R., Jemnitz, K., 2018: Copper signalling: causes and consequences. Cell Commun. Signal., 16, 71. DOI: 10.1186/s12964-018-0277-3
  9. 9. Georgieff, M. K., 2008: The role of iron in neurodevelopment: fetal iron deficiency and the developing hippocampus. Biochem. Soc. Trans., 36, 6, 1267–1271. DOI: 10.1042/BST0361267
  10. 10. Ijomone, O. M., Ifenatuoha, C. W., Aluko, O. M., Ijomone, O. K., Aschner, M., 2020: The aging brain: impact of heavy metal neurotoxicity. Crit. Rev. Toxicol., 50, 9, 801–814. DOI: 10.1080/10408444.2020.1838441
  11. 11. Jadhav, S. H., Sarkar, S. N., Patil, R. D., Tripathi, H. C., 2007: Effects of subchronic exposure via drinking water to a mixture of eight water-contaminating metals: A biochemical and histopathological study in male rats. Arch. Environ. Contam. Toxicol., 53, 667–677. DOI: 10.1007/s00244-007-0031-0
  12. 12. Usende, I. L., Alimba, C. G., Emikpe, B. O., Bakare, A. A., Olopade, J. O., 2018: Intraperitoneal sodium metavana-date exposure induced severe clinicopathological alterations, hepato-renal toxicity and cytogenotoxicity in African giant rats (Cricetomys gambianus, Waterhouse, 1840). Environ. Sci. Pollut. Res., 25, 26383–26393. DOI: 10.1007/s11356-018-2588-8
  13. 13. Deng, Y., Wang, M., Tian, T., Lin, S., Xu, P., Zhou, L., et al., 2019: The Effect of hexavalent chromium on the incidence and mortality of human cancers: A meta-analysis based on published epidemiological cohort studies. Front. Oncol., 9, 24. DOI: 10.3389/fonc.2019.00024
  14. 14. Clancy, H. A., Sun, H., Passantino, L., Kluz, T., Muñoz, A., Zavadil, J., et al., 2012: Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics, 2012, 4, 8, 784–793. DOI: 10.1039/c2mt20074k
  15. 15. Koedrith, P., Kim, H., Weon, J. I., Seo, Y. R., 2013: Toxicogenomic approaches for understanding molecular mechanisms of heavy metal mutagenicity and carcinogenicity. Int. J. Hyg. Environ. Health., 216, 5, 587–598. DOI: 10.1016/j. ijheh.2013.02.010
  16. 16. Milam, C., Buba, M., Dogara, R. K., Yila, E. Y., 2017: Assessment of heavy metals (As, Cd, Cr, Cu, Ni, Pb and Zn) in blood samples of sheep and rabbits Jimeta-Yola, Adamawa State, Nigeria. IJAPBC, 6, 3, 2277–4688.
  17. 17. Jubril, A. J., Kabiru, M., Olopade, J. O., Taiwo, V. O., 2017: Biological monitoring of heavy metals in goats exposed to environmental contamination in Bagega, Zamfara State, Nigeria. Adv. Environ. Biol., 11, 6, 11–18.
  18. 18. Jubril, A. J., Obasa, A. A., Mohammed, S. A., Olopade, J. O., Taiwo, V. O., 2019: Neuropathological lesions in the brains of goats In North-Western Nigeria: possible impact of artisanal mining. Environ. Sci. Pollut. Res. Int., 26, 36, 36589–36597. DOI: 10.1007/s11356-019-06611-y
  19. 19. Hammond, P. B., Aronson, A. L., 1964: Lead poisoning in cattle and horses in the vicinity of a smelter. Ann. N. Y. Acad. Sci., 111, 2, 595-611. DOI: 10.1111/j.1749-6632.1964.tb53128.x
  20. 20. Tsuchiya, K., 1992: The discovery of the causal agent of Minamata disease. Am. J. Ind. Med., 21, 2, 275-280.
  21. 21. Roelofs, P., 2021: Urban renewal in Ibadan, Nigeria: World class but essentially Yoruba, African Affairs, 120, 480, 391–415. DOI: 10.1093/afraf/adab021
  22. 22. Olopade, J. O., Mustapha, O. A., Fatola, O. I., Ighorodje, E., Folarin, O. R., Olopade, F. E., et al., 2023: Neuropatho-logical profile of the African Giant Rat brain (Cricetomys gambianus) after natural exposure to heavy metal environmental pollution in the Nigerian Niger Delta. Environ. Sci. Pollut. Res., 30, 120496–120514. https://doi.org/10.1007/s11356-023-30619-0
  23. 23. Igado, O. O., Andrioli, A., Azeez, I. A., Girolamo, F., Errede, M., Aina, O. O., et al., 2020: The ameliorative effects of a phenolic derivative of Moringa oleifera leave against vanadium-induced neurotoxicity in mice. IBRO Reports, 9, 164–182. DOI: 10.1016/j.ibror.2020.07.004
  24. 24. Perkin-Elmer, 1996: Analytical Methods for Atomic Absorption Spectroscopy. Perkin-Elmer Corporation, USA
  25. 25. Khazaeli, S., Nezamabadi, N., Rabani, M., Panahi, H. A., 2013: A new functionalized resin and its application in flame atomic absorption spectrophotometric determination of trace amounts of heavy metal ions after solid phase extraction in water samples. Microchem. J., 106, 147–153. DOI: 10.1016/j.microc.2012.06.002
  26. 26. Hernández-Plata, I., Rodríguez, V. M., Tovar-Sánchez, E., Carrizalez, L., Villalobos, P., Mendoza-Trejo, M. S., et al., 2020: Metal brain bioaccumulation and neurobehavioral effects on the wild rodent (Liomys irroratus) inhabiting mine tailing areas. Environ. Sci. Pollut. Res., 27, 29, 36330–36349. DOI: 10.1007/s11356-020-09451-3
  27. 27. Morais, S., Costa, F. G., Pereira, M. L., 2012: Heavy metals and human health, In Environmental health – emerging issues and practice. InTech. DOI: 10.5772/29869
  28. 28. Gall, J. E., Boyd, R. S., Rajakaruna, N., 2015: Transfer of heavy metals through terrestrial food webs: a review. Environ. Monit. Assess., 187, 201. DOI: 10.1007/s10661-015-4436-3
  29. 29. Basu, N., Scheuhammer, A. M., Sonne, C., Letcher, R. J., Born, E. W., Dietz, R. 2009: Is dietary mercury of neurotoxicological concern to wild polar bears (Ursus maritimus)? Environ. Toxicol. Chem., 28, 1, 133–140. DOI: 10.1897/08-251.1
  30. 30. Krey, A., Kwan, M., Chan, H. M., 2014: In vivo and in vitro changes in neurochemical parameters related to mercury concentrations from specific brain regions of polar bears (Ursus maritimus). Environ. Toxicol. Chem., 33, 11, 2463–2471. DOI: 10.1002/etc.2685
  31. 31. Krey, A., Ostertag, S. K., Chan, H. M., 2015: Assessment of neurotoxic effects of mercury in beluga whales (Delphi-napterus leucas), ringed seals (Pusa hispida), and polar bears (Ursus maritimus) from the Canadian Arctic. Sci. Total. Env., 509–510, 237–247. DOI: 10.1016/j.scitotenv.2014.05.134
  32. 32. Ostertag, S. K., Shaw, A. C., Basu, N., Chan, H. M., 2014: Molecular and neurochemical biomarkers in Arctic beluga whales (Delphinapterus leucas) were correlated to brain mercury and selenium concentrations. Env. Sci. Technol., 48, 19, 11551–11559. DOI: 10.1021/es501369b
  33. 33. Meador, J. P., Ernest, D., Hohn, A. A., Tilbury, K., Gorzelany, J., Worthy, G., et al., 1999: Comparison of elements in bottlenose dolphins stranded on the beaches of Texas and Florida in the Gulf of Mexico over a one-year period. Arch. Environ. Contam. Toxicol., 36, 87–98. DOI: 10.1007/s002449900446
  34. 34. Dornbos, P., Strom, S., Basu, N., 2013: Mercury exposure and neurochemical biomarkers in multiple brain regions of Wisconsin River Otters (Lontra canadensis). Ecotoxicology, 22, 469–475. DOI: 10.1007/s10646-013-1040-6
  35. 35. Erry, B. V., Macnair, M. R., Meharg, A. A., Shore, R. F., 2005: The distribution of arsenic in the body tissues of wood mice and bank voles. Arch. Environ. Contam. Toxicol., 49, 569–576. DOI: 10.1007/s00244-004-0229-3
  36. 36. Thomson, C., Hahn, C., Johnson, C., 2012: Veterinary Neuroanatomy: A Clinical Approach. Edinburgh: Saunders/Elsevier, ISBN 9780702034824.
  37. 37. Kim, J. J., Kim, Y. S., Kumar, V. 2019: Heavy metal toxicity: An update of chelating therapeutic strategies. J. Trace Elem. Med. Biol., 54, 226-231. DOI: 10.1016/j. jtemb.2019.05.003
  38. 38. Kalisińska, E., Salicki, W., Mysłek, P., Kavetska, K. M., Jackowski, A., 2004: Using the mallard to biomonitor heavy metal contamination of wetlands in north-western Poland. Sci. Total. Environ., 320, 2-3, 145–161. DOI: 10.1016/j.scitotenv.2003.08.014
  39. 39. Kalisinska, E., Lanocha-Arendarczyk, N., Kosik-Bogacka, D., Budis, H., Podlasinska, J., Popiolek, M., et al., 2016. Brains of native and alien mesocarnivores in biomonitoring of toxic metals in Europe. PLoS One, 11, 8, 1–27. DOI: 10.1371/journal.pone.0159935
  40. 40. Cid, F. D., Gatica-Sosa, C., Anton, R. I., Caviedes-Vidal, E., 2009: Contamination of heavy metals in birds from Embalse La Florida (San Luis, Argentina). J. Environ. Monit., 11, 2044–2051. DOI: 10.1039/b906227k
  41. 41. Lindsay, D., Kerr, W., 2011: Cobalt close-up. Nat. Chem., 3, 494. DOI: 10.1038/nchem.1053
  42. 42. Jumba, I. O., Kisia, S. M., Kock, R., 2007: Animal health problems attributed to environmental contamination in Lake Nakuru National Park, Kenya: A case study on heavy metal poisoning in the Waterbuck Kobus ellipsiprymnus defassa (Ruppel, 1835). Arch. Environ. Contam. Toxicol., 52, 270–281. DOI: 10.1007/s00244-005-0241-2
  43. 43. Jaishankar, M., Tseten, T., Anbalagan, N., Mathew, B. B., Beeregowda, K. N., 2014: Toxicity, mechanism and health effects of some heavy metals. Interdiscip. Toxicol., 7, 2, 60–72. DOI: 10.2478/intox-2014-0009
  44. 44. Agency for Toxic Substances and Disease Registry, USA. https://www.atsdr.cdc.gov/toxicological-profiles/glossary/index.html#heading-c. Accessed May 25, 2025.
  45. 45. Maľová, J., Ciberej, J., Maľa, P., Zigo, F., Semjon, B., 2019: Heavy metal levels in the tissues of wild living animals from two distinct industrially exploited areas in Slovakia. Slovak J. Anim. Sci., 52, 3, 100–110.
  46. 46. Aloupi, M., Karagianni, A., Kazantzidis, S., Akriotis, T., 2017: Heavy metals in liver and brain of waterfowl from the Evros Delta, Greece. Arch. Environ. Contam. Toxicol., 72, 215–234. DOI: 10.1007/s00244-016-0349-6
  47. 47. Lambert, M., Leven, B. A., Green, R. M., 2000: New methods of cleaning up heavy metal in soils and water. Environmental Science and Technology Briefs for Citizens.
  48. 48. Kumar, V., Kalita, J., Misra, U. K., Bora, H. K., 2015: A study of dose response and organ susceptibility of copper toxicity in a rat model. J. Trace Elem. Med. Biol., 29, 269–274. DOI: 10.1016/j.jtemb.2014.06.004
  49. 49. Aaseth, J., Crisponi, G., Andersen, O., 2016: Chelation therapy in the treatment of metal intoxication, 1st edition, Academic Press.
  50. 50. Igado, O. O., Olopade, J. O., Onwuka, S. K., Onwuka, A. C, Daramola, O. A, Ajufo, U. E., 2008: Evidence of environmental pollution in caprine brains obtained from a relatively unindustrialized area in Nigeria. African J. Biomed. Res., 11, 3, 305–309. DOI: 10.4314/ajbr.v11i3.50744
  51. 51. Valko, M., Morris, H., Cronin, M. T. D., 2005: Metals, toxicity and oxidative stress. Curr. Med. Chem., 12, 10, 1161–1208. DOI: 10.2174/0929867053764635
  52. 52. Kalisińska, E., 2000: Lead and other heavy metals in the brain of geese hunted in the vicinity of Slonsk, Poland. Biol. Bull. Poznań, 37, 2, 273–286.
  53. 53. Havera, S. P., Wood, S. G., Georgi, M. M., 1992: Blood and tissue parameters in wild mallards redosed with lead shot. Bull. Environ. Contam. Toxicol., 49, 238–245.
  54. 54. Stout, J. D., Brinker, D. F., Driscoll, C. P., Davison, S., Murphy, L. A., 2010: Serum biochemistry values, plasma mineral levels, and whole blood heavy metal measurements in wild Northern goshawks (Accipiter gentilis). J. Zoo. Wildl. Med., 41, 4, 649–655. DOI: 10.1638/2009-0258.1
  55. 55. de Carvalho, F. M., Gaunt, S. D., Kearney, M. T., Rich, G. A., Tully, T. N. Jr., 2009: Reference intervals of plasma calcium, phosphorus, and magnesium for African grey parrots (Psittacus erithacus) and Hispaniolan parrots (Amazona ventralis). J. Zoo. Wildl. Med., 40, 4, 675–679. DOI: 10.1638/2009-0012.1
  56. 56. Tarale, P., Chakrabarti, T., Sivanesan, S., Naoghare, P., Bafana, A., Krishnamurthi, K., 2016: Potential role of epigenetic mechanism in manganese induced neurotoxicity. Biomed. Res. Int., 2016, 2548792. DOI: 10.1155/2016/2548792
  57. 57. Tomza-Marciniak, A., Pilarczyk, B., Bąkowska, M., Ligocki, M., Gaik, M., 2012: Lead, cadmium and other metals in serum of pet dogs from an urban area of NW Poland. Biol. Trace Elem. Res., 149, 345-51. DOI: 10.1007/s12011-012-9433-6
  58. 58. Nam, D. H., Rutkiewicz, J., Basu, N., 2012: Multiple metals exposure and neurotoxic risk in bald eagles (Haliaeetus leucocephalus) from two Great Lakes states. Environ. Toxicol. Chem., 31, 3, 623–631. DOI: 10.1002/etc.1712
DOI: https://doi.org/10.2478/fv-2025-0018 | Journal eISSN: 2453-7837 | Journal ISSN: 0015-5748
Language: English
Page range: 56 - 71
Submitted on: Apr 26, 2025
Accepted on: May 26, 2025
Published on: Jun 25, 2025
Published by: The University of Veterinary Medicine and Pharmacy in Košice
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Olumayowa Olawumi Igado, Funmilayo Eniola Olopade, Taidinda Tashara Gilbert, Adedunsola Adewunmi Obasa, Irene Chizubelu Omile, Iheanyi Kemdirim Peter-Ajuzie, Kehinde Iyanuoluwa Adedokun, James Olukayode Olopade, published by The University of Veterinary Medicine and Pharmacy in Košice
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.