Have a personal or library account? Click to login
The Significance of Monitoring Serum and Faecal Calprotectin in Healthy Dogs Cover

References

  1. Allenspach, K. A., Wieland, B., Gröne, A., Gaschen, F., 2007: Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. J. Vet. Intern. Med., 21, 4, 700‒708. DOI: 10.1892/0891- 6640(2007)21[700:ceideo]2.0.co;2.
  2. Allenspach, K. A., 2015: Diagnosis of small intestinal disorders in dogs and cats. Clin. Lab. Med., 35, 521‒534. DOI: 10.1016/j.cell.2015.05.003.
  3. Allenspach, K., Culverwell, C., Chan, D., 2016: Long-term outcome in dogs with chronic enteropathies: 203 cases, Vet. Rec., 178, 15, 362‒368. DOI: 10.1136/vr.103557.
  4. Allenspach, K. A., Mochel, J. P., Du, Y., Preistnall, S. L., Moore, F., Slayter, M., et al., 2019: Correlation gastrointestinal histopathologic changes to clinical disease activity in dogs with idiopathic inflammatory bowel disease. Vet. Pathol., 56, 3, 435‒443. DOI: 10.1177/0300985818813090
  5. Allenspach, K. A., Mochel, J. P., 2022: Current diagnostics for chronic enteropathies in dogs. Vet. Clin. Pathol., 50, Suppl. 1, 18‒28. DOI: 10.1111/vcp. 13068.
  6. Cerqutella, M., Spaterna, A., Laus, F., Tesei, B., Rossi, G., Antonelli, E., et al., 2010: Inflammatory bowel disease in the dog: Diferences and similarities with humans. World J. Gastroenterol., 16, 9, 1050‒1056. DOI: 10.3748/wjg.v16.i9.1050.
  7. Dandrieux, J. R. S., 2016: Inflammatory bowel disease versus chronic enteropathy in dogs: Are they one and the same? J. Small Anim. Pract., 57, 589‒599. DOI: 10.1111/ jsap.12588.
  8. Dandrieux, J. R. S., Mansfield, C. S., 2019: Chronic enteropathy. In Canines: Prevalence, impact and management strategies. Vet. Med. Res. Rep., 10, 203‒214. DOI: 10.2147/ VMRR.S162774.
  9. Day, M. J., Bilzer, T., Mansell, J., Wilcock, B., Hall, E. J., Jergens, A., et al., 2008: Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: A report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group. J. Comp. Pathol., 138, S1, 43. DOI: 10.1016/j.jcpa.2008.01.001.
  10. Dupouy-Manescau, N., Méric, T., Sénécat, O., Drut, A., Valentin, S., Oliveira, R. L., Hernandez, J., 2024: Updating the classification of chronic inflammatory enteropathies in dogs. Animals, 14, 681. DOI: 10.3390/ani14050681.
  11. Enderle, L. L., Köller, G., Heilmann, R. M., 2022: Verification of fCAL turboimmunoturbidimetric assay for measurement of faecal calprotectin concentrations in dogs and cats. J. Vet. Diagn. Invest., 34, 5, 813‒824. DOI: 10.1177/10406387221114031.
  12. Estruch, J., Johnson, J., Ford, S., Yoshimoto, S., Mills, T., Bergman, P., 2021: Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs. J. Vet. Intern. Med., 35, 3, 1306‒1315. DOI: 10.1111/jvim.16132.
  13. Garcia-Sancho, M., Rodríguez-Franco, F., Sainz, A., Mancho, C., Rodríguez, A., 2007: Evaluation of clinical, macroscopic, and histopathologic response to treatment in nonhypoproteinemic dogs with lymphocytic-plasmacytic enteritis. J. Vet. Intern. Med., 21, 11‒17. DOI: 10.1892/0891-6640(2007)21[11:eocmah]2.0.co;2.
  14. Geffré, A., Friedrichs, K., Harr, K., Concordet D., Trumel, C., Braun, J. P., 2009: Reference values: A review. Vet. Clin. Pathol., 38, 288‒298. DOI: 10.1111/j.1939-165X.2009.00179.x.
  15. Grellet, A., Heilmann, R. M., Lecoindre, P., Feugier, A., Day, M. J., Peeters, D., et al., 2013: Faecal calprotectin concentrations in adult dogs with chronic diarrhoea. Am. J. Vet. Res., 74, 5, 706‒711. DOI: 10.2460/ajvr.74.5.706.
  16. Grellet, A., Mila, H., Heilmann, R. M., Feugier, A., Gruetzner, N., Suchodolski, J. S., et al., 2014: Effect of age, gestation and lactation on fecal IgA and calprotectin concentrations in dogs. Waltham Supplement, JSN, 3, 1‒5. DOI: 10.1017/jns.2014.44.
  17. Heilmann, R. M., Suchodolski, J. S., Steiner, J. M., 2008: Development and analytic validation of a radioimmunoassay for the quantification of canine calprotectin in serum and feces from dogs. Am. J. Vet. Res., 69, 845‒853. DOI: 10.2460/ ajvr.69.7.845.
  18. Heilmann, R. M., Jergens, A. E., Ackermann, M. R., Barr, J. W., Suchodolski, J. S., Steiner, J. M., 2012: Serum calprotectin concentrations in dogs with idiopathic inflammatory bowel disease. Am. J. Vet. Res., 73, 1900‒1907. DOI: 10.2460/ajvr.73.12.1900.
  19. Heilmann, R. M., Grellet, A., Allenspach, K., Lecoindre, P., Day, M. J., Priestnal, S. L., et al., 2014: Association between faecal S100A12 concentration and histologic, endoscopic, and clinical disease severity in dogs with idiopathic inflammatory bowel disease. Vet. Immunol. Immunopathol., 158, 156‒166. DOI: 10.1016/j.vetimm.2014.01.006.
  20. Heilmann, R. M., Berghoff, N., Mansell, J., Grützner, N., Parnell, N. K., Gurtner, C., et al., 2018: Association of faecal calprotectin concentrations with disease severity, response to treatment, and other biomarkers in dogs with chronic inflammatory enteropathies. J. Vet. Intern. Med., 32, 679‒692. DOI: 10.1111/jvim.15065.
  21. Heilmann, R. M., Steiner, J. M., 2018: Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs. J. Vet. Intern. Med., 32,1495‒1508. DOI: 10.1111/ jvim.15247.
  22. Heilmann, R. H., Ruaux, C. G., Grützner, N., Crand-ford, S. M., Bridges, C. S., Steiner, J. M., 2019: Biological variation of serum canine calprotectin concentrations as measured by ELISA in healthy dogs. Vet. J., 247, 61‒64. DOI: 10.1016/j.tvjl.2019.03.002.
  23. Heilmann, R. M., Nestler, J., Schwarz, J., Grützner, N., Ambrus, A., Seeger, J., et al., 2019: Mucosal expression of S100A12 (calgranulin C) and S100A8/A9 (calprotectin) and corellation with serum and fecal concentrations in dogs with chronic inflammatory enteropathy. Vet. Immunol. Immunopathol., 211, 64‒74. DOI: 10.1016/j.vetimm.2019.04.003.
  24. Heilmann, R. M., Xenoulis, P., Müller, K., Stavroulaki, E. M., Suchodolski, J. S., Steiner, J. M., 2019: Association of serum calprotectin (A100A8/A9) concentrations and idiopathic hyperlipidemia in Miniature Schnauzers. J. Vet. Inter. Med., 1‒10. DOI: 10.1111/jvim.15460.
  25. Hernandez, J., Rouillé, E., Chocteau, F., Allard, M., Haurogné, K., Hervé, J. M., et al., 2021: Nonhypoalbuminemic inflammatory bowel disease in dogs as disease model. Inflam. Bowel Dis., 27, 1975‒1985. DOI: 10.1093/ibd/izab064.
  26. Jergens, A. E., Schneider, C. A., Frank, D. E., 2003: A scoring index for disease activity in canine inflammatory bowel disease. J. Vet. Med., 17, 291‒297. DOI: 10.1111/j.1939-1676.2003.tb02450.x
  27. Jergens, A. E., Heilmann, R. M., 2022: Canine chronic enteropathy-current astate-of-the-art and emerging concepts. Front. Vet. Sci., 9, 923013. DOI: 10.3389/fvets.2022.923013.
  28. Kalenyak, K., Isaiah, A., Heilmann, R. M., Suchodolski, J. S., Burgener, I. A., 2018: Comparison of the intestinal mucosal microbiota in dogs diagnosed with idiopathic inflammatory bowel disease and dogs with food-responsive diarrhoea before and after treatment. FEMS Microbiol. Ecol., 94, 2, 1‒11. DOI: 10.1093/femsec/fix173.
  29. Kathrani, A., Werling, D., Allenspach, K., 2011: Canine breeds at high risk of developing inflammatory bowel disease in the south-eastern area UK. Vet. Rec., 10, 169, 635. DOI: 10.1136/vr.d5380.
  30. Kobayashi, S., Ohno, K., Uetsuka, K., Nakashima, K., Setoguchi, A., Fujino, Y., Tsujimoto, H., 2007: Measurement of intestinal mucosal permeability in dogs with lymphocytic-plasmacytic enteritis. J. Vet. Med. Sci., 69, 745‒749. DOI: 10.1292/jvms.69.745.
  31. Langlois, D. K., Pritchard, J. C., Tolbert, M. K., Jergens, A. E., Block, G., Hanzlicek, A., et al., 2023: Clinical utility of immunoglobulin A-based serological panel for the diagnosis of chronic enteropathy in dogs. J. Vet. Intern. Med., 37, 446‒454. DOI: 10.1111/jvim.16636.
  32. Nestler, J., Syrjä, R., Kilpinen, S., Moniz, C. A., Spill-mann, T., Hanifeh, M., et al., 2024: Duodenal and colonic mucosal S100A8/A9 (calprotectin) expression is increased and correlates with the severity of select histologic lesions in dogs with chronic inflammatory enteropathy. BMC Vet. Res., 20, 393. DOI: 10.1186/s12917-024-04256-9.
  33. O’Neill, D. G., James, H., Brodbelt, D. C., Church, D. B., Pegram, C., 2021: Prevalence of commonly diagnosed disorders in UK dogs under primary veterinary care: Results and applications. BMC Vet. Res., 17, 69. DOI: 10.1186/s12917-021-02775-3.
  34. Otoni, C. C., Heilmann, R. M., Garcia-Sancho, M., Sainz, A., Ackermann, M. R., Suchodolski, J. S., et al., 2018: Serologic and faecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease. J. Vet. Intern. Med., 32, 999‒1008. DOI: 10.1111/jvim.15123.
  35. Pilla, R., Suchodolski, J. S., 2020: The role of the canine gut microbiome and metabolome in health and gastrointestinal disease. Front. Vet. Sci., 6, 498. DOI: 10.3389/ fvets.2019.00498.
  36. Sacoor, C., Barros, L. M., Montezinho, L., 2020: What are the potential biomarkers that should be considered in diagnosing and managing canine chronic inflammatory enter-opathies? Open Vet. J., 10, 4, 412‒430. DOI: 10.4314/ovj. v10i4.9.
  37. Simpson, K. W., Jergens, A. E., 2011: Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease. Vet. Clin. Small Anim., 41, 381‒398. DOI: 10.1016/j.cvsm.2011.02.003.
  38. Suchodolski, J. S. Markel, M. E., Garcia-Mazcorro, J. F., Unterer, S., Heilmann, R. M., Dowd, S. E., et al., 2012: The faecal microbiome in dogs with acute diarrhoea and idiopathic inflammatory bowel disease. PLOS ONE, 7, 12, e51907 DOI: 10.1371/journal.pone.0051907.
  39. Suchodolski, J. S., 2016: Diagnosis and interpretation of intestinal dysbiosis in dogs and cats. Vet. J., 215, 30‒37. DOI: 10.1016/j.tvjl.2016.04.011.
  40. Volkmann, M., Steiner, J. M., Fosgate, G. T., Zentek, J., Hartmann, S., Kohn, B., 2017: Chronic diarrhoea in dogs ‒ retrospective study in 136 cases. J. Vet. Intern. Med., 31, 1043‒1055. DOI: 10.1111/jvim.14739.
  41. Weber, M. P., Martin, L. J., Dumon, H. J., Giorge, V. C., Nguyen, P. G., 2002: Influence of age and body size on intestinal permeability and absorption in healthy dogs. Am. J. Vet. Res., 63, 1323‒1328. DOI: 10.2460/ajvr.2002.63.1323.
DOI: https://doi.org/10.2478/fv-2024-0039 | Journal eISSN: 2453-7837 | Journal ISSN: 0015-5748
Language: English
Page range: 54 - 61
Submitted on: Oct 16, 2024
|
Accepted on: Nov 11, 2024
|
Published on: Dec 17, 2024
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2024 Maria Fialkovičová, Marta Benková, Csilla Tóthová, Kristin Maria Kejr, Lukáš Kunay, Simona Gomulcová, Ľubica Horňáková, Martina Karasová, Bohumil Bielik, Martina Takáčová, Tatiana Weissová, published by The University of Veterinary Medicine and Pharmacy in Košice
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.