Contribution of Pili of S. Pneumoniae in the Onset of Meningitis

Jiménez-Munguía, I.; Pulzová, L.; Bhide, K.; Čomor, Ľ.; Káňová, E.; Tomečková, Z.; Širochmanová, I.; Bhide, M.

doi:10.2478/fv-2018-0010

Abstract

Bacterial meningitis is a devastating worldwide disease. Half of the survivors of meningitis remain with permanent neurological sequelae. The pathogenesis of meningitis is based on a complex host-pathogen interaction. Streptococcus pneumoniae is a life-threatening neuroinvasive pathogen that asymptomatically colonizes the upper respiratory tract. Adherence of pneumococci to the host epithelium is a prerequisite in the onset of streptococcal infections; such adherence is favored by the formation of bacterial pili. In this article, we will describe the pneumococcal pili and its contribution to the onset of meningitis.

References

1. Bagnoli, F., Moschioni, M., Donati, C., Dimitrovska, V., Ferlenghi, I., Facciotti, C., et al., 2008: A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells. J. Bacteriol., 190, 5480—5492.10.1128/JB.00384-08249325618515415
Search in Google Scholar Back to article
2. Barichello, T., Generoso, J. S., Collodel, A., Moreira, A. P., Almeida, S. M. De., 2012: Pathophysiology of acute meningitis caused by Streptococcus pneumoniae and adjunctive therapy approaches. Arquivos de neuro-psiquiatria, 70, 366—372. http://www.ncbi.nlm.nih.gov/pubmed/22618789.10.1590/S0004-282X2012000500011
Search in Google Scholar Back to article
3. Barocchi, M. A., Ries, J., Zogaj, X., Hemsley, C., Albiger, B., Kanth, A., et al., 2006: A pneumococcal pilus influences virulence and host inflammatory responses. In Proc. Natl. Acad. Sci. USA. 103, 2857—2862. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1368962&tool=pmcentrez&rendertype=abstract (4 March 2015).10.1073/pnas.0511017103136896216481624
Search in Google Scholar Back to article
4. Burnaugh, A. M., Frantz, L. J. and King, S. J., 2008: Growth of Streptococcus pneumoniae on human glycoconjugates is dependent upon the sequential activity of bacterial exoglycosidases. J. Bacteriol., 190, 221—230.10.1128/JB.01251-07222375217981977
Search in Google Scholar Back to article
5. Danne, C., Dramsi, S., 2012: Pili of Gram-positive bacteria: Roles in host colonization. Research in Microbiology, 163, 645—658. http://dx.doi.org/10.1016/j.resmic.2012.10.012.10.1016/j.resmic.2012.10.01223116627
Open DOI Search in Google Scholar Back to article
6. Doran, K. S., Fulde, M., Gratz, N., Kim, B. J., Nau, R., Prasadarao, N., et al., 2016: Host-pathogen interactions in bacterial meningitis. Acta Neuropathologica, 131, 185—209.10.1007/s00401-015-1531-z471372326744349
Search in Google Scholar Back to article
7. Dramsi, S., Caliot, E., Bonne, I., Guadagnini, S., Prévost, M. C., Kojadinovic, M., et al., 2006: Assembly and role of pili in group B streptococci. Molecular Microbiology, 60, 1401—1413.10.1111/j.1365-2958.2006.05190.x16796677
Open DOI Search in Google Scholar Back to article
8. El Mortaji, L., Fenel, D., Vernet, T., Di Guilmi, A. M., 2012: Association of RrgA and RrgC into the Streptococcus pneumoniae pilus by sortases C-2 and C-3. Biochemistry, 51, 342—352.10.1021/bi201591n22122269
Search in Google Scholar Back to article
9. Gurung, M., Moon, D. C., Choi, C. W., Lee, J. H., Bae, Y. C., Kim, J., et al., 2011:Staphylococcus aureus produces membrane-derived vesicles that induce host cell death. PLoS ONE, 6, 1—8.10.1371/journal.pone.0027958321807322114730
Search in Google Scholar Back to article
10. Hilleringmann, M., Giusti, F., Baudner, B. C., Masignani, V., Covacci, A., Rappuoli, R., et al., 2008: Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A. PLoS Pathogens, 4, e1000026.10.1371/journal.ppat.1000026226543018369475
Search in Google Scholar Back to article
11. Hilleringmann, M., Ringler, P., Müller, S. A., De Angelis, G., Rappuoli, R., Ferlenghi, I., et al., 2009: Molecular architecture of Streptococcus pneumoniae TIGR4 pili. The EMBO Journal, 28, 3921—3930. http://emboj.embopress.org/cgi/doi/10.1038/emboj.2009.360.10.1038/emboj.2009.360
Open DOI Search in Google Scholar Back to article
12. Honda, E., Yanagawa, R., 1978: Pili-mediated attachment of Corynebacterium renale to mucous membrane of urinary bladder of mice. Am. J. Vet. Res., 39, 155—158.
Search in Google Scholar Back to article
13. Iovino, F., Hammarlöf, D. L., Garriss, G., Brovall, S., Nannapaneni, P., Henriques-Normark, B., 2016: Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA. J. Clin. Invest., 126, 2821—2826.10.1172/JCI84705
Search in Google Scholar Back to article
14. Izoré, T., Contreras-Martel, C., El Mortaji, L., Manzano, C., Terrasse, R., Vernet, T., et al., 2010: Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae. Structure, 18, 106—115.10.1016/j.str.2009.10.019
Search in Google Scholar Back to article
15. Jayaraman, R., 2011: Phase variation and adaptation in bacteria: A ‘Red Queen’s Race’. Current Science, 100, 1163—1171.
Search in Google Scholar Back to article
16. Kim, K. S., 2008: Mechanisms of microbial traversal of the blood-brain barrier. Nature reviews. Microbiology, 6, 625—34. http://dx.doi.org/10.1038/nrmicro1952 (23 March 2016).10.1038/nrmicro1952(232016)
Open DOI Search in Google Scholar Back to article
17. Marraffini, L. A., DeDent, A. C., Schneewind, O., 2006: Sortases and the art of anchoring proteins to the envelopes of Gram-positive bacteria. Microbiol. Mol. Biol. Rev., 70, 192—221. http://mmbr.asm.org/cgi/doi/10.1128/MMBR.70.1.192-221.2006.10.1128/MMBR.70.1.192-221.2006139325316524923
Open DOI Search in Google Scholar Back to article
18. Meli, D. N., Christen, S., Leib, S. L., Täuber, M. G., 2002: Current concepts in the pathogenesis of meningitis caused by Streptococcus pneumoniae. Cur. Opin. Infect. Dis., 15, 253—257. http://www.ncbi.nlm.nih.gov/pubmed/12015459 (15 January 2016).10.1097/00001432-200206000-0000712015459
Search in Google Scholar Back to article
19. Mook-Kanamori, B. B., Geldhoff, M., Der, T. Van, van der Poll, T. B., van de Eek, D., 2011: Pathogenesis and pathophysiology of pneumococcal meningitis. Clin. Microbiol. Rev., 24, 557—591.10.1128/CMR.00008-11313105821734248
Open DOI Search in Google Scholar Back to article
20. Muñoz-Elías, E. J., Marcano, J., Camilli, A., 2008: Isolation of Streptococcus pneumoniae biofilm mutants and their characterization during nasopharyngeal colonization. Infect. Immun., 76, 5049—5061.10.1128/IAI.00425-08257332118794289
Open DOI Search in Google Scholar Back to article
21. Nelson, A. L., Ries, J., Bagnoli, F., Dahlberg, S., Fälker, S., Rounioja, S., et al., 2007: RrgA is a pilus-associated adhesin in Streptococcus pneumoniae. Mol. Microbiol., 66, 329—340.10.1111/j.1365-2958.2007.05908.x217053417850254
Open DOI Search in Google Scholar Back to article
22. Oggioni, M. R., Trappetti, C., Kadioglu, A., Cassone, M., Iannelli, F., Ricci, S., et al., 2006: Switch from planktonic to sessile life: A major event in pneumococcal pathogenesis. Mol. Microbiol., 61, 1196—1210.10.1111/j.1365-2958.2006.05310.x161875916925554
Open DOI Search in Google Scholar Back to article
23. Ponting, C. P., Aravind, L., Schultz, J., Bork, P., Koonin, E. V., 1999: Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. J. Mol. Biol., 289, 729—745. http://linkinghub.elsevier.com/retrieve/pii/S0022283699928279.10.1006/jmbi.1999.282710369758
Search in Google Scholar Back to article
24. Ricci, S., Gerlini, A., Pammolli, A., Chiavolini, D., Braione, V., Tripodi, S. A., et al., 2013: Contribution of different pneumococcal virulence factors to experimental meningitis in mice. BMC Infect. Dis., 13, 444. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3848944&tool=pmcentrez&rendertype=abstract.10.1186/1471-2334-13-444384894424059458
Search in Google Scholar Back to article
25. Scheld, W. M., Whitley, R. J., Marra, C. M., 2004:Infections of the Central Nervous System. 1st edn., Williams & Wilkins, China, 353 pp.
Search in Google Scholar Back to article
26. Scott, J. R., Zähner, D., 2006: Pili with strong attachments: Gram-positive bacteria do it differently. Mol. Microbiol., 62, 320—330.10.1111/j.1365-2958.2006.05279.x16978260
Open DOI Search in Google Scholar Back to article
27. Spraggon, G., Koesema, E., Scarselli, M., Malito, E., Biagini, M., Norais, N., et al., 2010: Supramolecular organization of the repetitive backbone unit of the Streptococcus pneumoniae pilus. PLoS ONE, 5, e10919.10.1371/journal.pone.0010919288610920559564
Search in Google Scholar Back to article
28. Springer, T. A., 2006: Complement and the multifaceted functions of VWA and integrin I domains. Structure, 14, 1611—161.10.1016/j.str.2006.10.001171238517098186
Search in Google Scholar Back to article
29. Tuomanen, E. I., 1996: Molecular and cellular mechanisms of pneumococcal meningitis. Ann. NY Acad. Sci., 797, 42—52.10.1111/j.1749-6632.1996.tb52948.x8993350
Search in Google Scholar Back to article
30. Van de Beek, D., Brouwer, M., Hasbun, R., Koedel, U., Whitney, C. G., Wijdicks, E., 2016: Community-acquired bacterial meningitis. Nat. Rev. Dis. Primers, 2, 1—20. http://www.nature.com/articles/nrdp201674.10.1038/nrdp.2016.7427808261
Search in Google Scholar Back to article
31. Zähner, D., Gandhi, A. R., Stuchlik, O., Reed, M., Pohl, J., Stephens, D. S., 2011: Pilus backbone protein PitB of Streptococcus pneumoniae contains stabilizing intramolecular isopeptide bonds. Biochem. Biophys. Res. Comm., 409, 526—531.10.1016/j.bbrc.2011.05.038311417321600877
Search in Google Scholar Back to article

Contribution of Pili of S. Pneumoniae in the Onset of Meningitis

Abstract

Paradigm

My account