The Role of Meningococcal Porin B in Protein-Protein Interactions with Host Cells

E. Káňová; I. Jiménez-Munguía; Ľ. Čomor; Z. Tkáčová; I. Širochmanová; K. Bhide; M. Bhide

doi:10.2478/fv-2018-0008

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The Role of Meningococcal Porin B in Protein-Protein Interactions with Host Cells

Folia Veterinaria

Volume 62 (2018): Issue 1 (March 2018)

By: E. Káňová, I. Jiménez-Munguía, Ľ. Čomor, Z. Tkáčová, I. Širochmanová, K. Bhide and M. Bhide

Open Access

|Apr 2018

Abstract

Neisseria meningitidis is a Gram-negative diplococcus responsible for bacterial meningitis and fatal sepsis. Ligand-receptor interactions are one of the main steps in the development of neuroinvasion. Porin B (PorB), neisserial outer membrane protein (ligand), binds to host receptors and triggers many cell signalling cascades allowing the meningococcus to damage the host cells or induce immune cells responses via the TLR2-dependent mechanisms. In this paper, we present a brief review of the structure and function of PorB.

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Articles in this issue

DOI: https://doi.org/10.2478/fv-2018-0008 | Journal eISSN: 2453-7837 | Journal ISSN: 0015-5748

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Language: English

Page range: 52 - 58

Submitted on: Dec 4, 2017

Accepted on: Jan 26, 2018

Published on: Apr 11, 2018

Published by: The University of Veterinary Medicine and Pharmacy in Košice

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

Neisseria meningitidis,

PorB,

protein,

Related subjects:

Microbiology and virology,

Medicine,

Veterinary medicine

© 2018 E. Káňová, I. Jiménez-Munguía, Ľ. Čomor, Z. Tkáčová, I. Širochmanová, K. Bhide, M. Bhide, published by The University of Veterinary Medicine and Pharmacy in Košice
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 62 (2018): Issue 1 (March 2018)