Figure 1.

Characteristics of the included studies_
| Study, country | Study design | Sample | Data collection | Data analysis | Facility type |
|---|---|---|---|---|---|
| Abusalem et al.28, USA | Quantitative, crosssectional | N = 252 direct care workers | Questionnaire | Descriptive and inferential statistics | Non-specified |
| Andersson et al.29, Sweden | Quantitative, retrospective | N = 173 reports | AEs reports | Content analysis, descriptive statistics | Nursing home |
| Aranda-Gallardo et al.30, Spain | Quantitative, prospective | N = 647 residents | Questionnaire | Descriptive and inferential statistics | Nursing home |
| Boockvar et al.31, USA | Quantitative | N = 122 residents | Residents’ documentation | Descriptive and inferential statistics | Nursing home |
| Crespin et al.32, USA | Quantitative, cross-sectional | N = 15 037 reports | AEs reports | Descriptive and inferential statistics | Nursing home |
| Daneman et al.33, Canada | Quantitative, cohort | N = 110 656 residents | AEs reports | Descriptive and inferential statistics | Nursing home |
| Djikstra et al.34, Netherland | Quantitative, crosssectional | N = 13 633 residents | Questionnaire | Descriptive and inferential statistics | Nursing home |
| Doupe et al.35, Canada | Quantitative, cohort | N = 22 846 residents | Administrative data | Descriptive and inferential statistics | Nursing home |
| Gerety et al.36, USA | Quantitative, retrospective | N = 175 residents | Residents’ documentation | Descriptive and inferential statistics | Nursing home |
| Glette et al.37, Norway | Qualitative, comparative | N = 17 nurses and nurse managers | Semi-structured interviews | Content analysis | Nursing home |
| Gurwitz et al.38, USA | Quantitative, retrospective | N = 490 residents | Residents’ documentation | Descriptive and inferential statistics | Nursing home |
| Halligan et al.39, Canada | Mixed method | N = 26 direct care workers | Questionnaire, semistructured interviews | Descriptive statistics; content analysis | Non-specified |
| Herrmann et al.40, Canada | Quantitative | N = 24 residents | Questionnaire | Descriptive and inferential statistics | Non-specified |
| Hughes et al.41, USA | Quantitative, retrospective | N = 8267 residents | Questionnaire | Descriptive and inferential statistics | Nursing home |
| Kapoor et al.42, USA | Quantitative, prospective | N = 555 residents | Residents’ documentation | Descriptive and inferential statistics | Non-specified |
| Kapoor et al.43, USA | Quantitative, prospective | N = 555 residents | Residents’ documentation | Descriptive and inferential statistics | Nursing home |
| Lannering et al.44, Sweden | Quantitative, longitudinal | N = 429 residents | Questionnaire | Descriptive and inferential statistics | Nursing home |
| Lexow et al.45, Germany | Quantitative, crosssectional | N = 104 residents | Interviews, residents’ documentation, medication analysis | Descriptive and inferential statistics | Non-specified |
| Lindblad et al.46, Sweden | Quantitative, retrospective | N = 518 records | Residents’ documentation | Descriptive and inferential statistics | Nursing home |
| Lindblad et al.47, Sweden | Quantitative, retrospective | N = 600 records | Residents’ documentation | Descriptive and inferential statistics | Nursing home |
| Lombardo et al.48, Italy | Quantitative | N = 1356 residents | Questionnaire | Descriptive and inferential statistics | Nursing home |
| McDonald et al.49, USA | Quantitative | N = 50 residents | Residents’ documentation | Descriptive and inferential statistics | Nursing home |
| Niznik et al.50, USA | Quantitative, retrospective | N = 37,106 residents | Residents’ documentation | Descriptive and inferential statistics | Nursing home |
| Oliveria et al.51, USA | Quantitative, retrospective | N = 7728 residents | Questionnaire | Descriptive and inferential statistics | Nursing home |
| Prang and Jelsness-Jorgensen52, Norway | Qualitative | N = 13 nurses | Semi-structured interviews | Thematic analysis | Nursing home |
| Quach et al.53, USA | Quantitative, crosssectional | N = 56 nurses | Questionnaire | Descriptive and inferential statistics | Nursing home, community center |
| Resnik and Galik54, USA | Secondary analysis | N = 199 residents | Questionnaire | Descriptive and inferential statistics | Nursing home, residential care |
| Shmueli et al.55, Israel | Quantitative, descriptive | N = 1364 reports | AEs reports | Descriptive and inferential statistics | Non-specified |
| Trinks et al.56, Sweden | Quantitative, retrospective | N = 40,224 residents | AEs reports | Descriptive and inferential statistics | Nursing home, hospital |
| Van Gaal et al.57, Netherland | Quantitative, prospective | N = 687 patients | Residents’ documentation | Descriptive and inferential statistics | Nursing home, hospital |
| Wagner et al.58, USA | Quantitative, crosssectional | N = 289 nurses | Questionnaire | Descriptive and inferential statistics; content analysis | Non-specified |
| Wagner et al.59, USA | Quantitative | N = 399 managers of nursing homes | Questionnaire | Descriptive and inferential statistics | Nursing home |
| Wagner et al.60, USA | Quantitative | N = 32 states; healthcare departments | Questionnaire | Descriptive and inferential statistics | Nursing home |
| Wang et al.61, Australia | Quantitative, casecontrol | N = 332 cases | Residents’ documentation | Descriptive and inferential statistics | Non-specified |
| Yu and Perng62, Taiwan, China | Quantitative, crosssectional | N = 213 nurse aids | Questionnaire | Descriptive and inferential statistics | Non-specified |
AEs impacting physical functioning in LTC facilities_
| AEs impacting physical functioning | Examples of references |
|---|---|
| Falls | Abusalem et al.28; Andersson et al.29; Aranda-Gallardo et al.30; Doupe et al.35; Herrmann et al.40; Kapoor et al.42; Kapoor et al.43; Lannering et al.44; Lexow et al.45; Lindblad et al.46; Lindblad et al.47; Lombardo et al.48; Prang and Jelsness-Jorgensen52; Quach et al.53; Resnick and Galik54; Shmueli et al.55; Trinks et al.56; Van Gaal et al.57; Wagner et al.58; Wagner et al.60; Yu and Perng62 |
| Pressure ulcers | Abusalem et al.28; Dijkstra et al.34; Doupe et al.35; Kapoor et al.42; Kapoor et al.43; Lannering et al.44; Lexow et al.45; Lindblad et al.46; Lombardo et al.48; Quach et al.53; Trinks et al.56; Van Gaal et al.57; Wagner et al.60; Yu and Perng62 |
| Medication errors | Andersson et al.29; Boockvar et al.31; Crespin et al.32; Gerety et al.36; Gurwitz et al.38; Kapoor et al.42; Lindblad et al.46; Lindblad et al.47; Prang and Jelsness-Jorgensen52; Shmueli et al.55; Wagner et al.58; Wagner et al.60; Yu and Perng62 |
| Infections | Abusalem et al.28; Boockvar et al.31; Daneman et al.33; Doupe et al.35; Gurwitz et al.38; Kapoor et al.42; Lexow et al.45; Lombardo et al.48; Oliveria et al.51; Quach et al.53; Van Gaal et al.57; Wagner et al.60 |
| Gastrointestinal problems | Boockvar et al.31; Daneman et al.33; Gerety et al.36; Gurwitz et al.38; Hughes et al.41; Herrmann et al.40; Kapoor et al.42; Lannering et al.44; Lexow et al.45; Lindblad et al.46; Lindblad et al.47; Lombardo et al.48; Oliveria et al.51; Trinks et al.56 |
| Cardiovascular problems | Boockvar et al.31; Gerety et al.36; Gurwitz et al.38; Kapoor et al.42; Lexow et al.45; Lindblad et al.46; Oliveria et al.51 |
| Neurological problems | Boockvar et al.31; Gerety et al.36; Gurwitz et al.38; Herrmann et al.40; Hughes et al.41; Lexow et al.45; Lindblad et al.46; Oliveria et al.51 |
| Skin problems | Herrmann et al.40; Kapoor et al.42; Kapoor et al.43; Lexow et al.45; Lindblad et al.46; Oliveria et al.51; Wagner et al.60; Yu and Perng62 |
| Musculoskeletal problems | Boockvar et al.31; Doupe et al.35; Gerety et al.36; Lexow et al.45; Niznik et al.50; Oliveria et al.51 |
| Hemorrhagic complications | Gurwitz et al.38; Kapoor et al.42; Lexow et al.45; Oliveria et al.51 |
| Respiratory problems | Kapoor et al.42; Lexow et al.45 |
| Non-categorized: | Daneman et al.33; Gerety et al.36; Gurwitz et al.38; Kapoor et al.42; Lexow et al.45; Lindblad et al.46; Lindblad et al.47; Lombardo et al.48; Niznik et al.50; Oliveria et al.51; Yu and Perng62 |
AEs impacting psychological functioning in LTC facilities_
| AEs impacting psychological functioning | Examples of references |
|---|---|
| Agitation | Gerety et al.36; Herrmann et al.40; Kapoor et al.42; Lexow et al.45; Lindblad et al.47; Lombardo et al.48; Oliveria et al.51 |
| Pain | Boockvar et al.31; Lexow et al.45; Lindblad et al.46; Lindblad et al.47; Oliveria et al.51 |
| Change in mental status | Lindblad et al.46; Lindblad et al.47; Lombardo et al.48; Lexow et al.45 |
| Hospitalization | Glette et al.37; Gerety et al.36; Lindblad et al.46; McDonald et al.49; Niznik et al.50; Oliveria et al.51; Resnick and Galik54 |
| Alteration in behaviour | Lindblad et al.46; Lexow et al.45; Lombardo et al.48 |
| Errors in communication about residents | Lindblad et al.46; Lindblad et al.47; Wagner et al.58 |
| Delirium | Kapoor et al.42; Lombardo et al.48; Oliveria et al.51 |
| Anxiety | Lexow et al.45; Lindblad et al.46; Oliveria et al.51 |
| Suicidal behaviour | Andersson et al.29; Wagner et al.60 |
| Violence | Shmueli et al.55; Wagner et al.60 |
| Hallucinations | Gerety et al.36; Lexow et al.45 |
| Lethargy | Boockvar et al.31; Lexow et al.45 |
| Self-injury | Shmueli et al.55 |
| Abuse (physical, sexual) | Wagner et al.60 |
| Personality change | Lexow et al.45 |
| Delays in diagnosis or treatment | Kapoor et al.42 |
| Escape of resident | Yu and Perng62 |
| Depression | Lexow et al.45 |
| Suicide | Wagner et al.60 |
Resources and methods of collecting the data in analyzed studies_
| Resources and methods | Examples of references |
|---|---|
| Reporting systems | |
| Centers for Medicare and Medicaid Services | Abusalem et al.28; McDonald et al.49; Niznik et al.50 |
| Health and Social Care Inspectorate | Andersson et al.29 |
| Medication Error Quality Initiative - Individual Error System | Daneman et al. 33 |
| Veterans’ Health Administration Office of Reporting, Analytics, Performance, Improvement & Deployment | Quach et al.53 |
| Computerized AE Management System | Shmueli et al.55 |
| the Taiwan Patient Safety Reporting System | Yu and Perng62 |
| Minimum Data Set | Hughes et al.41; Oliveria et al.51 |
| Instruments | |
| The Dutch National Prevalence Survey of Care Problems | Djikstra et al.34 |
| The Modified Stanford Patient Safety Culture Survey Instrument | Halligan et al.39 |
| Risk assessment tools | Lindblad et al.46; Van Gaal et al.57 |
| Trigger tool | Lindblad et al.46; Lindblad et al.47 |
| National Survey on AEs | Lombardo et al.48 |
| Senior Alert,56 | Trinks et al.56 |
| The Communicating about Nursing Error Survey | Wagner et al.58 |
| The Survey on AEs,59 | Wagner et al.59 |
| The State Incident Reporting Policies and Practices.60 | Wagner et al.60 |
| Other methods | |
| Residents’ records | Boockvar et al.31; Gerety et al.36; Gurwitz et al.38; Kapoor et al.42; Kapoor et al.43; Wang et al.61 |
| Residents’ records in combination with risk assessment tools | Herrmann et al.40 |
| Interviews | Glette et al.37; Lexow et al.45; Prang and Jelsness-Jorgensen52 |
| Verification of the record by caregiver and residents themselves | Aranda-Gallardo et al.30 |
| Population-based administrative databases | Daneman et al.33; Doupe et al.35 |
| Cumulative count of AEs | Resnick and Galik54 |
The search process in scientific databases PubMed, Scopus, and ProQuest_
| Search words | Hits |
|---|---|
| (“Care, Long-Term” [Mesh] OR “Long Term Care” [Mesh] OR “Facilities, Residential” [Mesh] OR “Facility, Residential” [Mesh] OR “Residential Facility” [Mesh] OR “Nursing Home” [Mesh] OR “Homes, Nursing” [Mesh] OR “Old Age Homes” [Mesh] OR “Home, Old Age” [Mesh] OR “Homes, Old Age” [Mesh] OR “Old Age Home” [Mesh]) AND (“adverse event*”) | PubMed: 435 |
| (“long-term care” OR “long term care” OR “nursing home*” OR “residential facility*” OR “old age home*”) AND (“adverse event*”) | Scopus: 220 |
| Total | 1057 |