| Daniel Langer/2015/USA | C: 10I: 10Age: >75Stable COPD | MTL IMT—mechanical threshold loading (MTL) | TFRL IMT— tapered flow resistive loading (TFRL) | 8 weeks | -Inspiratory muscle strength-Inspiratory muscle endurance-PF |
| Dimitra Nikoletou/2015/Britain | C: 34;I: 34.Stages: moderate to severeAge: >50 years | BEIMT with a threshold loading device | Not to train the respiratory muscles | 7 weeks | -PImax-SNIP-diaphragm contractility (Pdi,tw)-ISWT-RME-CRDQ-HADS-the SF-36 |
| Fahrahnaz Mohammadi/2015/Iran | 40 patients:I: 20C: 20Stages: GOLD 2–3Age: no limit | EDU+LLE+BEThree one-hour sessions of face-to-face + the correct methods of walking + drug therapy | Drug therapy. | 7 weeks | -SF-12-FSS-BI |
| Marieke L Duiverman/2011/The Netherlands | I: 24C: 32Stages: III or IVAges: 40–76 | EDU 12 weeksNIPPV+PR | At home:EDU 12 weeksPR | 6, 12, 18, 24 M | -CRQ-MRF-28-GARS-HADS-FEV1-MRC-6MWD |
| María Rosa Güell/2007/Spain | 51 patients:I: 23C: 28Stage IIIAge:I: 66 (5.8)C: 63.2 (6.6) | EDU+BE\ULE\LLE:unsupervised street walking daily at a pace of 4 km/h marked by a podometerwent up and down stairs for 5 minutes before and after each walk | Hospital:EDU+BE\ULE\LLE: | 3 times per week | Respiratory muscle function.Arm muscle exercise tests.Leg muscle exercise test.CRQ |
| Juliana M. de Sousa Pinto/2014/Spain | I: 29C: 21Stages: severe and very severeAge: <80 | BE+ULE+LLEEndurance training: walking, stair climbing, cycling.standard medical therapy + inhaler devices and nebulizer therapy. | At home:standard medical therapy + the nursing counseling session. | 12 weeks | -The Spirometer Jaeger MasterScope model-SGRQ-LCADL-6MWD-The Borg scale-a pulse oximeter |
| Atsuyoshi Kawagoshi/2014/Japan | I: 20C: 19Stage: stableAge: Elderly aged | BE+ULE+LLEPR + pedometer use | At home:BE+ULE+LLEPP | 1 Y | -CRQ-BODE-6MWD-FVC-FVC1 |
| Tristan Bonnevie/2018/France | C: 27; I: 24 Stages: severe to very severeAge: >18 years | BE+ULE+LLENMES | Outpatient or home:EDU+BE+ULE+LLEmuscle strength training | 8 weeks | -6MWT-VO2peak-Wmax-mMRC-SGRQ |
| Xujingjuan/2016/China | C: 62; I: 63Stages: modified or above | BE+ULE+LLEImproved lung-rehabilitation training program (including breathing training + routine care) + relaxation training +LLE +ULE | BEincluding breathing training + routine care | 12 weeks | -6MWT-mMRC-PF-SGRQ |
| Fernanda Dultra Dias/2013/Brazil | I: 13C: 10.Stages: stableAge: >40 | EDU+BE+LLEa protocol at home with aerobic and muscle strength exercises | EDUonly instructions to perform breathing and stretching exercises | 2 M | -ISWT and VLIT-strength and endurance test (MIP and MEP)-AQ-20 |
| W-T. Liu/2008/Taiwan, China | 48 patients:I: 24C: 24Stages: moderate to severeAge: 40–80 years | LLE:Walking at a speed following the tempo of the music | At home:same protocol and take daily walking exercise | 4 weeks for 3 M and again after 1 yr | -PF-ISWT-SF-12-BMI |
| Chiung-Fang Ho/2012/Taiwan, China | 41 patients:I: 20C: 21Stage II–IIIAge: 74 ± 10.3 years | LLE:The paced walking to music.at initial speed was set at 80% VO2 peak and increased gradually. | At Home:Receive the usual care. | 12 weeks | -ISWT-PFT-HRQOL-SGRQ-Health resource utility |
| Marcel du Moulin/2009/Germany | 20 patients:I: 10C: 10Stage: moderateAge:I: 67 (63–72)C: 72 (69–77) | EDU+3WReceive an individualized training plan.LLE:daily activities. (walking) with a pedometer | EDU+3Wcarry out their activities of daily living in their accustomed way. | after 3 M and 6 M. | -CRQ-PFT-6MWT |
| Elizabeth J Horton/2017/UK | C: 142I: 145Stages: 2–5Mean age: 68 | LLEStructure unsupervised home exercise | Center-based exercise: LLE | 7 W;6 M | -CRQ-SR-HADS-PRAISE-ISWT-ESWT |
| P.de Roos/2016/Holland | C: 26I: 26Stages: Stable and moderateMean age: 69.4 and 71.0 | LLE10 week supervised exercise training and home-based walk. | Center-based: standard medical care | 10 weeks | -The accelerometry-Physical Activity Scale for the Elderly;-6MWT;-CRQ;-Exercise Self-Regulatory Efficacy Scale |
| Wangxin/2013/China | I: 17C: 18Stages: very severeAge: 58–74 years | LLE+Oxygen therapy + drug therapy + noninvasive positiveExercise under pressure ventilation | Oxygen therapy + drug therapy | 6 M | -6MWD-Brog-SGRQ |
| Cristiane O Pradella/2015/Brazil | I: 29C: 15Age: 40–75 yearrs | LLE+ULE(1) warm-up, (2) aerobic activity, (3) stretching, and (4) relaxation. | At home:no intervention. | 8 weeks | -SGRQ-6MWT-treadmill endurance test-spirometry |
| Júlio C/2010/Italy | 85 patients:HOME: 33Outpatient: 29C: 23Stage: GOLD I–IVAge:H: 66.4 ± 9.5O: 71.3 ± 6.7C: 70.8 ± 8.7 | (1) EDULLE+ULEAerobic=walks on flat ground and strengthening exercises(2) Outpatient:EDUULE+LLEaerobic and strengthening exercises | (3) C: At homeNot perform any PR | three mornings a week for three months. | -BMI-6MWT-BODE-mMRC dyspnea scale |
| Anne E Holland/2016/Australia | C: 86I: 80Stages: stableMean age: 69 | Structure Home Exercise (aerobic\LLE) with Physical Therapists Visiting and Telephone Supervision | Outpatient:twice weekly outpatient group-based supervised program, | 8 weeks1 Y | -6MWD-modified Medical Research Council dyspnea scale-CRQ-PRAISE-HADS |
| François Maltais/2008/America | 252 patients:I: 126C: 126Stages: II–IVMean age: 66 | EDU+Aerobic and strength exercise: ? | Outpatient:EDU+LLE:Leg cycling | 8 weeks | -CRQ-SGRQ-PFT-6MWT |
| Carol McFarland, P T/2012/America | I: 13C: 11Stages: Mild and moderateMean ages: 72.2 and 76.2 | Home visits +EDUA: aerobic conditioning | Home visits +EDUB: At home:functional strength training | 8 weeks16 weeks | -CRQ-Geriatric Depression Scale (GDS)-2MWT |
