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Outcomes of patients with localized prostate cancer treated with combined external beam radiotherapy and high-dose-rate brachytherapy boost: A single-center retrospective study Cover

Outcomes of patients with localized prostate cancer treated with combined external beam radiotherapy and high-dose-rate brachytherapy boost: A single-center retrospective study

Open Access
|Jun 2024

Figures & Tables

Treatment characteristics_

CharacteristicValue
External radiotherapy technique
3DCRT24 (18.9)
H-IMRT103 (81.1)
External radiotherapy dose (cGy)
450084 (66.1)
375043 (33.9)
WPRT
Yes74 (58.3)
No53 (41.7)
Number of HDR-BT applications
One24 (18.9)
Two103 (81.1)

Treatment-related toxicities_

Adverse eventsGrade
12345
Acute
Dysuria8 (6.3)0000
Haematuria05 (3.9)000
Urinary urgency/frequency4 (3.1)0000
Urinary tract obstruction10 (7.9)1 (0.8)1 (0.8)00
Rectal bleeding6 (4.7)0000
Anal pain00000
Late
Dysuria2 (1.6)0000
Hematuria4 (3.1)4 (3.1)000
Urinary urgency/frequency6 (4.7)0000
Urinary tract obstruction4 (3.1)3 (2)2 (1.6)00
Rectal bleeding4 (3.1)0000
Anal pain00000

Characteristics of patients and tumors_

CharacteristicValue
Total number of patients127
Age (years)
Median67
Range53–78
Pretreatment PSA
Range (ng/mL)2.90–81.21
PSA <10 ng/mL47 (37.0)
10 ≤ PSA < 20 ng/mL39 (30.7)
PSA ≥20 ng/mL41 (32.3)
Tumor stage
T1c22 (17.3)
T2a13 (10.2)
T2b10 (7.9)
T2c57 (44.9)
T3a21 (16.5)
T3b2 (1.6)
T42 (1.6)
Gleason score
≤611 (8.7)
790 (70.9)
8–1026 (20.5)
D’Amico risk group
Intermediate36 (28.3)
High91 (71.7)
DOI: https://doi.org/10.2478/fco-2023-0020 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
Language: English
Page range: 18 - 24
Submitted on: Aug 23, 2023
Accepted on: Dec 20, 2023
Published on: Jun 7, 2024
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2024 David Rothwell, Joana Costa Sousa, Ricardo Magalhães, Irina Guimarães, Beatriz Pires, João Pedro Barros, Regina Leite, Mónica Rodrigues, Carla Alves, Cristina Miranda, Gilberto Melo, Paula Alves, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.