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Hydroxyurea ulcers of unusual location: a case report and review of literature Cover

Hydroxyurea ulcers of unusual location: a case report and review of literature

Forum of Clinical Oncology
Volume 13 (2022): Issue 3 (December 2022)
By: Mansilla-Polo Miguel,  Navarro-Mira Miguel Ángel and  Botella-Estrada Rafael  
Open Access
|Nov 2023

Figures & Tables

Figure 1:

Lesions before discontinuation of hydroxyurea. (a and b) Numerous ulcers with well-defined borders located on the dorsum of the fingers can be seen. Also, appreciate the reddish hue on the back of the interphalangeal and metacarpophalangeal joints, creating a “pseudo-Gottron” pattern, like dermatomyositis. Nail brittleness and melanonychia are seen, features that are also widely described in urea toxicity. In (c), a dermatoscopic detail of the lesions can be seen, showing ulcers with very well-defined borders, with a whitish halo surrounded by another more erythematous one on the outside. The appearance of the ulcer is crusty and dry. (d) Shows detail of involvement in the palmar aspect.
Lesions before discontinuation of hydroxyurea. (a and b) Numerous ulcers with well-defined borders located on the dorsum of the fingers can be seen. Also, appreciate the reddish hue on the back of the interphalangeal and metacarpophalangeal joints, creating a “pseudo-Gottron” pattern, like dermatomyositis. Nail brittleness and melanonychia are seen, features that are also widely described in urea toxicity. In (c), a dermatoscopic detail of the lesions can be seen, showing ulcers with very well-defined borders, with a whitish halo surrounded by another more erythematous one on the outside. The appearance of the ulcer is crusty and dry. (d) Shows detail of involvement in the palmar aspect.

Figure 2:

Lesions after discontinuation of hydroxyurea. One month after discontinuation of therapy, the patient showed a notable improvement in the lesions (a), in the case of smaller and clinically asymptomatic ulcers. In (b), improvement is also seen at the palmar level.
Lesions after discontinuation of hydroxyurea. One month after discontinuation of therapy, the patient showed a notable improvement in the lesions (a), in the case of smaller and clinically asymptomatic ulcers. In (b), improvement is also seen at the palmar level.
DOI: https://doi.org/10.2478/fco-2023-0008 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
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Language: English
Page range: 62 - 65
Submitted on: Mar 22, 2023
Accepted on: Aug 17, 2023
Published on: Nov 13, 2023
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
Hydroxyurea,
Ulcers,
Side effects,
Hematology
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology

© 2023 Mansilla-Polo Miguel, Navarro-Mira Miguel Ángel, Botella-Estrada Rafael, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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