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Hydroxyurea ulcers of unusual location: a case report and review of literature Cover

Hydroxyurea ulcers of unusual location: a case report and review of literature

Forum of Clinical Oncology
Volume 13 (2022): Issue 3 (December 2022)
By: Mansilla-Polo Miguel,  Navarro-Mira Miguel Ángel and  Botella-Estrada Rafael  
Open Access
|Nov 2023
Figures & tables

Figures & Tables

Figure 1:

Lesions before discontinuation of hydroxyurea. (a and b) Numerous ulcers with well-defined borders located on the dorsum of the fingers can be seen. Also, appreciate the reddish hue on the back of the interphalangeal and metacarpophalangeal joints, creating a “pseudo-Gottron” pattern, like dermatomyositis. Nail brittleness and melanonychia are seen, features that are also widely described in urea toxicity. In (c), a dermatoscopic detail of the lesions can be seen, showing ulcers with very well-defined borders, with a whitish halo surrounded by another more erythematous one on the outside. The appearance of the ulcer is crusty and dry. (d) Shows detail of involvement in the palmar aspect.

Figure 2:

Lesions after discontinuation of hydroxyurea. One month after discontinuation of therapy, the patient showed a notable improvement in the lesions (a), in the case of smaller and clinically asymptomatic ulcers. In (b), improvement is also seen at the palmar level.
DOI: https://doi.org/10.2478/fco-2023-0008 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
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Language: English
Page range: 62 - 65
Submitted on: Mar 22, 2023
Accepted on: Aug 17, 2023
Published on: Nov 13, 2023
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year
Keywords:
Hydroxyurea,
Ulcers,
Side effects,
Hematology
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology

© 2023 Mansilla-Polo Miguel, Navarro-Mira Miguel Ángel, Botella-Estrada Rafael, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 13 (2022): Issue 3 (December 2022)
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