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Expression of the Non-classical HLA-E, -F, -G Molecules in the Tumour Microenvironment Cover

Expression of the Non-classical HLA-E, -F, -G Molecules in the Tumour Microenvironment

Forum of Clinical Oncology
Volume 13 (2022): Issue 1 (December 2022)
By:
Open Access
|Aug 2023

Figures & Tables

Figure 1:

Structure of the HLA-E, -F, and -G genes.
Structure of the HLA-E, -F, and -G genes.

Figure 2:

HLA-E expressed on a tumour cell, interacting with immune cells. Note: CD8+ = T cytotoxic cell; NK = natural killer cell.
HLA-E expressed on a tumour cell, interacting with immune cells. Note: CD8+ = T cytotoxic cell; NK = natural killer cell.

Figure 3:

HLA-F expressed on a tumour cell, interacting with NK and T cell receptors. Note: NK = natural killer cell; KIR3DL2 = Killer cell Immunoglobulin Like Receptor; ILT-2, -4 = inhibitory receptors Ig-like transcripts.
HLA-F expressed on a tumour cell, interacting with NK and T cell receptors. Note: NK = natural killer cell; KIR3DL2 = Killer cell Immunoglobulin Like Receptor; ILT-2, -4 = inhibitory receptors Ig-like transcripts.

Figure 4:

HLA-G expressed on a tumour cell, interacting with immune cell receptors. Note: CD8+ = T cytotoxic cell; CD4+ = T helper cell; Treg = T regulatory cell; NK = natural killer cell; DC = dendritic cell; Neu = neutrophil; ILT-2, -4 = inhibitory receptors Ig-like transcripts; KIR2DL4 = killer cell Ig-like receptor.
HLA-G expressed on a tumour cell, interacting with immune cell receptors. Note: CD8+ = T cytotoxic cell; CD4+ = T helper cell; Treg = T regulatory cell; NK = natural killer cell; DC = dendritic cell; Neu = neutrophil; ILT-2, -4 = inhibitory receptors Ig-like transcripts; KIR2DL4 = killer cell Ig-like receptor.

Alleles and proteins of HLA class I molecules[8]_

HLA-Ia molecules
GeneABCEFG
Alleles7,5629,0007,51331156104
Proteins4,3995,4144,1571211135
Nulls392312324805
DOI: https://doi.org/10.2478/fco-2022-0008 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
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Language: English
Page range: 53 - 62
Submitted on: Sep 20, 2022
Accepted on: Jan 9, 2023
Published on: Aug 3, 2023
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 times per year
Keywords:
Non-classical HLA molecules,
HLA-E, HLA-F, HLA-G,
immune modulation,
cancer,
tumour microenvironment
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology

© 2023 Anastasia Ormandjieva, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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