Table 1:
Alleles and proteins of HLA class I molecules[8].
| HLA-Ia molecules | ||||||
|---|---|---|---|---|---|---|
| Gene | A | B | C | E | F | G |
| Alleles | 7,562 | 9,000 | 7,513 | 311 | 56 | 104 |
| Proteins | 4,399 | 5,414 | 4,157 | 121 | 11 | 35 |
| Nulls | 392 | 312 | 324 | 8 | 0 | 5 |
Figure 1:
Structure of the HLA-E, -F, and -G genes.
Figure 2:
HLA-E expressed on a tumour cell, interacting with immune cells. Note: CD8+ = T cytotoxic cell; NK = natural killer cell.
Figure 3:
HLA-F expressed on a tumour cell, interacting with NK and T cell receptors. Note: NK = natural killer cell; KIR3DL2 = Killer cell Immunoglobulin Like Receptor; ILT-2, -4 = inhibitory receptors Ig-like transcripts.
Figure 4:
HLA-G expressed on a tumour cell, interacting with immune cell receptors. Note: CD8+ = T cytotoxic cell; CD4+ = T helper cell; Treg = T regulatory cell; NK = natural killer cell; DC = dendritic cell; Neu = neutrophil; ILT-2, -4 = inhibitory receptors Ig-like transcripts; KIR2DL4 = killer cell Ig-like receptor.