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Retroperitoneal pararenal dedifferentiated liposarcoma with epithelioid/neuroendocrine features, somatostatin-positive. Cover

Retroperitoneal pararenal dedifferentiated liposarcoma with epithelioid/neuroendocrine features, somatostatin-positive.

Forum of Clinical Oncology
Volume 13 (2022): Issue 1 (December 2022)
By:
Open Access
|Aug 2023

Figures & Tables

Figure 1:

Photomicrographs of liposarcoma with epithelioid/neuroendocrine dedifferentiation: A) histological view of a neoplasm organised in nests separated by thin fibrovascular branches, cytologically of epithelioid appearance (Hematoxilin and Eosin, 20×); B) at higher magnification, spindle/elongated neoplastic elements, also with mitosis (arrow), are observed at the edges of the epithelioid neoplasm, suggesting a possible mesenchymal origin (Hematoxilin and Eosin, 40×); C) immunohistochemistry for NSE, showing positivity in scattered neoplastic cells (10×); D) immunohistochemistry for somatostatin, showing ‹dot like› positivity in epithelioid neoplastic cells (10×).
Photomicrographs of liposarcoma with epithelioid/neuroendocrine dedifferentiation: A) histological view of a neoplasm organised in nests separated by thin fibrovascular branches, cytologically of epithelioid appearance (Hematoxilin and Eosin, 20×); B) at higher magnification, spindle/elongated neoplastic elements, also with mitosis (arrow), are observed at the edges of the epithelioid neoplasm, suggesting a possible mesenchymal origin (Hematoxilin and Eosin, 40×); C) immunohistochemistry for NSE, showing positivity in scattered neoplastic cells (10×); D) immunohistochemistry for somatostatin, showing ‹dot like› positivity in epithelioid neoplastic cells (10×).

Figure 2:

FISH photomicrograph showing a liposarcoma tissue section with amplification of the MDM2 gene (green signal), compared to the control CEN 12 (orange signal).
FISH photomicrograph showing a liposarcoma tissue section with amplification of the MDM2 gene (green signal), compared to the control CEN 12 (orange signal).
DOI: https://doi.org/10.2478/fco-2022-0007 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
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Language: English
Page range: 63 - 65
Submitted on: Nov 13, 2022
Accepted on: Jan 4, 2023
Published on: Aug 3, 2023
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 times per year
Keywords:
liposarcoma,
dedifferentiated,
epithelioid,
neuroendocrine,
somatostatin,
MDM2
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology

© 2023 Gabriele Gaggero, Paola Bet, Davide Taietti, Marta Ingaliso, Bruno Spina, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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