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Figure 5
Two-year survival multivariate analysis_
| Variable | HR | 95% CI | p value | R2 |
|---|---|---|---|---|
| Tumor location | 1.048 | 0.918–1.196 | 0.489 | 0.188 |
| T stage | 1.749 | 1.261–2.425 | 0.001 | |
| N stage | 1.212 | 0.997–1.474 | 0.049 | |
| Clinical stage | 1.749 | 1.261–2.425 | 0.001 |
Bivariate analysis of prognostic factors for one-year survival_
| Prognostic factor | Event (+) | OS | p value |
|---|---|---|---|
| Age | |||
| - ≤50 years old | 50 (66.6) | 25 (33.4) | 0.448 |
| - >50 years old | 64 (68) | 30 (32) | |
| Gender | |||
| - Male | 61 (70.1) | 26 (29.9) | 0.396 |
| - Female | 53 (64.6) | 29 (35.4) | |
| Tumor location | |||
| - Tongue | 81 (65.8) | 42 (34.2) | |
| - Buccal mucosa | 16 (72.8) | 6 (27.2) | 0.121 |
| - Mandible-maxilla | 13 (81.2) | 3 (18.8) | |
| - Palate | 4 (80) | 1 (20) | |
| - Gingiva | 0 (0) | 3 (100) | |
| T stage | |||
| - T1 | 1 (33.3) | 2 (66.7) | |
| - T2 | 4 (28.5) | 10 (71.5) | 0.006 |
| - T3 | 6 (46.1) | 7 (53.9) | |
| - T4 | 103 (74.2) | 36 (25.8) | |
| N stage | |||
| - N0 | 35 (61.5) | 22 (38.5) | |
| - N1 | 29 (60.4) | 19 (39.6) | 0.034 |
| - N2 | 48 (78.7) | 13 (21.3) | |
| - N3 | 2 (66.7) | 1 (33.3) | |
| Distant metastasis | |||
| - M0 | 106 (67) | 52 (33) | 0.490 |
| - M1 | 8 (72.7) | 3 (27.3) | |
| Clinical stage | |||
| - I | 1 (33.3) | 2 (66.7) | |
| - II | 4 (28.5) | 10 (71.5) | 0.006 |
| - III | 6 (46.1) | 7 (53.9) | |
| - IV | 103 (74.2) | 36 (25.8) | |
| Tumor differentiation | |||
| - Well differentiated | 66 (64.7) | 36 (35.3) | 0.810 |
| - Moderately differentiated | 30 (71.4) | 12 (28.6) | |
| - Poorly differentiated | 18 (72) | 7 (28) | |
| Tumor invasion (Bryne 1992) | |||
| - Low grade (Bryne score ≤8) | 61 (67) | 30 (33) | 0.773 |
| - High grade (Bryne score >8) | 53 (67.9) | 25 (32.1) | |
| Surgical margin | |||
| - Clear | 13 (33.3) | 26 (66.7) | 0.039 |
| - Involved | 3 (100) | 0 |
Bivariate analysis of prognostic factors for two-year survival_
| Prognostic factor | Event (+) | OS | p value |
|---|---|---|---|
| Age | |||
| - ≤50 years old | 62 (82.6) | 13 (17.4) | 0.637 |
| - >50 years old | 76 (80.8) | 18 (19.2) | |
| Gender | |||
| - Male | 73 (84) | 14 (16) | |
| - Female | 65 (79.3) | 17 (20.7) | 0.298 |
| Tumor location | |||
| - Tongue | 100 (81.3) | 23 (18.7) | |
| - Buccal mucosa | 19 (86.4) | 3 (13.6) | 0.069 |
| - Mandible-maxilla | 14 (87.5) | 2 (12.5) | |
| - Palate | 5 (100) | 0 (0) | |
| - Gingiva | 0 (0) | 3 (100) | |
| T stage | |||
| - T1 | 1 (33.4) | 2 (66.6) | |
| - T2 | 6 (42.9) | 8 (57.1) | 0.001 |
| - T3 | 9 (69.3) | 4 (30.7) | |
| - T4 | 122 (87.7) | 17 (12.3) | |
| N stage | |||
| - N0 | 43 (75.5) | 14 (24.5) | |
| - N1 | 37 (78) | 11 (22) | 0.014 |
| - N2 | 56 (91.9) | 5 (8,1) | |
| - N3 | 2 (66.6) | 1 (33.4) | |
| Distant metastasis | |||
| - M0 | 128 (81) | 30 (19) | 0.396 |
| - M1 | 10 (91) | 1 (9) | |
| Clinical stage | |||
| - I | 1 (33.4) | 2 (66.6) | |
| - II | 6 (42.8) | 8 (57.2) | 0.001 |
| - III | 9 (69.3) | 4 (30.7) | |
| - IV | 122 (87.8) | 17 (12.2) | |
| Tumor differentiation | |||
| - Well differentiated | 83 (81.4) | 19 (18.6) | 0.833 |
| - Moderately differentiated | 36 (85.7) | 6 (14.3) | |
| - Poorly differentiated | 19 (76) | 6 (24) | |
| Tumor invasion (Bryne 1992) | |||
| - Low grade (Bryne score ≤8) | 75 (82.4) | 16 (17.6) | 0.646 |
| - High grade (Bryne score >8) | 63 (80.8) | 15 (19.2) | |
| Surgical margin | |||
| - Clear | 21 (53.8) | 18 (46.2) | 0.039 |
| - Involved | 3 (100) | 0 |
Baseline characteristics of OSCC patients in Surgical Oncology Division, Department of Surgery from 2014 to 2018_
| Characteristic | N | % |
|---|---|---|
| Age | ||
| - ≤50 years old | 75 | 44.4 |
| - >50 years old | 94 | 55.6 |
| Gender | ||
| - Male | 87 | 51.5 |
| - Female | 82 | 48.5 |
| Tumor location | ||
| - Tongue | 123 | 72.8 |
| - Buccal mucosa | 22 | 13.0 |
| - Mandible-maxilla | 16 | 9.4 |
| - Palate | 5 | 3.0 |
| - Gingiva | 3 | 1.8 |
| T stage | ||
| - T1 | 3 | 1.8 |
| - T2 | 14 | 8.3 |
| - T3 | 13 | 7.7 |
| - T4 | 139 | 82.2 |
| N stage | ||
| - N0 | 57 | 33.7 |
| - N1 | 48 | 28.4 |
| - N2 | 61 | 36.1 |
| - N3 | 3 | 1.8 |
| Distant metastasis (M) | ||
| - 0 | 158 | 93.5 |
| - 1 | 11 | 6.5 |
| Clinical stage | ||
| - I | 3 | 1.8 |
| - II | 14 | 8.3 |
| - III | 13 | 7.7 |
| - IV | 139 | 82.2 |
| Keratinization | ||
| - Keratin | 140 | 82.8 |
| - Non keratin | 29 | 17.2 |
| Tumor differentiation | ||
| - Well differentiated | 102 | 60.4 |
| - Moderately differentiated | 42 | 24.9 |
| - Poorly differentiated | 25 | 14.8 |
| Tumor invasion (Bryne 1992) | ||
| - Low grade (Bryne score ≤8) | 91 | 53.8 |
| - High grade (Bryne score >8) | 78 | 46.2 |
| Surgical margin | ||
| - Clear | 39 | 92.9 |
| - Involved | 3 | 7.1 |
One-year survival multivariate analysis_
| Variable | HR | 95% CI | p value | R2 |
|---|---|---|---|---|
| Tumor location | 1.077 | 0.93–1.24 | 0.294 | 0.137 |
| T stage | 1.730 | 1.17–2.54 | 0.005 | |
| N stage | 1.231 | 0.99–1.52 | 0.055 | |
| Clinical stage | 1.730 | 1.17–2.54 | 0.005 |