Concentration of circulating tumour DNA in patients with metastatic gastric cancer and its prognostic significance

E. Karamitrousis; I. Balgkouranidou; N. Xenidis; K. Amarantidis; E. Biziota; T. Koukaki; S. Kakolyris

doi:10.2478/fco-2021-0010

.blurhash-client-img { display: none !important; }

Concentration of circulating tumour DNA in patients with metastatic gastric cancer and its prognostic significance

Forum of Clinical Oncology

Volume 12 (2021): Issue 3 (December 2021)

By: E. Karamitrousis, I. Balgkouranidou, N. Xenidis, K. Amarantidis, E. Biziota, T. Koukaki and S. Kakolyris

Open Access

|May 2022

Abstract

Gastric cancer is one of the most common cancers worldwide. The amount of cell-free DNA (cfDNA) in the blood of patients with gastric cancer was found to be higher than that of healthy controls (69.1 ng/μL vs. 34.8 ng/μL). Patients with cfDNA ≤ 50 ng/μL were found to have an increased overall survival (OS) and progression free survival (PFS) than in patients with cfDNA > 50 ng/μL.

References

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011 Apr;61(2):69–90.
Search in Google Scholar Back to article
Siegel, RL, Miller, KD, Fuchs, H, Jemal, A. Cancer Statistics, 2021. CA Cancer J Clin. 2021: 71: 7–33. https://doi.org/10.3322/caac.21654.
Search in Google Scholar Back to article
Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Kosary CL, et al. (eds). SEER cancer statistics review, 1975–2014, National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/csr/1975_2014/, based on November 2016 SEER data submission, posted to the SEER web site, April 2017.
Search in Google Scholar Back to article
Bertuccio P, Rosato V, Andreano A, Ferraroni M, Decarli A, Edefonti V, et al. Dietary patterns and gastric cancer risk: a systematic review and meta-analysis. Ann Oncol Off J Eur Soc Med Oncol. 2013 Jun;24(6):1,450–8.
Search in Google Scholar Back to article
Ma J-L, Zhang L, Brown LM, Li J-Y, Shen L, Pan K-F, et al. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst. 2012 Mar 21;104(6):488–92.
Search in Google Scholar Back to article
Fuccio L, Zagari RM, Eusebi LH, Laterza L, Cennamo V, Ceroni L, et al. Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer? Ann Intern Med. 2009 Jul 21;151(2):121–8.
Search in Google Scholar Back to article
Alix-Panabières C, Schwarzenbach H, Pantel K. Circulating tumor cells and circulating tumor DNA. Annu Rev Med. 2012;63:199–215.
Search in Google Scholar Back to article
Kohler C, Barekati Z, Radpour R, Zhong XY. Cell-free DNA in the circulation as a potential cancer biomarker. Anticancer Res. 2011 Aug;31(8):2,623–8.
Search in Google Scholar Back to article
Jin H, Ma Y, Shen Q, Wang X. Circulating methylated DNA as biomarkers for cancer detection. Methylation – DNA RNA Histones Dis Treat [Internet]. 2012 Nov 28 [cited 2019 May 4]; Available from: https://www.intechopen.com/books/methylation-from-dna-rna-and-histones-to-diseases-and-treatment/circulating-methylated-dna-as-biomarkers-for-cancer-detection.
Search in Google Scholar Back to article
Alix-Panabieres, C., Schwarzenbach, H., & Pantel, K.. Circulating tumor cells and circulating tumor DNA. Annu Rev Med, 2012;63,199–215.
Search in Google Scholar Back to article
Ghossein, RA, Bhattacharya, S, Rosai, J. Molecular detection of micrometastases and circulating tumor cells in solid tumors. Clin Cancer Res. 1999;5:1,950–1,960.
Search in Google Scholar Back to article
Mocellin, S., Keilholz, U., Rossi, C. R., Nitti, D. Circulating tumor cells: the ‘leukemic phase’ of solid cancers. Trends Mol Med. 2006;12:130–139.
Search in Google Scholar Back to article
Chimonidou, M., Strati, A., Tzitzira, A., Sotiropoulou, G., Malamos, N., Georgoulias, V., et al. DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells. Clin Chem. 2011;57:1,169–1,177.
Search in Google Scholar Back to article
Kohler, C., Barekati, Z., Radpour, R., Zhong, X. Y. Cell-free DNA in the circulation as a potential cancer biomarker. Anticancer Res. 2011;31:2,623–2,628.
Search in Google Scholar Back to article
Jin H, Ma Y, Shen Q, Wang X. Circulating methylated DNA as biomarkers for cancer detection. Methylation – DNA RNA Histones Dis Treat [Internet]. 2012 November 28 [cited 2019 May 4]; Available from: https://www.intechopen.com/books/methylation-from-dna-rna-and-histones-to-diseases-and-treatment/circulating-methylated-dna-as-biomarkers-for-cancer-detection.
Search in Google Scholar Back to article
Chen H-M, Fang J-Y. Epigenetic biomarkers for the early detection of gastrointestinal cancer. Gastrointest Tumors. 2014 May;1(4):201–8.
Search in Google Scholar Back to article
Karamitrousis EI, Balgkouranidou I, Xenidis N, Amarantidis K, Biziota E, Koukaki T, et al. Prognostic role of RASSF1A, SOX17 and Wif-1 promoter methylation status in cell-free DNA of advanced gastric cancer patients. Technol Cancer Res Treat. 2021 Jan–Dec;20:1533033820973279. doi: 10.1177/1533033820973279. PMID: 33928818; PMCID: PMC8113658.
Open DOI Search in Google Scholar Back to article
Balgkouranidou I, Matthaios D, Karayiannakis A, Bolanaki H, Michailidis P, Xenidis N, et al. Prognostic role of APC and RASSF1A promoter methylation status in cell free circulating DNA of operable gastric cancer patients. Mutat Res. 2015 Aug;778:46–51.
Search in Google Scholar Back to article
Bu J, Lee TH, Jeong WJ, Poellmann MJ, Mudd K, Eun HS, et al. Enhanced detection of cell-free DNA (cfDNA) enables its use as a reliable biomarker for diagnosis and prognosis of gastric cancer. PLoS One. 2020 Dec 2;15(12):e0242145. doi: 10.1371/journal.pone.0242145. PMID: 33264292; PMCID: PMC7710035.
Open DOI Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.2478/fco-2021-0010 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X

Journal RSS Feed

Language: English

Page range: 72 - 76

Submitted on: Oct 14, 2021

Accepted on: Dec 23, 2021

Published on: May 7, 2022

Published by: Helenic Society of Medical Oncology

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

Keywords:

Related subjects:

Haematology, oncology

© 2022 E. Karamitrousis, I. Balgkouranidou, N. Xenidis, K. Amarantidis, E. Biziota, T. Koukaki, S. Kakolyris, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 12 (2021): Issue 3 (December 2021)