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Sialic acids: An Avenue to Target Cancer Progression, Metastasis, and Resistance to Therapy Cover

Sialic acids: An Avenue to Target Cancer Progression, Metastasis, and Resistance to Therapy

Forum of Clinical Oncology
Volume 12 (2021): Issue 3 (December 2021)
By:
Open Access
|Apr 2022

Figures & Tables

Figure 1

In cancer cells, factors such as oncogenes, hormones, and therapy increase the expression of sialyltransferases while decreasing the expression of sialidases (Neu). As a result, sialoglycan synthesis by sialyltransferases in the Golgi system is increased, while sialoglycan hydrolysis by sialidases in the lysosome is decreased, resulting in the accumulation of hyposialylated structures on the cell membrane. The Fas receptor’s apoptotic signalling is impaired by unusually elevated sialoglycan expression (A). The integrins hypersialylation facilitates binding to the extracellular matrix (ECM) or selectins, allowing migration/tissue invasion and metastasis formation (C), and assisting immune evasion in cancer (B) and mediating resistance to therapy (D).
In cancer cells, factors such as oncogenes, hormones, and therapy increase the expression of sialyltransferases while decreasing the expression of sialidases (Neu). As a result, sialoglycan synthesis by sialyltransferases in the Golgi system is increased, while sialoglycan hydrolysis by sialidases in the lysosome is decreased, resulting in the accumulation of hyposialylated structures on the cell membrane. The Fas receptor’s apoptotic signalling is impaired by unusually elevated sialoglycan expression (A). The integrins hypersialylation facilitates binding to the extracellular matrix (ECM) or selectins, allowing migration/tissue invasion and metastasis formation (C), and assisting immune evasion in cancer (B) and mediating resistance to therapy (D).
DOI: https://doi.org/10.2478/fco-2021-0006 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
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Language: English
Page range: 40 - 48
Submitted on: Jul 9, 2021
Accepted on: Sep 15, 2021
Published on: Apr 19, 2022
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 times per year
Keywords:
chemoresistance,
immune evasion,
metastasis,
sialic acids,
tumorigenesis
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Haematology, oncology

© 2022 Mallikarjun Goni, Palaksha Kanive Javaregowda, Vishwanath Chachadi, DBM Virupakshaiah, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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