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A Review of Chemotherapy and Radiotherapy Near the End of Life in Individuals with Metastatic Non-small Cell Lung Cancer Cover

A Review of Chemotherapy and Radiotherapy Near the End of Life in Individuals with Metastatic Non-small Cell Lung Cancer

Open Access
|Sep 2020

Figures & Tables

Figure 1

Utilization of CHT and XRT. The percentage of patients that initiated chemotherapy and radiotherapy any time after diagnosis of Stage IV NSCLC is shown. Trends are shown in two-year time frames between 1995 and 2010.
Utilization of CHT and XRT. The percentage of patients that initiated chemotherapy and radiotherapy any time after diagnosis of Stage IV NSCLC is shown. Trends are shown in two-year time frames between 1995 and 2010.

Figure 2

Initiation of Treatments for Stage IV NSCLC in 60-Day Limited Survival. Only patients with a 60-day or less survival from date of diagnosis to date of death are included. The percentage of patients that initiated radiotherapy (red lines) and chemotherapy (blue lines) within each time frame after diagnosis of Stage IV NSCLC is shown: within 60 days of death, within 30 days of death, and within 14 days of death. Trends are shown in two-year time frames between 1995 and 2010.
Initiation of Treatments for Stage IV NSCLC in 60-Day Limited Survival. Only patients with a 60-day or less survival from date of diagnosis to date of death are included. The percentage of patients that initiated radiotherapy (red lines) and chemotherapy (blue lines) within each time frame after diagnosis of Stage IV NSCLC is shown: within 60 days of death, within 30 days of death, and within 14 days of death. Trends are shown in two-year time frames between 1995 and 2010.

Patient Characteristics_

CharacteristicDiagnosed PatientsCHT TreatmentXRT Treatment
Age at Diagnosis (years) ± quartiles60 69 76- -- -
Survival after Diagnosis (months)2.4 4.8 12.0--
Diagnosis to Treatment (months)-0.4 0.9 1.50.3 0.7 1.4
Treatment to Death (months)- -2.8 6.4 13.21.8 4.3 10.0
Male | Female58% | 42%58% | 42%60% | 40%
White | Non-White83% | 17%
% CHT Treated% XRT Treated
Patients Diagnosed 1995 to 2010N = 48,85844%44%
Treatment Before Death
  CHT and XRT11,983100%100%
  CHT and not XRT9,590100%0%
  XRT and not CHT9,6500%100%
  Neither17,6350%0%
Marital Status
  Married27,59249%46%
Widowed8,18032%36%
Single6,15242%45%
Divorced5,58644%47%
Unknown1,34838%46%
SES
Low6,90150%45%
Middle33,43044%44%
High8,52740%46%
Insurance Status
  Insured39,57544%43%
  Medicare26,30239%39%
  Private9,94755%48%
  Medicaid2,47648%52%
  Military89545%58%
Not insured2,44342%48%
Unknown6,84046%51%

Timing of treatment initiation in Stage IV NSCLC Patients from 1995 – 2010_

Years:95–9697–9899–0001–0203–0405–0607–0809–10Total
Patients who initiated first course of radiotherapy
> 60 days from death72.9%73.9%72.3%72.6%73.4%72.9%72.3%76.3%73.3%
31–60 days from death14.0%12.9%15.1%14.3%13.2%14.0%14.7%12.6%13.8%
15–30 days from death7.3%8.3%7.4%7.8%7.9%7.5%7.9%7.0%7.7%
0–14 days from death5.8%5.0%5.1%5.3%5.6%5.6%5.1%4.0%5.2%
Patients who initiated first course of chemotherapy
> 60 days from death81.6%82.7%82.7%82.6%83.4%84.0%83.7%85.2%83.3%
31–60 days from death9.2%8.3%9.0%9.5%8.7%8.5%8.8%7.7%8.1%
15–30 days from death5.2%5.3%5.1%4.5%4.1%4.8%4.4%3.9%5.0%
0–14 days from death4.0%3.8%3.2%3.4%3.7%2.7%3.1%3.2%3.6%

Factors Impacting Utilization_

Radiotherapy Received
CharacteristicOR95% CIP (Wald statistics)
Age 70: 650.897(0.887, 0.908)< 0.0001
Low SES: Middle SES1.015(0.959, 1.074)
0.173
Low SES: High SES1.073(0.992, 1.160)
Not Married: Married0.938(0.896, 0.982)0.006
Not Insured: Insured0.852(0.721, 1.007)< 0.0001
Female: Male0.863(0.826, 0.903)< 0.0001
CHT Received-Yes: No0.593(0.567, 0.619)< 0.0001
Chemotherapy Received
CharacteristicOR95% CIP (Wald Statistics)
Age 70: 650.824(0.814, 0.834)< 0.0001
Low SES: Middle SES0.830(0.783, 0.880)
< 0.0001
Low SES: High SES0.681(0.629, 0.738)
Not Married: Married0.702(0.671, 0.736)< 0.0001
Not Insured: Insured0.678(0.572, 0.804)< 0.0001
Female: Male1.077(1.029, 1.127)0.001
XRT Received-Yes: No0.593(0.568, 0.620)< 0.0001
DOI: https://doi.org/10.2478/fco-2019-0013 | Journal eISSN: 1792-362X | Journal ISSN: 1792-345X
Language: English
Page range: 29 - 38
Submitted on: Jul 14, 2017
Accepted on: Nov 5, 2019
Published on: Sep 8, 2020
Published by: Helenic Society of Medical Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 2 issues per year

© 2020 Benjamin C. Li, Stephanie M. Perkins, Sharon E. Phillips, Sara F. Martin, Samantha Hsieh, Eric T. Shinohara, Mark J. Stavas, published by Helenic Society of Medical Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.