Figure 1
Figure 2
Patients and disease characteristics_
| Feature | Patients # | % | |
|---|---|---|---|
| Gender | 510 | 100 | |
| Male | 329 | 65 | |
| Female | 181 | 35 | |
| Tumor Location | |||
| Right Colon | 169 | 33 | |
| Left Colon | 215 | 42 | |
| Rectum | 126 | 25 | |
| Tumor Differentiation | |||
| Well/Moderate | 323 | 63 | |
| Undifferentiated | 112 | 22 | |
| Unknown | 74 | 14 | |
| Mucinous | Yes | 351 | 69 |
| No | 85 | 17 | |
| Unknown | 74 | 14 | |
| Metastatic sites | |||
| Liver | 379 | 74 | |
| Lung | 193 | 38 | |
| Peritoneum | 98 | 19 | |
| Mutation | |||
| Present | 244 | 48 | |
| Undetectable | 256 | 52 |
Correlation of RAS mutation with clinical and pathological characteristics_
| Feature No (%) | RAS mutation | p value | |||
|---|---|---|---|---|---|
| Total | Wild Type | Mutant | |||
| ≤ 70 years | 380 (75) | 203 (53.4) | 177 (46.6) | ||
| Age | > 70 years | 130 (25) | 63 (48.5) | 67 (51.5) | 0.360 |
| Low grade | 323 (74) | 159 (49.2) | 164 (50.8) | ||
| Tumor Differentiation | High grade | 112 (26) | 60 (53.6) | 52 (46.4) | 0.444 |
| Right | 169 (33) | 108 (63.9) | 61 (36.9) | ||
| Tumor Location | Left | 341 (67) | 136 (39.9) | 205 (77.1) | <0.001 |
| Yes | 85 (17) | 49 (57.6) | 36 (42.4) | ||
| Mucinous | No | 351 (83) | 173 (49.3) | 178 (50.7) | 0.187 |
| Male | 389 (65) | 148 (45) | 181(55) | ||
| Gender | Female | 181 (35) | 96 (53) | 85 (45) | 0.095 |