Clinical and biological implications of Hippo pathway dysregulation in sarcomas

Kyriazoglou, Anastasios; Zakopoulou, Roubini; Zagouri, Flora; Bamias, Aristotelis; Dimopoulos, Meletios Athanasios

doi:10.2478/fco-2018-0002

Abstract

Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors. The molecular elements of Hippo signaling include MST1/2 and LATS1/2 kinases which phosphorylate and regulate the activity of YAP and TAZ co-transcriptional activators. Hippo pathway cross-talks with several molecular pathways with known oncogenic function. In sarcomas Hippo signaling plays a pivotal role in tumorigenesis, evolution and resistance in chemotherapy regimens. Targeting Hippo pathway could potentially improve prognosis and outcome of sarcoma patients.

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Clinical and biological implications of Hippo pathway dysregulation in sarcomas

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