Cervical intraspinal extradural primitive neuroectodermal tumour in an adult

Gogou, Pinelopi V; Balafouta, Myrsini J; Gennatas, Constantinos S; Kondi-Paphiti, Agatha; Papacharalampous, Xenophon N.; Michalaki, Vasiliki; Kouvaris, John R

doi:10.2478/fco-2014-0001

Abstract

Intraspinal extradural primitive neuroectodermal tumours (PNET) represent a rare entity that almost always carry a poor prognosis. A recent literature research revealed only four cases reported in adults. The tumours have mainly thoracic and lumbar location. We report the only case with cervical location and with the longest survival. Urgent laminectomy was performed resulting in a rapid pain relief for the patient. The patient was followed up with craniospinal irradiation and several cycles of chemotherapy. The patient died due to dissemination of the disease 31 months after the diagnosis. Intraspinal PNET tumours have a rapidly progressive course, and there is no current consensus on the optimal therapeutic approach.

References

[1] Ambros IM, Ambros PF, Strehl S, Kovar H, Gadner H, Salzer-Kuntschik M. MCI2 is a specifc marker for Ewings sarcoma and perifera primitive neuroectodermal tumours. Cancer 1991; 67: 1886-189310.1002/1097-0142(19910401)67:7<1886::AID-CNCR2820670712>3.0.CO;2-U
Search in Google Scholar
[2] Dehner LP. Primitive neuroectodermal tumour and Ewing s sarcoma. Am J Surg Pathol 1993; 17:1-1310.1097/00000478-199301000-00001
Search in Google Scholar
[3] Deme S, Ang LC, Skaf G, Rowed DW. Primary intramedullary primitive neuroectodermal tumour of the spinal cord: case report and review of the literature. Neurosurgery 1997; 41: 1417-142010.1097/00006123-199712000-00040
Search in Google Scholar
[4] Kosnik EJ, Bosel C, Bay J, Sayers MP. Primitive neuroectederaml tumours of the central nervous system in the childeren. J Neurosurg 1978; 48:741-74610.3171/jns.1978.48.5.0741
Search in Google Scholar
[5] Smith DR, Hardman JM, Earle KM. Metastazing neuroectedermal tumours of the central nervous system. J Neurosurg 1969; 31:50-5810.3171/jns.1969.31.1.0050
Search in Google Scholar
[6] Sevick RJ, Johns RD, Curry BJ. Primary spinal neuroectodermal tumour with extraneural metastasis AJNR 1987;8:1151-1152
Search in Google Scholar
[7] Kaspers GJ, Kamphorst W, von de Graff M, van Alphen HA, Veerman AJ. Primary spinal epidural extraosseous Ewing sarcoma. Cancer.1991;68:648-65410.1002/1097-0142(19910801)68:3<648::AID-CNCR2820680335>3.0.CO;2-Q
Search in Google Scholar
[8] Musahl V, Rihn JA, Fumich FE, Kang JD. Sacral intraspinal extradural primitive neuroectodermal tumour: a case report. The Spine J 2008;8:1024-102910.1016/j.spinee.2007.04.001
Search in Google Scholar
[9] Hariyama K, Oba Y, Mastuda S, Tanaka K, Chuman H, Iwamoto Y. Primitive neuroectodermal tumour and extraskeletal Ewing sarcoma arising primarly around the spinal column. Spine 2003;28:408-41210.1097/01.BRS.0000085099.47800.DF
Search in Google Scholar
[10] Virani MJ, Jain S. Primary intraspinal primitive neuroectodermal tumor (PNET): a rare occurrences 2002;50:75-80
Search in Google Scholar
[11] Kumar R, Reddy S.J., Wani A.A., Pal L. Primary Spinal primitive neuroectodermal tumour: case series and review of the literature. 2006;43: 1-6
Search in Google Scholar
[12] Marwin C, Synowitz HJ, Kirches E, Kutz E, Dietzmann K, Weiss S. Primary primitive neuroectodermal tumor of the spinal cord: case report and review of the literature. Clin Neurol and Neuros.2002;104: 36-4010.1016/S0303-8467(01)00171-8
Search in Google Scholar
[13] Ozdemir N, Usta G, Minoglu M, Erbay AM, Berzigcioglu H, Tunakan M. Primary primitive neuroectodermal tumour of the lumbar extradural space. J Neurosurg Pediatrics 2008;2: 215-22110.3171/PED/2008/2/9/215
Search in Google Scholar
[14] Liu HM, Yang WC, Garcia RL, Noh JM, Malhotra V, Leeds NE. Intraspinal primitive neuroectodermal tumour arising from the sacral spinal nerve. J Comput Tomogr 1987;11: 350-35410.1016/0149-936X(87)90071-3
Search in Google Scholar
[15] Dorfmuller G, Wurtz FG, Umschaden HW, Kleinert R, Ambros PF. Intraspinal primitive neuroectodermal tumour; Report of two caese and review of the literature. Act Neurochir (Wien)1999;141:1169-117510.1007/s00701005041410592116
Search in Google Scholar
[16] Weber DC, Rutz HP, Lomax AJ, et al. First spinal axis segment irradiation with spot scanning proton beam delivered in the treatment of a lumbar primitive neuroectodetmal tumour. Case report and review of the literature. Clin Oncol. 2004;16:324-325
Search in Google Scholar
[17] Akai T, Iizuka H, Kadoya S, Nojima T, Kohno M. Primitive neuroectodermal tumour in the spinal epidural space-case report., Neurol Med Chir, 1998;38:508-51110.2176/nmc.38.5089780651
Search in Google Scholar
[18] He SS, Zhao J, Han KW, Hou TS, Nazakat H., Zhang S. Primitive neuroectodermal tumour of lumbar spine: case report. Chin Med J 2007;120(9):844-84610.1097/00029330-200705010-00021
Search in Google Scholar
[19] Balafouta M, Kouvaris J, Miliadou A, et al. Primitive neuroectodermal tumour in a 60-year-old man: a case report and review of the literature. The Brit J Radiol 2002;75:62-65
Search in Google Scholar
[20] Boden SD, Wiesel SW. Lumbar spine imaging: role in clinical decision making. J Am Acd Orthop Surg 1996;4:238-2410.5435/00124635-199609000-0000210797191
Search in Google Scholar

Cervical intraspinal extradural primitive neuroectodermal tumour in an adult

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