Correlation of triglyceride-glucose index, complement C5, and lipoprotein(a) with carotid intima-media thickness in thyroid dysfunction: A cross-sectional study

Heri-Nugroho; Nurdopo Baskoro; Charles Limantoro; Andreas Arie Setiawan; Anugrah Riansari; Risa Ardiani

doi:10.2478/enr-2026-0001

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Correlation of triglyceride-glucose index, complement C5, and lipoprotein(a) with carotid intima-media thickness in thyroid dysfunction: A cross-sectional study

Endocrine Regulations

Volume 60 (2026): Issue 1 (January 2026)

By: Heri-Nugroho, Nurdopo Baskoro, Charles Limantoro, Andreas Arie Setiawan, Anugrah Riansari and Risa Ardiani

Open Access

|Mar 2026

Abstract

Objective. Thyroid dysfunction is associated with metabolic disturbances and an increased risk of atherosclerosis. This cross-sectional study investigated the relationships between the triglyceride-glucose index (TyG index), complement C5, lipoprotein(a) (Lp(a)), and carotid intima-media thickness (cIMT).

Methods. Clinical data were collected, blood samples analyzed, and cIMT measured using high-resolution ultrasound in 54 participants with thyroid dysfunction (27 with hypothyroidism and 27 with hyperthyroidism).

Results. The study found a significant positive correlation between the TyG index and cIMT in both hypothyroid and hyperthyroid patients. Complement C5 levels were also positively correlated with cIMT. No significant association was found between Lp(a) and cIMT.

Discussion. These findings highlight the complex interplay between thyroid dysfunction, metabolic dysregulation, and vascular health emphasizing the need for comprehensive cardiovascular risk assessment and management in patients with thyroid disorders.

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Articles in this issue

DOI: https://doi.org/10.2478/enr-2026-0001 | Journal eISSN: 1336-0329 | Journal ISSN: 1210-0668

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Language: English

Page range: 1 - 11

Published on: Mar 24, 2026

Published by: Slovak Academy of Sciences, Institute of Experimental Endocrinology

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Keywords:

atherosclerosis,

carotid intima-media thickness,

triglyceride-glucose index

Related subjects:

Basic medical science,

Basic medical science, other,

Clinical medicine,

Internal medicine,

Endocrinology, diabetology

© 2026 Heri-Nugroho, Nurdopo Baskoro, Charles Limantoro, Andreas Arie Setiawan, Anugrah Riansari, Risa Ardiani, published by Slovak Academy of Sciences, Institute of Experimental Endocrinology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 60 (2026): Issue 1 (January 2026)