Persistent chronic calcific pancreatitis with intraductal calculi associated with secondary diabetes mellitus type 3 and diabetic ketoacidosis – A case report

Gurusha Bahl; Dinesh K. Upadhyay; Madhumati Varma; Rajveer Singh; Subhankar Das; Sadique Hussain

doi:10.2478/enr-2024-0011

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Persistent chronic calcific pancreatitis with intraductal calculi associated with secondary diabetes mellitus type 3 and diabetic ketoacidosis – A case report

Endocrine Regulations

Volume 58 (2024): Issue 1 (January 2024)

By: Gurusha Bahl, Dinesh K. Upadhyay, Madhumati Varma, Rajveer Singh, Subhankar Das and Sadique Hussain

Open Access

|Apr 2024

Abstract

Diabetes mellitus type 3 refers to diabetes secondary to an existing disease or condition of the exocrine pancreas and is an uncommon cause of diabetes occurring due to pancreatogenic pathology. It accounts for 15–20% of diabetic patients in Indian and Southeast Asian continents. This is case report of a rare case of type 3 diabetes mellitus (T3DM) presenting with diabetic ketoacidosis (DKA). The patient was admitted for DKA along with complaint of hyperglycemia, blood glucose of 405 mg/dl with HbA1c level of 13.7%. Computed tomography evidence revealed chronic calcific pancreatitis with intraductal calculi and dilated pancreatic duct.

References

Alam S, Hasan MK, Neaz S, Hussain N, Hossain MF, Rahman T. Diabetes Mellitus: insights from epidemiology, biochemistry, risk factors, diagnosis, complications and comprehensive management. Diabetology 2, 36–50, 2021.
Search in Google Scholar Back to article
Bahl G, Upadhyay DK, Varma M, Singh R, Das S, Hussain MS. Chronic calcific pancreatitis presented with secondary diabetes and diabetic ketoacidosis: a case report. Clinical Diabetology 12(3), 209–211, 2023
Search in Google Scholar Back to article
Cui Y, Andersen DK. Pancreatogenic diabetes: special considerations for management. Pancreatology 11, 279–294, 2011.
Search in Google Scholar Back to article
Duggan SN, Ewald N, Kelleher L, Griffin O, Gibney J, Conlon KC. The nutritional management of type 3c (pancreatogenic) diabetes in chronic pancreatitis. Eur J Clin Nutr 71, 3–8, 2017.
Search in Google Scholar Back to article
Ebert R, Creutzfeldt W. Reversal of impaired GIP and insulin secretion in patients with pancreatogenic steatorrhea following enzyme substitution. Diabetologia 19, 198–204, 1980.
Search in Google Scholar Back to article
Egan AM, Dinneen SF. What is diabetes? Medicine 47, 1–4, 2019.
Search in Google Scholar Back to article
Ewald N, Kaufmann C, Raspe A, Kloer HU, Bretzel RG, Hardt PD. Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c). Diabetes Metab Res Rev 28, 338–342, 2012.
Search in Google Scholar Back to article
Ewald N, Bretzel RG. Diabetes mellitus secondary to pancreatic diseases (Type 3c) – are we neglecting an important disease? Eur J Intern Med 24, 203–206, 2013.
Search in Google Scholar Back to article
Ewald N, Hardt PD. Diagnosis and treatment of diabetes mellitus in chronic pancreatitis. World J Gastroenterol 19, 7276–7281, 2013.
Search in Google Scholar Back to article
Hardt PD, Brendel MD, Kloer HU, Bretzel RG. Is pancreatic diabetes (type 3c diabetes) underdiagnosed and misdiagnosed? Diabetes care 31, S165–S169, 2008.
Search in Google Scholar Back to article
Hart PA, Bellin MD, Andersen DK, Bradley D, Cruz-Monserrate Z, Forsmark CE, Goodarzi MO, Habtezion A, Korc M, Kudva YC, Pandol SJ. Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer. Lancet Gastroenterol Hepatol 1, 226–237, 2016.
Search in Google Scholar Back to article
Hart PA, Bradley D, Conwell DL, Dungan K, Krishna SG, Wyne K, Bellin MD, Yadav D, Andersen DK, Serrano J, Papachristou GI. Diabetes following acute pancreatitis. Lancet Gastroenterol Hepatol 6, 668–675, 2021.
Search in Google Scholar Back to article
Hussain MS, Sharma G. The Burden of Cardiovascular Diseases due to COVID-19 pandemic. The Thoracic and Cardiovascular Surgeon 70, 2022.
Search in Google Scholar Back to article
Kamat R, Gupta P, Rana S. Imaging in chronic pancreatitis: State of the art review. Indian J Radiol Imaging 29, 201–210, 2019.
Search in Google Scholar Back to article
Kulkarni CB, Sekhar R, Moorthy S, Pullara SK, Prabhu NK, Kannan RR. Imaging of tropical chronic pancreatitis – a unique clinico-radiological entity. J Gastrointestinal Abdominal Radiol 3, 144–152, 2020.
Search in Google Scholar Back to article
Kumari R, Kaur J, Hussain S. Management of diabetes with Covid-19: A review. Int J Pharm Pharm Sci 12, 1–6, 2020.
Search in Google Scholar Back to article
Melki G, Laham L, Karim G, Komal F, Kumar V, Barham S, Grossman M, Kuru S, Mohamed H, Garris R, Baddoura W. Chronic pancreatitis leading to pancreatogenic diabetes presenting in diabetic ketoacidosis: a rare entity. Gastroenterol Res 12, 208–210, 2019.
Search in Google Scholar Back to article
Sanyal D, Bhattacharjee K. Characteristics of children and adolescents with newly diagnosed Fibrocalculous pancreatitis diabetes (FCPD) and type 1 diabetes: A study from Eastern India. Diabetes Metab Syndr 16, 102527, 2022.
Search in Google Scholar Back to article
Sasikala M, Talukdar R, Subramanyam C, Reddy DR. The enigma of type 3c diabetes in chronic pancreatitis. Pancreas Open J 1, 19–21, 2016.
Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.2478/enr-2024-0011 | Journal eISSN: 1336-0329 | Journal ISSN: 1210-0668

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Language: English

Page range: 101 - 104

Published on: Apr 24, 2024

Published by: Slovak Academy of Sciences, Institute of Experimental Endocrinology

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Keywords:

pancreatogenic diabetes mellitus,

type 3 diabetes mellitus,

diabetic ketoacidosis,

Related subjects:

Basic medical science,

Basic medical science, other,

Clinical medicine,

Internal medicine,

Endocrinology, diabetology

© 2024 Gurusha Bahl, Dinesh K. Upadhyay, Madhumati Varma, Rajveer Singh, Subhankar Das, Sadique Hussain, published by Slovak Academy of Sciences, Institute of Experimental Endocrinology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 58 (2024): Issue 1 (January 2024)