References
- Almanza A, Carlesso A, Chintha C, Creedican S, Doultsinos D, Leuzzi B, Luis A, McCarthy N, Montibeller L, More S, Papaioannou A, Puschel F, Sassano ML, Skoko J, Agostinis P, de Belleroche J, Eriksson LA, Fulda S, Gorman AM, Healy S, Kozlov A, Munoz-Pinedo C, Rehm M, Chevet E, Samali A. Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications. FEBS J 286, 241–278, 2019.10.1111/febs.14608
- Auf G, Jabouille A, Guerit S, Pineau R, Delugin M, Bouchecareilh M, Favereaux A, Maitre M, Gaiser T, von Deimling A, Czabanka M, Vajkoczy P, Chevet E, Bikfalvi A, Moenner M. A shift from an angiogenic to invasive phenotype induced in malignant glioma by inhibition of the unfolded protein response sensor IRE1. Proc Natl Acad Sci U S A 107, 15553–15558, 2010.10.1073/pnas.0914072107
- Auf G, Jabouille A, Delugin M, Guerit S, Pineau R, North S, Platonova N, Maitre M, Favereaux A, Vajkoczy P, Seno M, Bikfalvi A, Minchenko D, Minchenko O, Moenner M. High epiregulin expression in human U87 glioma cells relies on IRE1alpha and promotes autocrine growth through EGF receptor. BMC Cancer 13, 597, 2013.10.1186/1471-2407-13-597
- Bravo R, Parra V, Gatica D, Rodriguez AE, Torrealba N, Paredes F, Wang ZV, Zorzano A, Hill JA, Jaimovich E, Quest AF, Lavandero S. Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol 301, 215–290, 2013.10.1016/B978-0-12-407704-1.00005-1
- Brunetti D, Torsvik J, Dallabona C, Teixeira P, Sztromwasser P, Fernandez-Vizarra E, Cerutti R, Reyes A, Preziuso C, D’Amati G, Baruffini E, Goffrini P, Viscomi C, Ferrero I, Boman H, Telstad W, Johansson S, Glaser E, Knappskog PM, Zeviani M, Bindoff LA. Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration. EMBO Mol Med 8, 176–190, 2016.10.15252/emmm.201505894
- Chevet E, Hetz C, Samali A. Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. Cancer Discov 5, 586–597, 2015.10.1158/2159-8290.CD-14-1490
- Chow KM, Gakh O, Payne IC, Juliano MA, Juliano L, Isaya G, Hersh LB. Mammalian pitrilysin: substrate specificity and mitochondrial Targeting. Biochemistry 48, 2868–2877, 2009.10.1021/bi8016125
- da Costa IB, de Labio RW, Rasmussen LT, Viani GA, Chen E, Villares J, Turecki G, Smith MAC, Payao SLM. Change in INSR, APBA2 and IDE gene expressions in brains of Alzheimer’s disease patients. Curr Alzheimer Res 14, 760–765, 2017.10.2174/1567205014666170203100734
- Doultsinos D, Avril T, Lhomond S, Dejeans N, Guedat P, Chevet E. Control of the unfolded protein response in health and disease. SLAS Discov 22, 787–800, 2017.10.1177/2472555217701685
- Falkevall A, Alikhani N, Bhushan S, Pavlov PF, Busch K, Johnson KA, Eneqvist T, Tjernberg L, Ankarcrona M, Glaser E. Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP. J Biol Chem 281, 29096–29104, 2006.10.1074/jbc.M602532200
- Fernandez-de Frutos M, Galan-Chilet I, Goedeke L, Kim B, Pardo-Marques V, Perez-Garcia A, Herrero JI, Fernandez-Hernando C, Kim J, Ramirez CM. MicroRNA 7 impairs insulin signaling and regulates Aβ levels through posttranscriptional regulation of the insulin receptor substrate 2, insulin receptor, insulin-degrading enzyme, and liver X receptor pathway. Mol Cell Biol 39. pii: e00170–19, 2019.10.1128/MCB.00170-19
- Fernandez-Diaz CM, Merino B, Lopez-Acosta JF, Cidad P, de la Fuente MA, Lobaton CD, Moreno A, Leissring MA, Perdomo G, Cozar-Castellano I. Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity. Am J Physiol Endocrinol Metab 317, E805–E819, 2019.10.1152/ajpendo.00040.2019
- Garcia-Gonzalez P, Cabral-Miranda F, Hetz C, Osorio F. Interplay between the unfolded protein response and immune function in the development of neurodegenerative diseases. Front Immunol 9, 2541, 2018.10.3389/fimmu.2018.02541
- Gerakis Y, Hetz C. Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer’s disease. FEBS J 285, 995–1011, 2018.10.1111/febs.14332
- Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates Iii JR, Itkin-Ansari P, Volkmann N, Kaufman RJ. The IRE1α/ XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells. PLoS Biol 13, e1002277, 2015.10.1371/journal.pbio.1002277
- Hetz C, Chevet E, Harding HP. Targeting the unfolded protein response in disease. Nat Rev Drug Discov 12, 703–719, 2013.10.1038/nrd3976
- Hetz C, Axten JM, Patterson JB. Pharmacological targeting of the unfolded protein response for disease intervention. Nat Chem Biol 15, 764–775, 2019.10.1038/s41589-019-0326-2
- Hughes D, Mallucci GR. The unfolded protein response in neurodegenerative disorders – therapeutic modulation of the PERK pathway. FEBS J 286, 342–355, 2019.10.1111/febs.14422
- Kazkayasi I, Burul-Bozkurt N, Ismail MA, Merino-Serrais P, Pekiner C, Cedazo-Minguez A, Uma S. Insulin deprivation decreases insulin degrading enzyme levels in primary cultured cortical neurons and in the cerebral cortex of rats with streptozotocin-induced diabetes. Pharmacol Rep 70, 677–683, 2018.10.1016/j.pharep.2018.01.008
- King JV, Liang WG, Scherpelz KP, Schilling AB, Meredith SC, Tang WJ. Molecular basis of substrate recognition and degradation by human presequence protease. Structure 22, 996–1007, 2014.10.1016/j.str.2014.05.003
- Kulas JA, Franklin WF, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, Hendrix RD, Taglialatela G, Barger SW, Combs CK. Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues. Am J Physiol Endocrinol Metab 316, E106–E120, 2019.10.1152/ajpendo.00279.2018
- Kurochkin IV, Guarnera E, Wong JH, Eisenhaber F, Berezovsky IN. Toward allosterically increased catalytic activity of insulin-degrading enzyme against amyloid peptides. Biochemistry 56, 228–239, 2017.10.1021/acs.biochem.6b00783
- Lee J, Ozcan U. Unfolded protein response signaling and metabolic diseases. J Biol Chem 289, 1203–1211, 2014.10.1074/jbc.R113.534743
- Liu Z, Dai J, Shen H. Systematic analysis reveals long noncoding RNAs regulating neighboring transcription factors in human cancers. Biochim Biophys Acta Mol Basis Dis 1864, 2785–2792, 2018.10.1016/j.bbadis.2018.05.006
- Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jager R, Gorman AM, Samali A. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun 9, 3267, 2018.10.1038/s41467-018-05763-8
- Manie SN, Lebeau J, Chevet E. Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update. Am J Physiol Cell Physiol 307, C901–C907, 2014.10.1152/ajpcell.00292.2014
- Marciniak SJ. Endoplasmic reticulum stress: a key player in human disease. FEBS J 286, 228–231, 2019.10.1111/febs.14740
- Martinez A, Lopez N, Gonzalez C, Hetz C. Targeting of the unfolded protein response (UPR) as therapy for Parkinson’s disease. Biol Cell 111, 161–168, 2019.10.1111/boc.201800068
- McMahon M, Samali A, Chevet E. Regulation of the unfolded protein response by noncoding RNA. Am J Physiol Cell Physiol 313, C243–C254, 2017.10.1152/ajpcell.00293.2016
- Mercado G, Castillo V, Soto P, Lopez N, Axten JM, Sardi SP, Hoozemans JJM, Hetz C. Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson’s disease. Neurobiol Dis 112, 136–148, 2018.10.1016/j.nbd.2018.01.004
- Minchenko DO, Danilovskyi SV, Kryvdiuk IV, Bakalets TV, Lypova NM, Karbovskyi LL, Minchenko OH. Inhibition of ERN1 modifies the hypoxic regulation of the expression of TP53-related genes in U87 glioma cells. Endoplasm Reticul Stress Dis 1, 18–26, 2014.10.2478/ersc-2014-0001
- Minchenko DO, Kharkova AP, Tsymbal DO, Karbovskyi LL, Minchenko OH. Expression of insulin-like growth factor binding protein genes and its hypoxic regulation in U87 glioma cells depends on ERN1 mediated signaling pathway of endoplasmic reticulum stress. Endocr Regul 49, 73–83, 2015a.10.4149/endo_2015_02_73
- Minchenko DO, Tsymbal DO, Riabovol OO, Viletska YM, Lahanovska YO, Sliusar MY, Bezrodnyi BH, Minchenko OH. Hypoxic regulation of EDN1, EDNRA, EDNRB, and ECE1 gene expressions in IRE1 knockdown U87 glioma cells. Endocr Reg 53, 250–262, 2019.10.2478/enr-2019-0025
- Minchenko OH, Tsymbal DO, Minchenko DO, Kovalevska OV, Karbovskyi LL, Bikfalvi A. Inhibition of ERN1 signaling enzyme affects hypoxic regulation of the expression of E2F8, EPAS1, HOXC6, ATF3, TBX3 and FOXF1 genes in U87 glioma cells. Ukr Biochem J 87, 76–87, 2015b.10.15407/ubj87.02.076
- Minchenko OH, Tsymbal DO, Minchenko DO, Moenner M, Kovalevska OV, Lypova NM. Inhibition of kinase and endoribonuclease activity of ERN1/IRE1 affects expression of proliferation-related genes in U87 glioma cells. Endoplasm Reticul Stress Dis 2, 18–29, 2015c.10.1515/ersc-2015-0002
- Minchenko OH, Kryvdiuk IV, Minchenko DO, Riabovol OO, Halkin OV. Inhibition of IRE1 signaling affects expression of a subset genes encoding for TNF-related factors and receptors and modifies their hypoxic regulation in U87 glioma cells. Endoplasm Reticul Stress Dis 3, 1–15, 2016.10.1515/ersc-2016-0001
- Minchenko OH, Luzina OY, Hnatiuk OS, Minchenko DO, Garmash YA, Ratushna OO. Expression of tumor growth related genes in IRE1 knockdown U87 glioma cells: effect of hypoxia. Ukr Biochem J 89, 40–51, 2017.10.15407/ubj89.05.040
- Minchenko OH, Kharkova AP, Hnatiuk OS, Luzina OY, Kryvdiuk IV, Kuznetsova AY. ERN1 modifies effect of gluta-mine deprivation on tumor growth related factors expression in U87 glioma cells. Ukr Biochem J 90, 49–61, 2018a.10.15407/ubj90.03.049
- Minchenko OH, Tsymbal DO, Minchenko DO, Hnatiuk OS, Prylutskyy YI, Prylutska SV, Ritter U. Single-walled carbon nanotubes affect the expression of genes associated with immune response in normal human astrocytes. Toxicol In Vitro 52, 122–130, 2018b.10.1016/j.tiv.2018.06.011
- Moenner M, Pluquet O, Bouchecareilh M, Chevet E. Integrated endoplasmic reticulum stress responses in cancer. Cancer Res 67, 10631–10634, 2007.10.1158/0008-5472.CAN-07-1705
- Ohyagi Y, Miyoshi K, Nakamura N. Therapeutic strategies for Alzheimer’s disease in the view of diabetes mellitus. Adv Exp Med Biol 1128, 227–248, 2019.10.1007/978-981-13-3540-2_11
- Papaioannou A, Chevet E. Driving cancer tumorigenesis and metastasis through UPR signaling. Curr Top Microbiol Immunol 414, 159–192, 2018.10.1007/82_2017_36
- Pinho CM, Teixeira PF, Glaser E. Mitochondrial import and degradation of amyloid-β peptide. Biochim Biophys Acta 1837, 1069–1074, 2014.10.1016/j.bbabio.2014.02.007
- Pivovarova O, Gogebakan O, Pfeiffer AF, Rudovich N. Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells. Diabetologia 52, 1656–1664, 2009.10.1007/s00125-009-1350-7
- Pivovarova O, von Loeffelholz C, Ilkavets I, Sticht C, Zhuk S, Murahovschi V, Lukowski S, Docke S, Kriebel J, de las Heras Gala T, Malashicheva A, Kostareva A, Lock JF, Stockmann M, Grallert H, Gretz N, Dooley S, Pfeiffer AF, Rudovich N. Modulation of insulin degrading enzyme activity and liver cell proliferation. Cell Cycle 14, 2293–2300, 2015.10.1080/15384101.2015.1046647
- Pivovarova O, Hohn A, Grune T, Pfeiffer AF, Rudovich N. Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease? Ann Med 48, 614–624, 2016.Sandoval K, Umbaugh D, House A, Crider A, Witt K. Somatostatin receptor subtype-4 regulates mRNA expression of amyloid-beta degrading enzymes and microglia mediators of phagocytosis in brains of 3xTg-AD mice. Neurochem Res 44, 2670–268, 2019.10.1007/s11064-019-02890-6
- Semenza GL. A compendium of proteins that interact with HIF-1α. Exp Cell Res 356, 128–135, 2017.10.1016/j.yexcr.2017.03.041
- Smith-Carpenter JE, Alper BJ. Functional requirement for human pitrilysin metallopeptidase 1 arginine 183, mutated in amyloidogenic neuropathy. Protein Sci 27, 861–873, 2018.10.1002/pro.3380
- Sun RC, Denko NC. Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth. Cell Metab 19, 285–292, 2014.10.1016/j.cmet.2013.11.022
- Tang WJ. Targeting insulin-degrading enzyme to treat Type 2 Diabetes Mellitus. Trends Endocrinol Metab 27, 24–34, 2016.10.1016/j.tem.2015.11.003
- Tundo GR, Sbardella D, Ciaccio C, Grasso G, Gioia M, Coletta A, Polticelli F, Di Pierro D, Milardi D, Van Endert P, Marini S, Coletta M. Multiple functions of insulin-degrading enzyme: a metabolic crosslight? Crit Rev Biochem Mol Biol 52, 554–582, 2017.10.1080/10409238.2017.1337707
- Villa-Perez P, Merino B, Fernandez-Diaz CM, Cidad P, Lobaton CD, Moreno A, Muturi HT, Ghadieh HE, Najjar SM, Leissring MA, Cozar-Castellano I, Perdomo G. Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice. Metabolism 88, 1–11, 2018.10.1016/j.metabol.2018.08.001
- Wang M, Kaufman RJ. Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529, 326–335, 2016.10.1038/nature17041
- Womeldorff M, Gillespie D, Jensen RL. Hypoxia-inducible factor–1 and associated upstream and downstream proteins in the pathophysiology and management of glioblastoma. Neurosurg Focus 37, E8, 2014.10.3171/2014.9.FOCUS14496
- Yamamoto N, Ishikuro R, Tanida M, Suzuki K, Ikeda-Matsuo Y, Sobue K. Insulin-signaling pathway regulates the degradation of amyloid β-protein via astrocytes. Neuroscience 385, 227–236, 2018.10.1016/j.neuroscience.2018.06.018
- Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ. Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife 7, e33572, 2018.10.7554/eLife.33572
- Zhang S, Xiao T, Yu Y, Qiao Y, Xu Z, Geng J, Liang Y, Mei Y, Dong Q, Wang B, Wei J, Suo G. The extracellular matrix enriched with membrane metalloendopeptidase and insulin-degrading enzyme suppresses the deposition of amyloid-beta peptide in Alzheimer’s disease cell models. J Tissue Eng Regen Med 13, 1759–1769, 2019.10.1002/term.2906
- Zhao S, Cai J, Li J, Bao G, Li D, Li Y, Zhai X, Jiang C, Fan L. Bioinformatic profiling identifies a glucose-related risk signature for the malignancy of glioma and the survival of patients. Mol Neurobiol 54, 8203–8210, 2017.10.1007/s12035-016-0314-4
- Zingale GA, Bellia F, Ahmed IMM, Mielczarek P, Silberring J, Grasso G. IDE degrades Nociceptin/Orphanin FQ through an insulin regulated mechanism. Int J Mol Sci 20, E4447, 2019.10.3390/ijms20184447