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Homeobox B4 gene expression is upregulated by ghrelin through PI3-kinase signaling pathway in rat’s bone marrow stromal cells Cover

Homeobox B4 gene expression is upregulated by ghrelin through PI3-kinase signaling pathway in rat’s bone marrow stromal cells

Open Access
|May 2019

References

  1. Abdanipour A, Shahsavandi B, Dadkhah M, Alipour M, Feizi H. The antiapoptotic effect of ghrelin in the H2O2 treated Bone Marrow-derived Mesenchymal Stem cells of rat. J Zanjan Univ Med Sci Health Serv 25, 58–68, 2017.
  2. Abdanipour A, Shahsavandi B, Alipour M, Feizi H. Ghrelin upregulates HOXB4 gene expression in the rat BMSCs. Cell J 20, 183–187, 2018a.
  3. Abdanipour A, Dadkhah M, Alipour M, Feizi H. Effect of ghrelin on caspase 3 and Bcl2 gene expression in H2O2 treated rat’s bone marrow stromal cells. Adv Pharm Bull 8, 429–435, 2018b.10.15171/apb.2018.050
  4. Albarran-Zeckler RG, Smith RG. The ghrelin receptors (GHS-R1a and GHS-R1b). Endocr Dev 25, 5–15, 2013.10.1159/000346042
  5. Anthony BA, Link DC. Regulation of hematopoietic stem cells by bone marrow stromal cells. Trends Immunol 35, 32–37, 2014.10.1016/j.it.2013.10.00224210164
  6. Antonchuk J, Sauvageau G, Humphries RK. HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation. Exp Hemato 29, 1125–1134, 2001.10.1016/S0301-472X(01)00681-6
  7. Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 109, 39–45, 2002.10.1016/S0092-8674(02)00697-9
  8. Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubini A, Malan D, Baj G, Granata R, Broglio F, Papotti M, Surico N, Bussolino F, Isgaard J, Deghenghi R, Sinigaglia F, Prat M, Muccioli G, Ghigo E, Graziani A. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 159, 1029–1037, 2002.10.1083/jcb.200207165217398112486113
  9. Bi L, Wang G, Yang D, Li S, Liang B, Han Z. Effects of autologous bone marrow-derived stem cell mobilization on acute tubular necrosis and cell apoptosis in rats. Exp Ther Med 10, 851–856, 2015.2662240410.3892/etm.2015.2592453317926622404
  10. Bianco P, Riminucci M, Gronthos S, Robey PG. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19, 180–192, 2001.10.1634/stemcells.19-3-18011359943
  11. Chung H, Seo S, Moon M, Park S. Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivationinduced apoptosis in primary rat cortical neuronal cells. J Endocrinol 198, 511–521, 2008.10.1677/JOE-08-016018541646
  12. Chung H, Chung HY, Bae CW, Kim CJ, Park S. Ghrelin suppresses tunicamycinor thapsigargin-triggered endoplasmic reticulum stress-mediated apoptosis in primary cultured rat cortical neuronal cells. Endocr J 58, 409–420, 2011.2149040610.1507/endocrj.K10E-39621490406
  13. Chung H, Li E, Kim Y, Kim S, Park S. Multiple signaling pathways mediate ghrelin-induced proliferation of hippocampal neural stem cells. J Endocrinol 218, 49–59, 2013.10.1530/JOE-13-004523608221
  14. Daniels TR, Neacato II, Rodriguez JA, Pandha HS, Morgan R, Penichet ML. Disruption of HOX activity leads to cell death that canbe enhanced by the interference of iron uptake in malignant B cells. Leukemia 24, 1555–1565, 2010.10.1038/leu.2010.142374396520574452
  15. Forrester LM, Jackson M. Mechanism of action of HOXB4 on the hematopoietic differentiation of embryonic stem cells. Stem Cells 30, 379–385, 2012.10.1002/stem.103622267295
  16. Gan Y, Shi C, Inge L, Hibner M, Balducci J, Huang Y. Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells. Oncogene 29, 4947–4958, 2010.10.1038/onc.2010.2402056291320562913
  17. Han D, Huang W, Ma S, Chen J, Gao L, Liu T, Zhang R, Li X, Li C, Fan M, Chen Y, Cao F. Ghrelin improves functional survival of engrafted adipose-derived mesenchymal stem cells in ischemic heart through PI3K/Akt signaling pathway. Biomed Res Int 2015, 858349, 2015.10.1155/2015/858349438797625879037
  18. Hu X, Yu SP, Fraser JL, Lu Z, Ogle ME, Wang JA, Wei L. Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. J Thorac Cardiovasc Surg 135, 799–808, 2008.10.1016/j.jtcvs.2007.07.07118374759
  19. Hu C, Huang L, Gest C, Xi X, Janin A, Soria C, Li H, Lu H. Opposite regulation by PI3K/Akt and MAPK/ERK pathways of tissue factor expression, cell-associated procoagulant activity and invasiveness in MDA-MB-231 cells. J Hematol Oncol 5, 16, 2012.10.1186/1756-8722-5-16339422022534171
  20. Jackson M, Axton RA, Taylor AH, Wilson JA, Gordon-Keylock SA, Kokkaliaris KD, Brickman JM, Schulz H, Hummel O, Hubner N, Forrester LM. HOXB4 can enhance the differentiation of embryonic stem cells by modulating the hematopoietic niche. Stem Cells 30, 150–160, 2012.2208401610.1002/stem.78222084016
  21. Kanoski SE, Fortin SM, Ricks KM, Grill HJ. Ghrelin signaling in the ventral hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling. Biol Psychiatry 73, 915–923, 2013.10.1016/j.biopsych.2012.07.002349860022884970
  22. Kirito K, Fox N, Kaushansky K. Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells. Blood 102, 3172–3178, 2003.10.1182/blood-2003-03-09441285555512855555
  23. Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev 85, 495–522, 2005.10.1152/physrev.00012.200415788704
  24. Lee ER, Kim JY, Kang YJ, Ahn JY, Kim JH, Kim BW, Choi HY, Jeong MY, Cho SG. Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis. Biochim Biophys Acta 1763, 958–968, 2006.10.1016/j.bbamcr.2006.06.00616905201
  25. Lee GS, Kim BS, Sheih JH, Moore MA. Forced expression of HoxB4 enhances hematopoietic differentiation by human embryonic stem cells. Mol Cells 25, 487–493, 2008.1851188010.1016/S1016-8478(23)17609-6
  26. Li E, Chung H, Kim Y, Kim DH, Ryu JH, Sato T, Kojima M, Park S. Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory. Endocr J 60, 781–789, 2013.2341158510.1507/endocrj.EJ13-0008
  27. Mahmood A, Lu D, Chopp M. Marrow stromal cell transplantation after traumatic brain injury promotes cellular proliferation within the brain. Neurosurgery 55, 1185–1193, 2004.10.1227/01.NEU.0000141042.14476.3C15509325
  28. Moon M, Kim S, Hwang L, Park S. Ghrelin regulates hippocampal neurogenesis in adult mice. Endocrine J 56, 525–531, 2009.10.1507/endocrj.K09E-08919506321
  29. Murata M, Okimura Y, Iida K, Matsumoto M, Sowa H, Kaji H, Kojima M, Kangawa K, Chihara K. Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells. J Biol Chem 277, 5667–5674, 2002.10.1074/jbc.M10389820011724768
  30. Park SW, Won KJ, Lee YS, Kim HS, Kim YK, Lee HW, Kim B, Lee BH, Kim JH, Kim DK. Increased HoxB4 inhibits apoptotic cell death in Pro-B cells. Korean J Physiol Pharmacol 16, 265–271, 2012.Potier E, Ferreira E, Meunier A, Sedel L, Logeart-Avramoglou D, Petite H. Prolonged hypoxia concomitant with serum deprivation induces massive human mesenchymal stem cell death. Tissue Eng 13, 1325–1331, 2007.10.4196/kjpp.2012.16.4.265341976222915992
  31. Svingen T, Tonissen KF. Hox transcription factors and their elusive mammalian gene targets. Heredity 97, 88–96, 2006.10.1038/sj.hdy.68008471672138916721389
  32. Thorsteinsdottir U, Sauvageau G, Humphries RK. Enhanced in vivo regenerative potential of HOXB4-transduced hematopoietic stem cells with regulation of their pool size. Blood 94, 2605–2612, 1999.1051586410.1182/blood.V94.8.2605.420k19_2605_2612
  33. van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25, 426–457, 2004.10.1210/er.2002-002915180951
  34. Yang J, Liu GQ, Wei R, Hou WF, Gao MJ, Zhu MX, Wang HN, Chen GA, Hong TP. Ghrelin promotes differentiation of human embryonic stem cells into cardiomyocytes. Acta Pharmacol Sin 32, 1239–1245, 2011.10.1038/aps.2011.7921804576401007621804576
  35. Yin Y, Li Y, Zhang W. The growth hormone secretagogue receptor: its intracellular signaling and regulation. Int J Mol Sci 15, 4837–4855, 2014.10.3390/ijms1503483724651458397542724651458
DOI: https://doi.org/10.2478/enr-2019-0008 | Journal eISSN: 1336-0329 | Journal ISSN: 1210-0668
Language: English
Page range: 65 - 70
Published on: May 13, 2019
Published by: Slovak Academy of Sciences, Institute of Experimental Endocrinology
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:

© 2019 Shokoufeh Taherkhani, Fatemeh Moradi, Masoumeh Hosseini, Mohsen Alipour, Hadi Feizi, published by Slovak Academy of Sciences, Institute of Experimental Endocrinology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.