Have a personal or library account? Click to login
Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease Cover

Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease

Open Access
|Feb 2019

References

  1. Ali O. Genetics of type 2 diabetes. World J Diabetes 4,114–123, 2013.10.4239/wjd.v4.i4.114374608323961321
  2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 36, S67–S74, 2013.10.2337/dc13-S067353727323264425
  3. Assmann TS, Duarte GCK, Rheinheimer J, Cruz LA, Canani LH and Crispim D. The TCF7L2 rs7903146 (C/T) polymorphism is associated with risk to type 2 diabetes mellitus in Southern-Brazil. Arq Bras Endocrinol Metabol 58, 918–925, 2014.10.1590/0004-273000000351025627047
  4. Barros CMAR, Araujo-Neto AP, Lopes TR, Barros MAL, Motta FJN, Canalle R, Nunes LCC, Rey JA, Burbano RR, Lima-Barros MA, Yoshioka FK, Pinto GR. Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil. Genet Mol Res 13, 7889–7898, 2014.10.4238/2014.September.29.125299103
  5. Bielinski SJ, Pankow JS, Folsom AR, North KE and Boerwinkle E. TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study. Diabetologia 51, 968–970, 2008.10.1007/s00125-008-1004-1259720318437354
  6. Cauchi S, El Achhab Y, Choquet H, Dina C, Krempler F, Weitgasser R, Nejjari C, Patsch W, Chikri M, Meyre D, Froguel P. TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med 85, 777–782, 2007.10.1007/s00109-007-0203-417476472
  7. Chauhan G, Spurgeon CJ, Tabassum R, Bhaskar S, Kulkarni SR, Mahajan A, Chavali S, Kumar MV, Prakash S, Dwivedi OP, Ghosh S, Yajnik CS, Tandon N, Bharadwaj D, Chandak GR. Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes 59, 2068–2074, 2010.10.2337/db09-1386291105120424228
  8. Dawson K, Aflaki M, Nattel S. Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential. J Physiol 591, 1409–1432, 2013.10.1113/jphysiol.2012.235382360716323207593
  9. de Melo SF, Frigeri HR, dos Santos-Weiss ICR, Rea RR, de Souza EM, Alberton D, Gomes de Moraes Rego F, Picheth
  10. G. Polymorphisms in FTO and TCF7L2 genes of Euro-Brazilian women with gestational diabetes. Clin Biochem 48, 1064–1067, 2015.10.1016/j.clinbiochem.2015.06.01326102344
  11. Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38, 320–323, 2006.10.1038/ng173216415884
  12. Jin T. The WNT signalling pathway and diabetes mellitus. Diabetologia 51, 1771–1780, 2008.10.1007/s00125-008-1084-y1869604918696049
  13. Lahiri DK, Nurnberger JI Jr. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 19, 5444, 1991.10.1093/nar/19.19.544416815113289201681511
  14. Liu Z, Habener JF. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem 283, 8723–8735, 2008.10.1074/jbc.M706105200241716618216022
  15. Long J, Edwards T, Signorello LB, Cai Q, Zheng W, Shu XO, Blot WJ. Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans. Am J Epidemiol 176, 995–1001, 2012.10.1093/aje/kws176357124323144361
  16. Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjogren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117, 2155–2163, 2007.10.1172/JCI30706193459617671651
  17. MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17, 9–26, 2009.1961948810.1016/j.devcel.2009.06.016286148519619488
  18. Marquezine G, Pereira A, Sousa A, Mill J, Hueb W, Krieger J. TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population. BMC Med Genet 9, 106, 2008.10.1186/1471-2350-9-106263265919055834
  19. Muendlein A, Saely CH, Geller-Rhomberg S, Sonderegger G, Rein P, Winder T, Beer S, Vonbank A, Drexel H. Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis. PLoS One 6, e17978, 2011.10.1371/journal.pone.0017978305805921423583
  20. Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). J Biol Chem 287, 12016–12026, 2012.10.1074/jbc.M111.337048332094822337886
  21. Rulifson IC, Karnik SK, Heiser PW, ten Berge D, Chen H, Gu X, Taketo MM, Nusse R, Hebrok M, Kim SK. Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci 104, 6247–6252, 2007.10.1073/pnas.0701509104184745517404238
  22. Schafer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst JJ, Dekker JM, ‘t Hart LM, Nijpels G, van
  23. Haeften TW, Haring HU, Fritsche A. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 50, 2443–2450, 2007.10.1007/s00125-007-0753-6206356317661009
  24. Schinner S, Ulgen F, Papewalis C, Schott M, Woelk A, Vidal-Puig A, Scherbaum WA. Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia 51, 147–154, 2007.1799421710.1007/s00125-007-0848-017994217
  25. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316, 1341–1345, 2007.10.1126/science.1142382321461717463248
  26. Sousa AGP, Marquezine GF, Lemos PA, Martinez E, Lopes N, Hueb WA, Krieger JE, Pereira AC. TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality. PLoS One 4, e7697, 2009.10.1371/journal.pone.0007697277342519924244
  27. Szabo M, Mate B, Csep K, Benedek T. Genetic approaches to the study of gene variants and their impact on the patho-physiology of type 2 diabetes. Biochem Genet 56, 22–55, 2018.10.1007/s10528-017-9827-429143895
  28. Tong Y, Lin Y, Zhang Y, Yang J, Zhang Y, Liu H, Zhang B. Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis. BMC Med Genet 10, 15, 2009.10.1186/1471-2350-10-15265347619228405
  29. Travers ME, McCarthy MI. Type 2 diabetes and obesity: genomics and the clinic. Hum Genet 130, 41–58, 2011.10.1007/s00439-011-1023-821647602
  30. Turki A, Al-Zaben GS, Mtiraoui N, Marmmuoch H, Mahjoub T, Almawi WY. Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects. Gene 513, 244–248, 2013.10.1016/j.gene.2012.10.08623142382
  31. Wang J, Zhang J, Li L, Wang Y, Wang Q, Zhai Y, You H, Hu D. Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis. Brazilian J Med Biol Res 46, 382–393, 2013.10.1590/1414-431X20132677
  32. Weedon MN. The importance of TCF7L2. Diabet Med 24, 1062–1066, 2007.10.1111/j.1464-5491.2007.02258.x17888129
  33. Xavier HT, Izar MC, Faria Neto JR, Assad MH, Rocha VZ, Sposito AC, Fonseca FA, Santos JE dos, Santos RD, Bertolami MC, Faludi AA, Martinez TLR, Diament J, Guimaraes A, Forti NA, Moriguchi E, Chagas ACP, Coelho OR, Ramires JAF. V Diretriz Brasileira de Dislipidemias e Prevencao da Aterosclerose. Arq Bras Cardiol 101, 1–22, 2013.10.5935/abc.2013S01024217493
DOI: https://doi.org/10.2478/enr-2019-0001 | Journal eISSN: 1336-0329 | Journal ISSN: 1210-0668
Language: English
Page range: 1 - 7
Published on: Feb 23, 2019
Published by: Slovak Academy of Sciences, Mathematical Institute
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2019 Camile Wunsch, Thais Fernanda Dornelles, Pricila Girardi, Marcelo Emilio Arndt, Julia Pasqualini Genro, Veronica Contini, published by Slovak Academy of Sciences, Mathematical Institute
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.