Have a personal or library account? Click to login

High dose of histone deacetylase inhibitors affects insulin secretory mechanism of pancreatic beta cell line

By:
Open Access
|Feb 2018

References

  1. Bompada P, Atac D, Luan C, Andersson R, Omella JD, Laakso EO, Wright J, Groop L, De Marinis Y. Histone acetylation of glucose-induced thioredoxin-interacting protein gene expression in pancreatic islets. Int J Biochem Cell Biol 81, 82-91, 2016.10.1016/j.biocel.2016.10.022
  2. Butler LM, Zhou X, Xu WS, Scher HI, Rifk ind RA, Marks PA, Richon VM. Th e histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. Proc Natl Acad Sci U S A 99, 11700-11705, 2002.10.1073/pnas.182372299
  3. Cha-Molstad H, Saxena G, Chen J, Shalev A. Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells. J Biol Chem 284, 16898-16905, 2009.10.1074/jbc.M109.010504
  4. Christensen DP, Dahllof M, Lundh M, Rasmussen DN, Nielsen MD, Billestrup N, Grunnet LG, Mandrup-Poulsen T. Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Mol Med 17, 378-390, 2011.10.2119/molmed.2011.00021
  5. Fu J, Zhang Q, Woods CG, Zheng H, Yang B, Qu W, Andersen ME, Pi J. Divergent eff ects of sulforaphane on basal and glucose-stimulated insulin secretion in b-cells: role of reactive oxygen species and induction of endogenous antioxidants. Pharm Res 30, 2248-2259, 2013.10.1007/s11095-013-1013-8
  6. Halsall J, Gupta T, O’Neill LP, Turner BM, Nightingale KP. Genes are oft en sheltered from the global histone hyperacetylation induced by HDAC inhibitors. PLoS One 7, e33453, 2012.10.1371/journal.pone.0033453
  7. Hotta M, Tashiro F, Ikegami H, Niwa H, Ogihara T, Yodoi J, Miyazaki J. Pancreatic beta cell-specifi c expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes. J. Exp Med 188, 1445-1451, 1998.10.1084/jem.188.8.1445
  8. Junn E, Han SH, Im JY, Yang Y, Cho EW, Um HD, Kim DK, Lee KW, Han PL, Rhee SG, Choi I. Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol 164, 6287-95, 2000.10.4049/jimmunol.164.12.6287
  9. Khan S, Jena GB. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chem Biol Interact 213, 1-12, 2014.10.1016/j.cbi.2014.02.001
  10. Khan S, Jena G. Th e role of butyrate, a histone deacetylase inhibitor in diabetes mellitus: experimental evidence for therapeutic intervention. Epigenomics 7, 669-80, 2015.10.2217/epi.15.20
  11. Kubicek S, Gilbert JC, Fomina-Yadlin D, Gitlin AD, Yuan Y, Wagner FF, Holson EB, Luo T, Lewis TA, Taylo B, Gupta S, Shamji AF, Wagner BK, Clemons PA, Schreiber SL. Chromatin-targeting small molecules cause class-specifi c transcriptional changes in pancreatic endocrine cells. Proc Natl Acad Sci U S A 109, 5364-5369, 2012.10.1073/pnas.1201079109
  12. Larsen L, Tonnesen M, Ronn SG, Storling J, Jorgensen S, Mascagni P, Dinarello CA, Billestrup N, Mandrup-Poulsen T. Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells. Diabetologia 50, 779- 789, 2007.10.1007/s00125-006-0562-3
  13. Llanos P, Contreras-Ferrat A, Barrientos G, Valencia M, Mears D, Hidalgo C. Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors. PLoS One 10, e0129238, 2015.10.1371/journal.pone.0129238
  14. Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahllof MS, Skovgaard T, Berthelsen J, Dinarello CA, Stevenazzi A, Mascagni P, Grunnet G, Morgan NG, Mandrup-Poulsen T. Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are diff erentially regulated in the islets of type 1 diabetic children. Diabetologia 55, 2421-2431, 2012.10.1007/s00125-012-2615-0
  15. Lundh M, Galbo T, Poulsen SS, Mandrup-Poulsen T. Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats. Diabetes, Obes Metab 17, 703-707, 2015.10.1111/dom.12470
  16. Manal M, Chandrasekar MJN, Gomathi Priya J, Nanjan MJ. Inhibitors of histone deacetylase as antitumor agents: A critical review. Bioorg Chem 67, 18-42, 2016.10.1016/j.bioorg.2016.05.005
  17. Marks PA. Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions. Biochim Biophys Acta 1799, 717-725, 2010.10.1016/j.bbagrm.2010.05.008
  18. Minn AH, Hafele C, Shalev A. Th ioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis. Endocrinology 146, 2397-2405, 200510.1210/en.2004-1378
  19. Miyazaki J, Araki K, Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y, Yamamura K. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127, 126-32, 1990.10.1210/endo-127-1-126
  20. Newbold A, Falkenberg KJ, Prince HM, Johnstone RW. How do tumor cells respond to HDAC inhibition? FEBS J 283, 4032-4046, 2016.10.1111/febs.13746
  21. Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Reece, JM, Deeney JT, Andersen ME, Corkey BE, Collins S. Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes 56, 1783-1791, 2007.10.2337/db06-1601
  22. Plaisance V, Rolland L, Gmyr V, Annicotte JS, Kerr-Conte J, Pattou F, Abderrahmani A. Th e class I histone deacetylase inhibitor MS-275 prevents pancreatic beta cell death induced by palmitate. J Diabetes Res 2014, 195739, 2014.10.1155/2014/195739
  23. Saadeh M, Ferrante TC, Kane A, Shirihai O, Corkey BE, Deeney JT. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. PLoS One 7, e30200, 2012.10.1371/journal.pone.0030200
  24. Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem 279, 30369-30374, 2004.10.1074/jbc.M400549200
  25. Sharma S, Taliyan R. Histone deacetylase inhibitors: Future therapeutics for insulin resistance and type 2 diabetes. Pharmacol Res 113, 320-326, 2016.10.1016/j.phrs.2016.09.009
  26. Susick L, Veluthakal R, Suresh MV, Hadden T, Kowluru A. Regulatory roles for histone deacetylation in IL-1betainduced nitric oxide release in pancreatic beta-cells. J Cell Mol Med 12, 1571-1583, 2008.10.1111/j.1582-4934.2007.00171.x
  27. Tiernan AR, Champion JA, Sambanis A. Trichostatin A aff ects the secretion pathways of beta and intestinal endocrine cells. Exp Cell Res 330, 212-21, 2015.10.1016/j.yexcr.2014.09.031
  28. Ungerstedt J, Du Y, Zhang H, Nair D, Holmgren A. In vivo redox state of Human thioredoxin and redox shift by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). Free Radic Biol Med 53, 2002-2007, 2012.10.1016/j.freeradbiomed.2012.09.019
  29. Xu G, Chen J, Jing G, Shalev A. Th ioredoxin-interacting protein regulates insulin transcription through microRNA-204. Nat Med 19, 1141-1146, 2013.10.1038/nm.3287
  30. Yamamoto M, Yamato E, Toyoda S, Tashiro F, Ikegami H, Yodoi J, Miyazaki J. Transgenic expression of antioxidant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus. Antioxid Redox Signal 10, 43-49, 2008.10.1089/ars.2007.1586
  31. Yamato E, Tashiro F, Miyazaki J. Microarray analysis of novel candidate genes responsible for glucose-stimulated insulin secretion in mouse pancreatic β cell line MIN6. PLoS One 8, e61211, 2013.10.1371/journal.pone.0061211
  32. Zhang J, Zhong Q. Histone deacetylase inhibitors and cell death. Cell Mol Life Sci 71, 3885-901, 2014.10.1007/s00018-014-1656-6
DOI: https://doi.org/10.2478/enr-2018-0004 | Journal eISSN: 1336-0329 | Journal ISSN: 1210-0668
Language: English
Page range: 21 - 26
Published on: Feb 16, 2018
Published by: Slovak Academy of Sciences, Mathematical Institute
In partnership with: Paradigm Publishing Services
Publication frequency: 1 times per year

© 2018 Eiji Yamato, published by Slovak Academy of Sciences, Mathematical Institute
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.