Have a personal or library account? Click to login
Association of the 5HTR2C gene Ser23 variation with childhood allergic asthma Cover

Association of the 5HTR2C gene Ser23 variation with childhood allergic asthma

Open Access
|Jul 2022

References

  1. 1. Li J, Hashimoto H, Meltzer HY. Association of Serotonin2c Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia. Front Psychiatry 2019; 10: 58. Published 2019 Feb 15. DOI:10.3389/fpsyt.2019.00058638423530828307
  2. 2. Santana N, Artigas F. Laminar and Cellular Distribution of Monoamine Receptors in Rat Medial Prefrontal Cortex. Front Neuroanat. 2017;11:87. Published 2017 Sep 28. doi:10.3389/fnana.2017.00087562502829033796
  3. 3. Stamm S, Gruber SB, Rabchevsky AG, Emeson RB. The activity of the serotonin receptor 2C is regulated by alternative splicing. Hum Genet. 2017;136(9):1079-1091. DOI:10.1007/s00439-017-1826-3587358528664341
  4. 4. Heisler LK, Pronchuk N, Nonogaki K, et al. Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J Neurosci. 2007;27(26):6956-6964. doi:10.1523/JNEUROSCI.2584-06.2007667223817596444
  5. 5. Lappalainen J, Zhang L, Dean M, et al. Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). Genomics. 1995;27(2):274-279. doi:10.1006/geno.1995.10427557992
  6. 6. Holmes C, Arranz MJ, Powell JF, Collier DA, Lovestone S. 5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer’s disease. Hum Mol Genet. 1998;7(9):1507-1509. doi:10.1093/hmg/7.9.15079700207
  7. 7. Holmes C, Arranz M, Collier D, Powell J, Lovestone S. Depression in Alzheimer’s disease: the effect of serotonin receptor gene variation. Am J Med Genet B Neuropsychiatr Genet. 2003;119B(1):40-43. doi:10.1002/ajmg.b.1006812707936
  8. 8. Brummett BH, Kuhn CM, Boyle SH, Babyak MA, Siegler IC, Williams RB. Cortisol responses to emotional stress in men: association with a functional polymorphism in the 5HTR2C gene. Biol Psychol. 2012;89(1):94-98. doi:10.1016/j.biopsycho.2011.09.013324575121967853
  9. 9. Brummett BH, Babyak MA, Jiang R, et al. A functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events. PLoS One. 2013;8(12):e82781. Published 2013 Dec 18. doi:10.1371/journal.pone.0082781386739324386118
  10. 10. Rosenberg SL, Miller GE, Brehm JM, Celedón JC. Stress and asthma: novel insights on genetic, epigenetic, and immunologic mechanisms. J Allergy Clin Immunol. 2014;134(5):1009-1015. doi:10.1016/j.jaci.2014.07.005425239225129683
  11. 11. Potaczek DP, Harb H, Michel S, Alhamwe BA, Renz H, Tost J. Epigenetics and allergy: from basic mechanisms to clinical applications. Epigenomics 2017;9(4):539-571. DOI:10.2217/epi-2016-016228322581
  12. 12. Sánchez-García S, Cipriani F, Ricci G. Food Allergy in childhood: phenotypes, prevention and treatment. Pediatric Allergy and Immunology: Official Publication of the European Society of Pediatric Allergy and Immunology 2015 Dec;26(8):711-720. DOI: 10.1111/pai.12514.26595763
  13. 13. Dave ND, Xiang L, Rehm KE, Marshall GD Jr. Stress and allergic diseases. Immunol Allergy Clin North Am 2011;31(1):55-68. DOI:10.1016/j.iac.2010.09.009326404821094923
  14. 14. Barnthouse M, Jones BL. The Impact of Environmental Chronic and Toxic Stress on Asthma. Clin Rev Allergy Immunol. 2019;57(3):427-438. doi:10.1007/s12016-019-08736-x31079340
  15. 15. Theoharides TC, Enakuaa S, Sismanopoulos N, et al. Contribution of stress to asthma worsening through mast cell activation. Ann Allergy Asthma Immunol. 2012;109(1):14-19. doi:10.1016/j.anai.2012.03.00322727152
  16. 16. Priftis KN, Papadimitriou A, Nicolaidou P, Chrousos GP. Dysregulation of the stress response in asthmatic children. Allergy. 2009;64(1):18-31. doi:10.1111/j.1398-9995.2008.01948.
  17. 17. Dreger LC, Kozyrskyj AL, HayGlass KT, Becker AB, Mac-Neil BJ. Lower cortisol levels in children with asthma exposed to recurrent maternal distress from birth. J Allergy Clin Immunol. 2010;125(1):116-122. doi:10.1016/j. jaci.2009.09.051
  18. 18. Haczku A, Panettieri RA Jr. Social stress and asthma: the role of corticosteroid insensitivity. J Allergy Clin Immunol. 2010;125(3):550-558. doi:10.1016/j.jaci.2009.11.005283905920153032
  19. 19. WHO and United Nations Definition of Adolescent. https://www.publichealth.com.ng/who-and-united-nations-definition-of-adolescent/#:~:text=The%20World%20Health%20Organization%20%28WHO%29%20and%20the%20United,the%20Convention%20on%20the%20Rights%20of%20the%20Child. (accessed on 24th June 2022)
  20. 20. Fidalgo S, Ivanov DK, Wood SH. Serotonin: from top to bottom. Biogerontology 2013;14(1):21-45. DOI:10.1007/s10522-012-9406-323100172
  21. 21. Kim TH, An SH, Cha JY, et al. Association of 5-hydroxytryptamine (serotonin) receptor 4 (5-HTR4) gene polymorphisms with asthma. Respirology (Carlton, Vic.) 2011 May;16(4):630-638. DOI: 10.1111/j.1440-1843.2011.01963.x.21382128
  22. 22. Shajib MS, Khan WI. The role of serotonin and its receptors in activation of immune responses and inflammation. Acta Physiol (Oxf) 2015;213(3):561-574. DOI:10.1111/apha.12430
  23. 23. Farjadian S, Moghtaderi M, Fakhraei B, Nasiri M, Farjam M. Association between serotonin transporter gene polymorphisms and childhood asthma. J Asthma 2013;50(10):1031-1035. DOI:10.3109/02770903.2013.834 503
  24. 24. Heine RG. Preventing atopy and allergic disease. Nestle Nutr Inst Workshop Ser 2014;78:141-153. DOI:10.1159/000354954
  25. 25. Schatz M, Rosenwasser L. The allergic asthma pheno-type. J Allergy Clin Immunol Pract 2014;2(6):645-649. DOI:10.1016/j.jaip.2014.09.004
  26. 26. Fuchs O, Bahmer T, Rabe KF, von Mutius E. Asthma transition from childhood into adulthood. Lancet Respir Med 2017;5(3):224-234. DOI:10.1016/S2213-2600(16)30187-4
  27. 27. Toskala E, Kennedy DW. Asthma risk factors. Int Forum Allergy Rhinol 2015; 5 Suppl 1(Suppl 1): S11-S16. DOI:10.1002/alr.21557715977326335830
  28. 28. Okada M, Northup JK, Ozaki N, Russell JT, Linnoila M, Goldman D. Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution. Mol Psychiatry. 2004;9(1):55-64. doi:10.1038/sj.mp.400135714699441
  29. 29. Land MA, Chapman HL, Davis-Reyes BD, et al. Serotonin 5-HT2C Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro. Sci Rep. 2019;9(1):16737. Published 2019 Nov 13. doi:10.1038/s41598-019-53124-2685391631723224
  30. 30. Human Gene Mutation Database Professional 2022.1, at the Insitute of Medical Genetics in Cardiff. https://my.qiagendigitalinsights.com/bbp/view/hgmd/pro/mut.php?acc=CM981007. (accessed on 25th June 2022)
  31. 31. Drago A, Serretti A. Focus on HTR2C: A possible suggestion for genetic studies of complex disorders. Am J Med Genet B Neuropsychiatr Genet 2009;150B(5):601-637. DOI:10.1002/ajmg.b.3086418802918
  32. 32. Omari-Asor L, Stewart R, Artero S, Ritchie K. 5-HTTLPR genotype, asthma, diabetes and late-life depression in an older French population. Int J Geriatr Psychiatry 2015;30(10):1017-1022. DOI:10.1002/gps.425525640317
  33. 33. Royo JL. Hardy Weinberg Equilibrium Disturbances in Case-Control Studies Lead to Non-Conclusive Results. Cell J. 2021;22(4):572-574. doi:10.22074/cellj.2021.7195721127332347052
  34. 34. Choudhury A, Hazelhurst S, Meintjes A, et al. Population-specific common SNPs reflect demographic histories and highlight regions of genomic plasticity with functional relevance. BMC Genomics 2014;15(1):437. Published 2014 Jun 6. DOI:10.1186/1471-2164-15-437.409222524906912
Language: English
Page range: 126 - 132
Published on: Jul 18, 2022
Published by: European Biotechnology Thematic Network Association
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2022 Sehime Gulsun Temel, Mahmut Cerkez Ergoren, Izel Yilmaz, Ozel Yuruker, Havva Cobanogullari, Ozgur Tosun, Haluk Barbaros Oral, Nerin Nadir Bahceciler, published by European Biotechnology Thematic Network Association
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.