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New strategies for the control of infectious and parasitic diseases in blood donors: the impact of pathogen inactivation methods Cover

New strategies for the control of infectious and parasitic diseases in blood donors: the impact of pathogen inactivation methods

By: Luca Galli and  Fabrizio Bruschi  
Open Access
|Apr 2020

Figures & Tables

Figure 1

Amotosalen/UVA technology mechanism of action. Photoactive compound targets nucleic acids; UVA illumination activates photoactive compuond causing permanent cross-links between the double-stranded chains and blocks the replication of DNA and RNA. From: http://www.intercept-usa.com.

Figure 2

Mirasol mechanism of action. From Ref. (77), with permission.

Figure 3

Reduction of various bacterial species when treated with Mirasol PRT System. From Ref (77), with permission.

Reduction of infectious disease agent logs induced by different PI technologiesResults are expressed as > number indicate that the pathogen concentrations was reduced to the limit of detection of the assay

PathogenAmotosalen/UVARiboflavin/UVUVCAmustaline-GSH
HBVEnveloped virus>5.5 (66)2.5 (76)na

not available.

>5.1 (105)
HCVEnveloped virus>4.5 (66)3.2 (76)>4.9 (103)na

not available.

HIV (cell free) latentEnveloped virus>6.2 (66)>4.5 (76)1.4 (90)>6.5 (92)
HIV (cell-associated) activeEnveloped virus>6.1 (66)>5.9 (76)na

not available.

>5.9 (91)
CMVEnveloped virus>5.9 (66)2.1 (76)na

not available.

>6 (105)
WNVEnveloped virus>6.0 (66)>5.1 (76)3.4 - 4 (85)> 6.0 (93)
CHIKVEnveloped virus>6.9 (31)2.1 - 4 (83)6.34 (86)> 6.78 (31)
Influenza A virusEnveloped virus>5.9 (66)>5 (76)na

not available.

na

not available.

HAVNonenveloped virus0.6 (98)1.8 (76)4.2 (87)na

not available.

Parvovirus B19Nonenveloped virus3.5-5.0 (99)>5 (76)5.4 (31)na

not available.

Zika VirusEnveloped virus> 6 (68)na

not available.

5.7 (104)5.99 (94)
Dengue VirusEnveloped virus> 4.3 (100)1.8 (101)>4.6 (86)6.61 (106)
Staphylococcus aureusBacteria (Gram positive)>6.6 (67)4.8 (6)>4.4 (88)5.1 (91)
Staphylococus epidermidisBacteria (Gram positive)>6.6 (67)4.2 (102)4.6 (88)> 6.9 (92)
Pseudomonas aeruginosaBacteria (Gram negative)4.5 (67)4.5 (6)4.9 (84)4.5 (92)
Escherichia coliBacteria negative) (Gram>6.4 (67)4.4 (102)7.3 (88)>6.7 (91)
Serratia marcescensBacteria (Gram negative)> 6.7 (67)4 (6)> 5 (88)5.1 (91)
Yersinia enterocoliticaBacteria (Gram negative)> 5.9 (66)3.3 (6)na

not available.

>6.8 (93)
Trypanosoma cruziProtozoa>5.3 (66)>5 (76)na

not available.

> 5.4 (93)
Plasmodium sppProtozoa>6 (66)>3.2 (76)na

not available.

> 6.8 (93)
Babesia sppProtozoa> 5.3 (66)>4 (76)> 5 (89)>5.5 (93)
Language: English
Page range: 53 - 66
Published on: Apr 30, 2020
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2020 Luca Galli, Fabrizio Bruschi, published by European Biotechnology Thematic Network Association
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.