Table 1.
Basic socio-demographic and clinical characteristics of recruited patients
| Varaible | Mean ± standard deviation (range) or number (%) |
|---|---|
| Gender (M/F) | 37 (58.7%) / 26 (41.3%) |
| Age (years) | 63.92±1.62 |
| Body weight (kg) | 78.46±12.73 |
| Charlson comorbidity index | 4.25±2.66 |
| Hypertension | 20 (31.7%) |
| Chronic renal insufficiency | 8 (12.7%) |
| Cerebral infarction | 11 (17.5%) |
Table 2.
The most common causes of infections in our patients
| Bacteria | Number (%) |
|---|---|
| Klebsiella spp. | 17 (27%) |
| Staphylococcus aureus | 12 (19%) |
| Proteus mirabilis | 12 (19%) |
| Acinetobacter spp. | 9 (14.3%) |
| Pseudomonas aeruginosa | 6 (9.5%) |
| Enterobacter | 4 (6.3%) |
| Escherichia coli | 3 (4.8%) |
Table 3.
Crude and adjusted odds ratios (OR) of the risk factors for meropenem underdosing in critically ill patients
| Risk factors | Univariate model Crude OR with 95% CI p | Multivariate model Adjusted OR with 95% CI p |
|---|---|---|
| Gender | 5.037 (1.188–21.359) p=0.028* | 4.505 (0.562–36.087) p=0.156 |
| Age | 1.004 (0.954–1.057) p=0.878 | 0.988 (0.891–1.095) p=0.818 |
| Acinetobacter spp. | 3.778 (1.942–6.725) p=0.000* | 4.637 (1.365–14.961) p=0.000* |
| Pseudomonas aeruginosa | 1.812 (1.147–5.125) p=0.044* | 2.938 (1.392–7.116) p=0.035* |
| Pneumonia | 1.286 (0.329–5.021) p=0.718 | 4.945 (0.393–62.148) p=0.216 |
| Urinary tract infection | 0.600 (0.142–2.532) p=0.487 | 0.676 (0.075–6.088) p=0.727 |