References
- Ofori-Asenso R, Chin KL, Curtis AJ, Zomer E, Zoungas S, Liew D. Recent Patterns of Multimorbidity Among Older Adults in High-Income Countries. Popul Health Manag. 2019;22(2):127–137.
- Radević S, Radovanović S, Đonović N, Simić Vukomanović I, Mihailović N, Janićijević K, et al. Socioeconomic inequalities and non-communicable diseases in Serbia: National health survey. Vojnosanitetski pregled. 2018;75(9):926–34. doi: 10.2298/VSP160329017R
- Lu J, Wang Y, Hou L, Zuo Z, Zhang N, Wei A. Multimorbidity patterns in old adults and their associated multi-layered factors: a cross-sectional study. BMC Geriatr. 2021;21(1):372.
- Sakib MN, Shooshtari S, St John P, Menec V. The prevalence of multimorbidity and associations with lifestyle factors among middle-aged Canadians: an analysis of Canadian Longitudinal Study on Aging data. BMC Public Health. 2019;19(1):243.
- Khan MR, Malik MA, Akhtar SN, et al. Multimorbidity and its associated risk factors among older adults in India. BMC Public Health 2022;22: 746.
- Kim J, Keshavjee S, Atun R. Trends, patterns and health consequences of multimorbidity among South Korea adults: Analysis of nationally representative survey data 2007–2016. J Glob Health. 2020;10(2):020426.
- Ho IS, Azcoaga-Lorenzo A, Akbari A, et al. Variation in the estimated prevalence of multimorbidity: systematic review and meta-analysis of 193 international studies. BMJ Open. 2022;12(4):e057017.
- Asogwa OA, Boateng D, Marza-Florensa A, et al. Multimorbidity of non-communicable diseases in low-income and middle-income countries: a systematic review and metaanalysis. BMJ Open 2022; 12:e049133.
- Hernández B, Reilly RB, Kenny RA. Investigation of multimorbidity and prevalent disease combinations in older Irish adults using network analysis and association rules. Sci Rep. 2019;9(1):14567.
- Reddy MM, Zaman K, Yadav R, et al. Prevalence, Associated Factors, and Health Expenditures of Noncommunicable Disease Multimorbidity-Findings From Gorakhpur Health and Demographic Surveillance System. Front Public Health 2022;10: 842561.
- Pati S, Swain S, Knottnerus JA, et al. Health related quality of life in multimorbidity: a primary-care based study from Odisha, India. Health Qual Life Outcomes 2019; 17: 116.
- Kshatri JS, Palo SK, Bhoi T, Barik SR, Pati S. Prevalence and Patterns of Multimorbidity Among Rural Elderly: Findings of the AHSETS Study. Front Public Health. 2020;8:582663.
- Schiltz NK. Prevalence of multimorbidity combinations and their association with medical costs and poor health: A population-based study of U.S. adults. Front Public Health. 2022;10:953886.
- Basto-Abreu A, Barrientos-Gutierrez T, Wade AN, et al. Multimorbidity matters in low and middle-income countries. J Multimorb Comorb 2022; 12:26335565221106074.
- Gupta P, Patel SA, Sharma H, et al. Burden, patterns, and impact of multimorbidity in North India: findings from a rural population-based study. BMC Public Health 2022; 22: 1101.
- Zhong Y, Qin G, Xi H, Cai D, Wang Y, Wang T, Gao Y. Prevalence, patterns of multimorbidity and associations with health care utilization among middle-aged and older people in China. BMC Public Health. 2023;23(1):537. doi: 10.1186/s12889-023-15412-5.
- Nguyen H, Manolova G, Daskalopoulou C, Vitoratou S, Prince M, Prina AM. Prevalence of multimorbidity in community settings: A systematic review and meta-analysis of observational studies. J Comorb. 2019;9:2235042X19870934. doi: 10.1177/2235042X19870934.
- Oleribe OO, Momoh J, Uzochukwu BS, Mbofana F, Adebiyi A, Barbera T, Williams R, Taylor-Robinson SD. Identifying Key Challenges Facing Healthcare Systems In Africa And Potential Solutions. Int J Gen Med. 2019;12:395–403. doi: 10.2147/IJGM.S223882.
- Sum G, Salisbury C, Koh GC, Atun R, Oldenburg B, McPake B, Vellakkal S, Lee JT. Implications of multimorbidity patterns on health care utilisation and quality of life in middle-income countries: cross-sectional analysis. J Glob Health. 2019;9(2):020413. doi: 10.7189/jogh.09.020413.
- Akugizibwe R, Calderón-Larrañaga A, Roso-Llorach A, et al. Multimorbidity patterns and unplanned hospitalisation in a cohort of older Adults. J Clin Med. 2020;9(12):4001. doi: 10.3390/jcm9124001.
- Canever JB, de Souza MB, Danielewicz AL, et al. Are multimorbidity patterns associated with fear of falling in community-dwelling older adults? BMC Geriatr. 2022;22(1):192. doi: 10.1186/s12877-022-02889-9.
- Hajat C, Stein E. The global burden of multiple chronic conditions: A narrative review. Prev Med Rep. 2018;12:284–293. doi: 10.1016/j.pmedr.2018.10.008.
- Nguyen H, Chua KC, Dregan A, Vitoratou S, Bayes-Marin I, Olaya B, Prina AM. Factors Associated With Multimorbidity Patterns in Older Adults in England: Findings From the English Longitudinal Study of Aging (ELSA). J Aging Health. 2020;32(9):1120–1132. doi: 10.1177/0898264319891026.
- Sakib, M.N., Shooshtari, S., St. John, P. et al. The prevalence of multimorbidity and associations with lifestyle factors among middle-aged Canadians: an analysis of Canadian Longitudinal Study on Aging data. BMC Public Health 2019;19:243.
https://doi.org/10.1186/s12889-019-6567-x - Nguyen H, Manolova G, Daskalopoulou C, Vitoratou S, Prince M, Prina AM. Prevalence of multimorbidity in community settings: A systematic review and meta-analysis of observational studies. J Comorb. 2019;9:2235042X19870934. doi: 10.1177/2235042X19870934.
- Alimohammadian M, Majidi A, Yaseri M, Ahmadi B, Islami F, Derakhshan M, et al. Multimorbidity as an important issue among women: results of a gender difference investigation in a large population-based cross-sectional study in West Asia. BMJ Open. 2017;7(5):e013548. doi: 10.1136/bmjopen-2016-013548.
- Wikström K, Lindström J, Harald K, et al. Clinical and lifestyle-related risk factors for incident multimorbidity: 10-year follow-up of finnish population-based cohorts 1982–2012. Eur J Intern Med 2015;26:211–6. 10.1016/j.ejim.2015.02.012
- Ingram E, et al. Household and area-level social determinants of multimorbidity: a systematic review. J Epidemiol Community Health. 2021;75:232–241. doi: 10.1136/jech-2020-214691
- Kuo RN, Lai MS. The influence of socio-economic status and multimorbidity patterns on healthcare costs: a six-year follow-up under a universal healthcare system. Int J Equity Health 2013;12:69 10.1186/1475-9276-12-69
- Skou ST, Mair FS, Fortin M, Guthrie B, Nunes BP, Miranda JJ, Boyd CM, Pati S, Mtenga S, Smith SM. Multimorbidity. Nat Rev Dis Primers. 2022;8(1):48. doi: 10.1038/s41572-022-00376-4.
- Hudon C, Fortin M, Poitras ME, Almirall J. The relationship between literacy and multimorbidity in a primary care setting. BMC Fam Pract. 2012;13:33. doi: 10.1186/1471-2296-13-33.
- Fortin M, et al. Lifestyle factors and multimorbidity: a cross sectional study. BMC Public Health. 2014;14:686. doi: 10.1186/1471-2458-14-686.
- Skou ST, Mair FS, Fortin M, Guthrie B, Nunes BP, Miranda JJ, Boyd CM, Pati S, Mtenga S, Smith SM. Multimorbidity. Nat Rev Dis Primers. 2022;8(1):48. doi: 10.1038/s41572-022-00376-4.
- He L, et al. The prevalence of multimorbidity and its association with physical activity and sleep duration in middle aged and elderly adults: a longitudinal analysis from China. Int J Behav Nutr Phys Act. 2021;18:77. doi: 10.1186/s12966-021-01150-7.
- Shang X, Peng W, Wu J, He M, Zhang L. Leading determinants for multimorbidity in middle-aged Australian men and women: A nine-year follow-up cohort study. Prev Med. 2020;141:106260. doi: 10.1016/j.ypmed.2020.106260.
- Mishra VK, Srivastava S, T M, Murthy PV. Population attributable risk for multimorbidity among adult women in India: Do smoking tobacco, chewing tobacco and consuming alcohol make a difference? PloS one. 2021;16:e0259578. doi: 10.1371/journal.pone.0259578.
- Loprinzi PD. Sedentary behavior and medical multimorbidity. Physiol Behav. 2015;151:395–397. doi: 10.1016/j.physbeh.2015.08.016
- Hudon C, Soubhi H, Fortin M. Relationship between multimorbidity and physical activity: secondary analysis from the Quebec health survey. BMC Public Health 2008;8:304. doi:10.1186/1471-2458-8-304
- Harrison C, Henderson J, Miller G, Britt H. The prevalence of complex multimorbidity in Australia. Aust N Z J Public Health. 2016;40(3):239–44. doi: 10.1111/1753-6405.12509.
- Fisher K, Griffith LE, Gruneir A, Kanters D, Markle-Reid M, Ploeg J. Functional limitations in people with multimorbidity and the association with mental health conditions: Baseline data from the Canadian Longitudinal Study on Aging (CLSA). PLoS One. 2021;16(8):e0255907. doi: 10.1371/journal.pone.0255907.
- Singh K, Alomari A, Lenjawi B. Prevalence of Multimorbidity in the Middle East: A Systematic Review of Observational Studies. Int J Environ Res Public Health. 2022;19(24):16502. doi: 10.3390/ijerph192416502
- Marija S, Dragan V, Svetlana R, Nela D. Socioeconomic Inequalities in Overweight and Obesity in Serbia: Data from 2013 National Health Survey. Front Pharmacol. 2018;8:967. doi: 10.3389/fphar.2017.00967.
- Gunn JM, Ayton DR, Densley K, Pallant JF, Chondros P, Herrman HE, Dowrick CF. The association between chronic illness, multimorbidity and depressive symptoms in an Australian primary care cohort. Soc Psychiatry Psychiatr Epidemiol. 2012;47(2):175–84. doi: 10.1007/s00127-010-0330-z.
- Mavaddat N, Valderas JM, van der Linde R, Khaw KT, Kinmonth AL. Association of self-rated health with multimorbidity, chronic disease and psychosocial factors in a large middle-aged and older cohort from general practice: a cross-sectional study. BMC Fam Pract. 2014;15:185. doi: 10.1186/s12875-014-0185-6.
- Prior A, et al. Perceived Stress, Multimorbidity, and Risk for Hospitalizations for Ambulatory Care–sensitive Conditions: A Population-based Cohort Study. Medical Care. 2017;55 doi: 10.1097/MLR.0000000000000632.
- Cezard G, McHale C, Sullivan F, Bowles J, Keenan K. Studying trajectories of multimorbidity: a systematic scoping review of longitudinal approaches and evidence. medRxiv. 2021:2020.2011.2016.20232363. doi: 10.1136/bmjopen-2020-048485.
- Bähler C, Huber CA, Brüngger B, Reich O. Multimorbidity, health care utilization and costs in an elderly community-dwelling population: a claims data based observational study. BMC Health Serv Res. 2015;15:23. doi: 10.1186/s12913-015-0698-2.
- Brennan P, Perola M, van Ommen GJ, Riboli E; European Cohort Consortium. Chronic disease research in Europe and the need for integrated population cohorts. Eur J Epidemiol. 2017;32(9):741–749. doi: 10.1007/s10654-017-0315-2.
- Kaluvu L, Asogwa OA, Marzà-Florensa A, Kyobutungi C, Levitt NS, Boateng D, Klipstein-Grobusch K. Multimorbidity of communicable and non-communicable diseases in low- and middle-income countries: A systematic review. J Multimorb Comorb. 2022;12:26335565221112593. doi: 10.1177/26335565221112593.
- van den Bussche H, Schön G, Kolonko T, Hansen H, Wegscheider K, Glaeske G, Koller D. Patterns of ambulatory medical care utilization in elderly patients with special reference to chronic diseases and multimorbidity--results from a claims data based observational study in Germany. BMC Geriatr. 2011;11:54. doi: 10.1186/1471-2318-11-54.
- McLean G, Gunn J, Wyke S, Guthrie B, Watt GC, Blane DN, Mercer SW. The influence of socioeconomic deprivation on multimorbidity at different ages: a cross-sectional study. Br J Gen Pract. 2014;64(624):e440–7. doi: 10.3399/bjgp14X680545.
- Payne RA. The epidemiology of polypharmacy. Clin Med (Lond). 2016;16(5):465–469. doi: 10.7861/clinmedic ine.16-5-465.
- Payne RA. Abel GA. Avery AJ. Mercer SW. Roland MO. Is polypharmacy always hazardous? A retrospective cohort analysis using linked electronic health records from primary and secondary care. Br J Clin Pharmacol. 2014;77:1073–82. doi: 10.1111/bcp.12292
- Aggarwal P, Woolford SJ, Patel HP. Multi-Morbidity and Polypharmacy in Older People: Challenges and Opportunities for Clinical Practice. Geriatrics (Basel). 2020;5(4):85. doi: 10.3390/geriatrics5040085.
- Nicholson K, Salerno J, Borhan S, Cossette B, Guenter D, Vanstone M, et al. The co-occurrence of multimorbidity and polypharmacy among middle-aged and older adults in Canada: A cross-sectional study using the Canadian Longitudinal Study on Aging (CLSA) and the Canadian Primary Care Sentinel Surveillance Network (CPCSSN). PLoS One. 2025;20(1):e0312873. doi: 10.1371/journal.pone.0312873.
- Suls J, Green PA, Boyd CM. Multimorbidity: Implications and directions for health psychology and behavioral medicine. Health Psychol. 2019;38(9):772–782. doi: 10.1037/hea0000762.
- McPhail SM. Multimorbidity in chronic disease: impact on health care resources and costs. Risk Manag Healthc Policy. 2016;9:143–56. doi: 10.2147/RMHP.S97248.
- Dimitrijev I, Radovanovic S, Vesic Z, Colakovic G, Selakovic V, Lackovic A, et al. Demographic and Socioeconomic Predictors of Prehypertension and Hypertension in the Adult Population: Serbian National Health Survey. Medicina (Kaunas). 2024;60(5):824. doi: 10.3390/medicina60050824.
- White F. Primary health care and public health: foundations of universal health systems. Med Princ Pract. 2015;24(2):103–16. doi: 10.1159/000370197.
- Michelson H, Bolund C, Brandberg Y. Multiple chronic health problems are negatively associated with health-related quality of life (HRQoL) irrespective of age. Qual Life Res. 2000;9:1093–1104. doi: 10.1023/a:1016654621784.
- Lawson KD, et al. Double trouble: the impact of multimorbidity and deprivation on preference-weighted health related quality of life a cross sectional analysis of the Scottish Health Survey. Int J Equity Health. 2013;12:1–9. doi: 10.1186/1475-9276-12-67.
- Foster HME, et al. The effect of socioeconomic deprivation on the association between an extended measurement of unhealthy lifestyle factors and health outcomes: a prospective analysis of the UK Biobank cohort. The Lancet Public health. 2018;3:e576–e585. doi: 10.1016/s2468-2667(18)30200-7.
- Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Compr Physiol. 2012;2:1143–1211. doi: 10.1002/cphy.c110025
- Kernick D, Chew-Graham CA, O'Flynn N. Clinical assessment and management of multimorbidity: NICE guideline. Br J Gen Pract. 2017 May;67(658):235–236. doi: 10.3399/bjgp17X690857.
- Warner KE. Tobacco control policies and their impacts. Past, present, and future. Ann Am Thorac Soc. 2014;11:227–230. doi: 10.1513/AnnalsATS.201307-244PS.
- Kontis V, et al. Three public health interventions could save 94 million lives in 25 years: global impact assessment analysis. Circulation. 2019;140:715–725. doi: 10.1161/CIRCULATIONAHA.118.038160.
- Smith SM, Wallace E, O'Dowd T, Fortin M. Interventions for improving outcomes in patients with multimorbidity in primary care and community settings. Cochrane Database Syst Rev. 2021;1:Cd006560. doi: 10.1002/14651858.CD006560.pub4
- Tinetti ME, Bogardus ST, Jr, Agostini JV. Potential pitfalls of disease-specific guidelines for patients with multiple conditions. N Engl J Med. 2004;351:2870–2874. doi: 10.1056/NEJMsb042458
- Hargraves IG, Montori VM. Aligning care with patient values and priorities. JAMA Intern Med. 2019;179:1697–1698. doi: 10.1001/jamainternmed.2019.4230.
- Wei MY, Mukamal KJ. Multimorbidity, Mortality, and Long-Term Physical Functioning in 3 Prospective Cohorts of Community-Dwelling Adults. Am J Epidemiol. 2018;187:103–112. doi: 10.1093/aje/kwx198. Pati S, Hussain MA, Chauhan AS, Mallick D, Nayak S. Patient navigation pathway and barriers to treatment seeking in cancer in India: a qualitative inquiry. Cancer Epidemiol. 2013;37:973–978. doi: 10.1016/j.canep.2013.09.018.
- Foo KM, Sundram M, Legido-Quigley H. Facilitators and barriers of managing patients with multiple chronic conditions in the community: a qualitative study. BMC Public Health. 2020;20:273. doi: 10.1186/s12889-020-8375-8.
- Muth C, et al. Effectiveness of a complex intervention on Prioritising Multimedication in Multimorbidity (PRIMUM) in primary care: results of a pragmatic cluster randomised controlled trial. BMJ Open. 2018;8:e017740. doi: 10.1136/bmjopen-2017-017740.
- Banerjee A, Hurst J, Fottrell E, Miranda JJ. Multimorbidity: Not Just for the West. Glob Heart. 2020;15:45. doi: 10.5334/gh.835.
- Seiglie JA, Nambiar D, Beran D, Miranda JJ. To tackle diabetes, science and health systems must take into account social context. Nat Med. 2021;27:193–195. doi: 10.1038/s41591-021-01231-x.
- Bernabe-Ortiz A, et al. Effect of salt substitution on community-wide blood pressure and hypertension incidence. Nat Med. 2020;26:374–378. doi: 10.1038/s41591-020-0754-2.
- Araya R, et al. Effect of a Digital Intervention on Depressive Symptoms in Patients With Comorbid Hypertension or Diabetes in Brazil and Peru: Two Randomized Clinical Trials. Jama. 2021;325:1852–1862. doi: 10.1001/jama.2021.4348.