Graph 1.
Number of children with ITP according to gender
Graph 2.
Number of children with ITP according to age
Graph 3.
Degree of bleeding according to BSS in children with ITP
Graph 4.
Dominant sites of bleeding in children with ITP
Graph 5.
Frequency of other autoimmune diseases in children with ITP
Table 1.
Frequency of autoimmune diseases in the family in children with ITP
| ndITP | pITP | cITP | ||||
|---|---|---|---|---|---|---|
| Family history | N | % | N | % | N | % |
| ITP in the family | 0 | 0 | 1 | 4.5 | 3 | 10.3 |
| Thyroid gland diseases | 2 | 7.4 | 2 | 9.0 | 4 | 13.8 |
| Skin diseases | 0 | 0 | 1 | 4.5 | 1 | 3,4 |
| Metabolic diseases | 6 | 22.2 | 3 | 13.6 | 5 | 17.3 |
| Negative family history | 10 | 37.0 | 7 | 31.8 | 8 | 27.6 |
| More members with autoimmune diseases | 9 | 33.4 | 8 | 36.6 | 8 | 27.6 |
Table 2.
Values of lactic dehydrogenase and vitamin D in children with ITP
| ndITP | pITP | cITP | ||||
|---|---|---|---|---|---|---|
| Vitamin D (ng/mL) | N | % | N | % | N | % |
| 30–40 | 6 | 22.2 | 4 | 18.2 | 4 | 13.8 |
| 20–30 | 3 | 11.2 | 2 | 9.1 | 4 | 13.8 |
| 10–20 | 12 | 44.4 | 13 | 59.1 | 14 | 48.3 |
| <10 | 6 | 22.2 | 3 | 13.6 | 7 | 24.1 |
| Lactic dehydrogenase (U/L) | N | % | N | % | N | % |
| <450 | 3 | 11.2 | 14 | 63.6 | 12 | 41.4 |
| 450–750 | 13 | 48.1 | 8 | 36.4 | 15 | 51.7 |
| >750 | 11 | 40.7 | 0 | 0 | 2 | 6.9 |
Table 3.
Number of platelets, mean volume of platelets and percentage of megakaryocytes in children with ITP
| ndITP | pITP | cITP | ||||
|---|---|---|---|---|---|---|
| Platelet count (×109/L) | N | % | N | % | N | % |
| >50 | 2 | 7.4 | 10 | 45.4 | 9 | 31.1 |
| 20–50 | 6 | 22.2 | 8 | 36.4 | 13 | 44.8 |
| 10–20 | 9 | 33.3 | 2 | 9.1 | 5 | 17.2 |
| <10 | 10 | 37.1 | 2 | 9.1 | 2 | 6.9 |
| Mean platelet volume (fL) | N | % | N | % | N | % |
| 7–10 | 6 | 22.2 | 8 | 36.4 | 10 | 34.5 |
| 10–12 | 10 | 37.1 | 14 | 63.6 | 15 | 51.7 |
| >12 | 11 | 40.7 | 0 | 0 | 4 | 13.8 |
| Percentage of megakaryocytes | N | % | N | % | N | % |
| Hyper production | 15 | 55.5 | 14 | 63.6 | 16 | 55.2 |
| Normal | 5 | 18.5 | 3 | 13.6 | 7 | 24.1 |
| Decreased | 7 | 26.0 | 5 | 22.8 | 6 | 20.7 |
Graph 6.
Applied therapy in children with ITP
Table 4.
Presentation of parameters from the platelet kinetics test in children with cITP
| Platelet life span (days) | <0.5 | 0.5–1 | 1–1.5 | 1.5–4 | >4 |
| N | 6 | 13 | 5 | 2 | 3 |
| % | 20.7 | 44.7 | 17.2 | 6.9 | 10.3 |
| Production index | <0.5 | 0.5–1 | 1–1.5 | 1.5–2 | >2 |
| N | 5 | 6 | 7 | 6 | 5 |
| % | 17.2 | 20.7 | 24.3 | 20.7 | 17.2 |
| Place (index) of sequestration | Liver + other organs | Mixed (liver + spleen) | Predominantly the spleen | Spleen | |
| N | 3 | 9 | 3 | 14 | |
| % | 10.3 | 31.1 | 10.3 | 48.3 |