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Evidence of Improvements to Arterial Stiffness Among Regular Users of Combustible Cigarettes – Effect of Inhalation of β-Caryophyllene: A Randomized, Double-Blind, Placebo-Controlled Study Cover

Evidence of Improvements to Arterial Stiffness Among Regular Users of Combustible Cigarettes – Effect of Inhalation of β-Caryophyllene: A Randomized, Double-Blind, Placebo-Controlled Study

Contributions to Tobacco & Nicotine Research
Volume 34 (2025): Issue 3 (June 2025)
By: Kazuya Yamada,  Yoshiharu Matahira,  Nagisa Takuwa,  Yuri Yoshioka,  Shin-ichi Matsumura,  Mayo Higashihara,  Nobuhiro Zaima and  Naoki Unno  
Open Access
|Jul 2025

Figures & Tables

Figure 1.

Flowchart of participant recruitment.
Flowchart of participant recruitment.

Figure 2.

Changes in BCP (a) and nicotine (b) blood concentrations in the placebo and BCP groups before and 10, 20, and 40 min after smoking a capsule-containing cigarette. Error bars represent the standard deviation. BCP = β-caryophyllene.
Changes in BCP (a) and nicotine (b) blood concentrations in the placebo and BCP groups before and 10, 20, and 40 min after smoking a capsule-containing cigarette. Error bars represent the standard deviation. BCP = β-caryophyllene.

Figure 3.

Changes in baPWV from day 0. (a) All participants. (b) Stratified analysis of participants with baPWV < 1,400 cm/s on day 0. (c) Stratified analysis of participants with baPWV ≥ 1,400 cm/s on day 0. Error bars represent standard deviations. *P < 0.05, within-group comparison vs. day 0; †P < 0.05: between-group comparison; baPWV: brachial-ankle pulse wave velocity; BCP: β-caryophyllene.
Changes in baPWV from day 0. (a) All participants. (b) Stratified analysis of participants with baPWV < 1,400 cm/s on day 0. (c) Stratified analysis of participants with baPWV ≥ 1,400 cm/s on day 0. Error bars represent standard deviations. *P < 0.05, within-group comparison vs. day 0; †P < 0.05: between-group comparison; baPWV: brachial-ankle pulse wave velocity; BCP: β-caryophyllene.

Figure 4.

Correlations between baPWV on day 0 and the 12-week change in baPWV in the BCP (a) and placebo (b) groups. baPWV: brachial-ankle pulse wave velocity; BCP: β-caryophyllene.
Correlations between baPWV on day 0 and the 12-week change in baPWV in the BCP (a) and placebo (b) groups. baPWV: brachial-ankle pulse wave velocity; BCP: β-caryophyllene.
DOI: https://doi.org/10.2478/cttr-2025-0011 | Journal eISSN: 2719-9509
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Language: English
Page range: 107 - 116
Submitted on: Nov 22, 2024
Accepted on: Apr 28, 2025
Published on: Jul 22, 2025
Published by: Institut für Tabakforschung GmbH
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Smoking/harm reduction,
tobacco-related disease,
β-caryophyllene,
brachial-ankle pulse wave velocity,
cardiovascular disease
Related subjects:
General interest,
Life sciences,
Life sciences, other,
Physics,
Physics, other

© 2025 Kazuya Yamada, Yoshiharu Matahira, Nagisa Takuwa, Yuri Yoshioka, Shin-ichi Matsumura, Mayo Higashihara, Nobuhiro Zaima, Naoki Unno, published by Institut für Tabakforschung GmbH
This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License.

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