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Evaluation of Dissolution Release Profiles of Nicotine and Three Distinct Flavor Markers in Loose Moist Smokeless Tobacco Products Cover

Evaluation of Dissolution Release Profiles of Nicotine and Three Distinct Flavor Markers in Loose Moist Smokeless Tobacco Products

Contributions to Tobacco & Nicotine Research
Volume 33 (2024): Issue 3 (June 2024)
By: Fadi Aldeek,  John H. Miller and  Tim Danielson  
Open Access
|Aug 2024

Figures & Tables

Figure 1.

UPLC-PDA chromatograms of (A) glycyrrhizic acid, (B) nicotine, (C) methyl salicylate, and (D) ethyl salicylate in fraction 1 from products -C, -A, and -B, respectively. The inserts show the chemical structures of nicotine and the three flavor markers.
UPLC-PDA chromatograms of (A) glycyrrhizic acid, (B) nicotine, (C) methyl salicylate, and (D) ethyl salicylate in fraction 1 from products -C, -A, and -B, respectively. The inserts show the chemical structures of nicotine and the three flavor markers.

Figure 2.

(A) Cumulative release and (B) percent of total dissolution release profiles (n = 12) of nicotine collected from products -A,-B, and -C. (Error Bars ± 1 SD).
(A) Cumulative release and (B) percent of total dissolution release profiles (n = 12) of nicotine collected from products -A,-B, and -C. (Error Bars ± 1 SD).

Figure 3.

(A) Cumulative release and (B) percent of total dissolution release profiles (n = 12) of flavor markers collected from product-A, -B, and -C. (Error Bars ± 1 SD).
(A) Cumulative release and (B) percent of total dissolution release profiles (n = 12) of flavor markers collected from product-A, -B, and -C. (Error Bars ± 1 SD).
DOI: https://doi.org/10.2478/cttr-2024-0005 | Journal eISSN: 2719-9509
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Language: English
Page range: 157 - 163
Submitted on: Feb 15, 2024
Accepted on: Apr 24, 2024
Published on: Aug 10, 2024
Published by: Institut für Tabakforschung GmbH
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Smokeless tobacco,
nicotine,
flavors,
dissolution, USP-4,
release profile,
method development,
validation
Related subjects:
General interest,
Life sciences,
Life sciences, other,
Physics,
Physics, other

© 2024 Fadi Aldeek, John H. Miller, Tim Danielson, published by Institut für Tabakforschung GmbH
This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License.

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